Effects of polycystic ovary syndrome on liver, heart, muscle, and pancreatic-related diseases.
[BACKGROUND] PCOS is far more than an ovarian disorder; it is a systemic metabolic crisis affecting 11-13% of women.
APA
Li B, Li Y, et al. (2026). Effects of polycystic ovary syndrome on liver, heart, muscle, and pancreatic-related diseases.. Frontiers in endocrinology, 17, 1776584. https://doi.org/10.3389/fendo.2026.1776584
MLA
Li B, et al.. "Effects of polycystic ovary syndrome on liver, heart, muscle, and pancreatic-related diseases.." Frontiers in endocrinology, vol. 17, 2026, pp. 1776584.
PMID
42039130
Abstract
[BACKGROUND] PCOS is far more than an ovarian disorder; it is a systemic metabolic crisis affecting 11-13% of women. This review maps its extra-ovarian reach into the liver, heart, muscle, and pancreas.
[METHODS] We analyzed how the "pathophysiological quartet"-insulin resistance, hyperandrogenism, inflammation, and oxidative stress-coordinates systemic damage.
[RESULTS] PCOS prevalence skyrockets to 28.3% in women with obesity. Key findings include a 51.61% prevalence of MASLD in obese patients and a 2-4 fold increase in cardiovascular and type 2 diabetes risk. These manifestations are rooted in a shared metabolic "soil," creating a vicious cycle of androgen excess and multi-organ dysfunction, including sarcopenia and β-cell exhaustion.
[CONCLUSION] Fragmented care is insufficient. The systemic nature of PCOS demands a paradigm shift toward integrated, multidisciplinary management, treating the patient as a metabolic whole.
[METHODS] We analyzed how the "pathophysiological quartet"-insulin resistance, hyperandrogenism, inflammation, and oxidative stress-coordinates systemic damage.
[RESULTS] PCOS prevalence skyrockets to 28.3% in women with obesity. Key findings include a 51.61% prevalence of MASLD in obese patients and a 2-4 fold increase in cardiovascular and type 2 diabetes risk. These manifestations are rooted in a shared metabolic "soil," creating a vicious cycle of androgen excess and multi-organ dysfunction, including sarcopenia and β-cell exhaustion.
[CONCLUSION] Fragmented care is insufficient. The systemic nature of PCOS demands a paradigm shift toward integrated, multidisciplinary management, treating the patient as a metabolic whole.
MeSH Terms
Humans; Polycystic Ovary Syndrome; Female; Liver Diseases; Insulin Resistance; Pancreatic Diseases; Muscular Diseases
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