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Analysis of the TCRβ repertoire characteristics when combining radiotherapy and immunotherapy in cancer.
Cancer is a global public health concern. Radiotherapy (RT) and immunotherapy are increasingly used in cancer treatment, but the specific immune mechanisms underlying their effects remain to be elucidated. The present study analyzed publicl…
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Disseminated intravascular coagulation (DIC) associated with immune checkpoint inhibitor therapy: a real-world study of the FDA adverse event reporting system.
While immune checkpoint inhibitor (ICI)-related adverse effects have gained increasing attention, disseminated intravascular coagulation (DIC) remains understudied. This retrospective study analyzed the FAERS database from 2011 to 2025 usin…
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CRISPR-Cas9 knockout screens to identify drug resistance genes in acute myeloid leukemia.
Acute Myeloid Leukemia (AML) is a hematopoietic malignancy characterized by the uncontrolled proliferation of aberrant myeloid blasts within the bone marrow, resulting in disrupted hematopoiesis and severe clinical consequences. Drug resist…
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Identification and experimental validation of biomarkers for acute myeloid leukemia based on single-cell RNA sequencing data.
[BACKGROUND] Acute myeloid leukemia (AML) is a highly diverse malignant tumor at the molecular level with a high mortality rate. However, its underlying mechanisms remain poorly understood, and reliable biomarkers are lacking. [METHODS] AM…
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First-line Polatuzumab vedotin plus R-CHP in primary mediastinal B-cell lymphoma: A real-world study bridging the gap of the POLARIX trial.
[UNLABELLED] Objective primary mediastinal B-cell lymphoma (PMBCL) is a distinct, aggressive lymphoma predominantly affecting young adults. While dose-intensive regimens are often recommended, their associated long-term toxicities and the n…
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METTL14 integrates tumor-derived SAM to drive parabrachial epigenetic rewiring in pancreatic cancer.
Tumor-neural crosstalk drives cancer progression and neurological symptoms, yet how tumors rewire brain circuits remains unclear. Here, we identified upregulated methyltransferase-like 14 (METTL14) in lateral parabrachial nucleus glutamater…
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Spatiotemporally controlled ferritin-targeting PROTAC nanoplatform for visualized manipulation of endogenous "Iron pool" in pancreatic cancer therapy.
Pancreatic cancer is a highly malignant tumor with limited response to current therapies. Ferroptosis, as a novel approach in cancer treatment, holds great promise for addressing tumors resistant to conventional treatments. While the introd…
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Pancreaticoduodenectomy with longitudinal pancreatojejunostomy for chronic pancreatitis with suspicious pancreatic head mass: our initial experience with open, laparoscopic, and robotic approaches.
[INTRODUCTION] This study aims to evaluate the clinical outcomes of pancreaticoduodenectomy combined with longitudinal pancreatojejunostomy (PD-L) for chronic pancreatitis with a suspicious pancreatic head mass. We evaluated these derived s…
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E2F1-Driven WDHD1 Transcription Enhances Cell-Cycle Progression and Promotes Pancreatic Cancer Progression.
has been identified as a crucial oncogene in various tumors, but its role in pancreatic cancer remains unexplored. This study investigated the mechanisms by which WDHD1 contributes to pancreatic cancer progression. Differential analysis of …
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Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies, due to its aggressive invasiveness and resistance to therapy. The dense, stiff extracellular matrix, composed primarily of collagen I and basement membrane compon…
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A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.
Prostate cancer (PCa) is one of the most prevalent malignant tumors among men globally, with limited treatment options, especially in cases that progress to castration-resistant prostate cancer (CRPC). Identifying novel molecular targets an…
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Nanofluidic Photoelectrochemical Biosensors for Ultrasensitive Detection of Prostate Cancer Biomarkers.
Significant advances have been made in nanofluidic biosensors for the highly efficient detection of disease biomarkers in complex biofluids. However, most research efforts have primarily focused on external voltage-driven sensing mechanisms…
- Correction: Fusobacterium nucleatum drives gastric cancer metastasis via Gbp-CypA-NF-κB-mediated CXCL8 crosstalk between tumor cells and mast cells.
- Gut microbiome-metabolome-ionome network spectrum mapping of colorectal cancer.
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Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma.
[PURPOSE] Dysregulated cholesterol metabolism has emerged as a crucial driver of hepatocellular carcinoma (HCC) progression and immunotherapy resistance. This study aimed to delineate the single-cell landscape of cholesterol metabolism in H…
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LncRNA FOXP4-AS1 facilitates colorectal cancer invasion and migration by enhancing USP7 interaction with ZEB1.
[UNLABELLED] Colorectal cancer (CRC) poses a threat to the health of people worldwide. Long noncoding RNAs (lncRNAs) have been reported to play a key role in regulating carcinogenesis, including CRC. In this study, the levels of lncRNA FOXP…
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Role of traditional Chinese medicine in ferroptosis of liver cancer: Focus on signaling pathways.
