Impact of contrast-enhanced computed tomography surveillance frequency on survival outcomes in patients with stage I-III colorectal cancer: A propensity score-matched retrospective cohort study.
TL;DR
Reducing CECT frequency does not appear to compromise OS or DFS in this cohort, supporting potential de-escalation in selected patients, pending prospective validation.
OpenAlex 토픽 ·
Colorectal Cancer Surgical Treatments
Radiomics and Machine Learning in Medical Imaging
MRI in cancer diagnosis
Reducing CECT frequency does not appear to compromise OS or DFS in this cohort, supporting potential de-escalation in selected patients, pending prospective validation.
- 95% CI 0.696-1.757
- 추적기간 78.78 months
- 연구 설계 cohort study
APA
Yiwen Zhang, Lizhu Liu, et al. (2026). Impact of contrast-enhanced computed tomography surveillance frequency on survival outcomes in patients with stage I-III colorectal cancer: A propensity score-matched retrospective cohort study.. European journal of radiology, 199, 112804. https://doi.org/10.1016/j.ejrad.2026.112804
MLA
Yiwen Zhang, et al.. "Impact of contrast-enhanced computed tomography surveillance frequency on survival outcomes in patients with stage I-III colorectal cancer: A propensity score-matched retrospective cohort study.." European journal of radiology, vol. 199, 2026, pp. 112804.
PMID
41849866
Abstract
[BACKGROUND AND PURPOSE] To evaluate if reducing contrast-enhanced computed tomography (CECT) frequency via unenhanced CT impacts survival in stage I-III colorectal cancer (CRC).
[MATERIALS AND METHODS] We conducted a retrospective cohort study of consecutive patients with stage I-III CRC who underwent curative resection at Yunnan Cancer Hospital between January 2012 and January 2020. Patients were categorized into high-frequency (>50% of follow-up scans as CECT) and low-frequency (≤50%) groups. Propensity score matching (PSM) was performed in a 1:4 ratio using nearest-neighbor matching with a caliper of 0.05, incorporating variables such as age, sex, tumor stage, surgical approach, adjuvant chemotherapy, tumor location, and preoperative carcinoembryonic antigen (CEA) levels to balance baseline characteristics. Overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan-Meier curves, log-rank tests, and multivariable Cox proportional hazards models, with subgroup analyses.
[RESULTS] Of 2,180 eligible patients, 2,063 were in the high-frequency group and 117 in the low-frequency group. After PSM, 543 patients were matched (432 high-frequency, 111 low-frequency), achieving balance (all standardized mean differences <0.1). With a median follow-up of 78.78 months, OS events occurred in 19.27% of patients and DFS events in 21.1%. No significant differences in OS (hazard ratio [HR] 1.106, 95% CI 0.696-1.757, P = 0.671) or DFS (HR 0.978, 95% CI 0.666-1.438, P = 0.911) were observed between groups. Multivariable analysis confirmed CECT frequency was not associated with outcomes. Subgroup analyses showed no significant interactions.
[CONCLUSION] Reducing CECT frequency does not appear to compromise OS or DFS in this cohort, supporting potential de-escalation in selected patients, pending prospective validation.
[MATERIALS AND METHODS] We conducted a retrospective cohort study of consecutive patients with stage I-III CRC who underwent curative resection at Yunnan Cancer Hospital between January 2012 and January 2020. Patients were categorized into high-frequency (>50% of follow-up scans as CECT) and low-frequency (≤50%) groups. Propensity score matching (PSM) was performed in a 1:4 ratio using nearest-neighbor matching with a caliper of 0.05, incorporating variables such as age, sex, tumor stage, surgical approach, adjuvant chemotherapy, tumor location, and preoperative carcinoembryonic antigen (CEA) levels to balance baseline characteristics. Overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan-Meier curves, log-rank tests, and multivariable Cox proportional hazards models, with subgroup analyses.
[RESULTS] Of 2,180 eligible patients, 2,063 were in the high-frequency group and 117 in the low-frequency group. After PSM, 543 patients were matched (432 high-frequency, 111 low-frequency), achieving balance (all standardized mean differences <0.1). With a median follow-up of 78.78 months, OS events occurred in 19.27% of patients and DFS events in 21.1%. No significant differences in OS (hazard ratio [HR] 1.106, 95% CI 0.696-1.757, P = 0.671) or DFS (HR 0.978, 95% CI 0.666-1.438, P = 0.911) were observed between groups. Multivariable analysis confirmed CECT frequency was not associated with outcomes. Subgroup analyses showed no significant interactions.
[CONCLUSION] Reducing CECT frequency does not appear to compromise OS or DFS in this cohort, supporting potential de-escalation in selected patients, pending prospective validation.
MeSH Terms
Humans; Female; Male; Colorectal Neoplasms; Retrospective Studies; Propensity Score; Contrast Media; Middle Aged; Tomography, X-Ray Computed; Aged; Neoplasm Staging; China; Adult
같은 제1저자의 인용 많은 논문 (5)
- Comment on: "Interpretable machine learning model for predicting early recurrence of pancreatic cancer: integrating intratumoral and peritumoral radiomics with body composition".
- Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in -amplified gastric cancer.
- Corrigendum to "TMEM176A drives anti-apoptotic signaling through TGM2-mediated ERK activation in gastric cancer" [Int. Immunopharmacol. 168 (2026) 115798].
- Dietary restriction genes as modulators of breast cancer risk through metabolic pathways.
- Transcriptomic landscapes underlying response and resistance to HDAC inhibitor chidamide in triple-negative breast cancer.