[BACKGROUND] Primary liver cancer (PLC) is among the most common malignant tumors of the digestive tract, with high incidence and mortality. Hepatocellular carcinoma (HCC) the predominant PLC form has complex pathogenesis. Traditional Chine…
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Loss of PPARα-UGT1 axis exacerbates triclosan-induced steatohepatitis in humanized UDP-glucuronosyltransferase 1 mice.
Triclosan (TCS) is an antimicrobial toxicant found in a wide range of consumer products and has been detected in human tissues at concentrations ranging from 0.001 to 5 ppm. Hepatotoxic chemicals such as TCS can cause steatotic liver diseas…
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Hsa-miR-99a deficiency contributes to MSI-H colorectal cancer progression by activating the mTOR pathway and inducing Th1/Th2 imbalance.
[BACKGROUND] Hsa-miR-99a has been linked to the advancement of several malignancies, including colorectal cancer (CRC). This investigation seeks to elucidate its function and regulatory network in CRC. [METHODS] Differential expression of …
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A novel frameshift variant in (p.Q170Rfs4) associated with suspected Lynch syndrome in a Chinese family.
[OBJECTIVE] This study aimed to characterize the pathogenic variants in three colon cancer families suspected of Lynch syndrome (LS), providing experimental evidence for precision screening and genetic counseling of the disease. [METHODS] …
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Integrated network toxicology and multi-omics analysis reveals Benzo(a)pyrene-driven molecular networks and prognostic biomarkers in colon cancer.
Benzo(a)pyrene (BaP), an environmental carcinogen, contributes to colon cancer pathogenesis through incompletely elucidated mechanisms. This study integrated network toxicology and multi-omics analyses to decipher BaP-associated molecular s…
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Neobavaisoflavone, a functional metabolite derived from valnemulin, ameliorates DSS-induced ulcerative colitis through activation of the AMPK signaling pathway.
Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), is characterized by sustained mucosal inflammation, disrupted epithelial barrier function, microbial dysbiosis, and impaired intestinal homeostasis. If chronic uncontrolle…
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Photon-counting CT versus Energy-integrating Detector CT in Imaging Lung Cancer.
Background Although energy-integrating detector (EID) CT remains the standard in diagnosing and monitoring lung cancer, it has limitations compared with photon-counting CT (PCCT). However, the role of low-dose PCCT in evaluating lung cancer…
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The effect of Wilms tumor 1-associated protein on ferroptosis and immune escape in non-small-cell lung cancer by mediating N6-methyladenosine modification of Twist1.
[OBJECTIVE] Non-small-cell lung cancer (NSCLC) is one of the most frequently occurring and aggressive cancers globally, but its complex molecular mechanisms remain only partially understood. This study investigated the effects of Wilms tumo…
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Based on network pharmacology and experiments to investigate the inhibitory effect of Licoricesaponin G2 on lung cancer tumor growth.
[ETHNOPHARMACOLOGICAL RELEVANCE] Licoricesaponin G2 (LG2) is an active component in Licorice, which is a widely used traditional Chinese herbal medicine with antioxidant, anti-inflammatory, anti-cancer, and antiviral properties. LG2 can inh…
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Iron-Rich Particles Drive Pulmonary Toxicity of Coal Combustion-Derived Fine Particles via Transferrin Receptor-Mediated Ferroptosis.
Coal-derived fine particles (FPs, …
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LCPBert: ProtBERT-based early-stage lung cancer prediction from T cell receptor beta sequences.
Early detection of lung cancer remains challenging due to limitations of current methods. We developed LCPBert, a deep learning framework leveraging peripheral blood T cell receptor beta (TCRβ) repertoires for early detection of lung cancer…
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Pharmacovigilance study and development of a clinical decision flowchart for personalized selection of trastuzumab, T-DXd, and T-DM1 in breast cancer patients.
[PURPOSE] Trastuzumab, the first anti-human epidermal growth factor receptor 2 (HER2)-targeted drug, is limited by adverse drug events (ADEs). The next-generation antibody-drug conjugates trastuzumab deruxtecan (T-DXd) and trastuzumab emtan…
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Targeting the UFL1-AKT cascade suppresses triple-negative breast cancer progression.
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease with limited therapies. While UFL1-mediated UFMylation has been implicated in various diseases, its role in TNBC remains not fully understood. Here, we demonstr…
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Nano-PROTACs for precision medicine: engineering strategies for enhanced targeting and potency.
Proteolysis-targeting chimeras (PROTACs) represent a transformative therapeutic modality that leverages the endogenous ubiquitin-proteasome system (UPS) to achieve targeted protein degradation. These heterobifunctional molecules facilitate …