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29건 · 최신순-
Proof of Concept, Feasibility, and Safety of Local Anticholinesterase Treatment for Neuromodulator-Induced Facial Muscle Paralysis.
[BACKGROUND] As yet, there is no functional focal reverser for the adverse effects of cosmetic botulinum toxin injections. [OBJECTIVE] The authors report the first Phase 1 study in human subjects of local administration of an anticholinest…
- Resistance to cosmetic botulinum toxin A: A 15-patient case series across 12 sites.
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Reduction of masseter muscle prominence after treatment with onabotulinumtoxinA: Primary results from a randomized phase 2 study.
[BACKGROUND] OnabotA is used to treat masseter muscle prominence (MMP). [OBJECTIVE] To assess the safety and efficacy of OnabotA for MMP in a randomized study. [METHODS] This 12-month, multicenter, double-blind, placebo-controlled, phase …
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The History of Neuromodulators in Dermatologic Surgery.
[BACKGROUND] In 1817 and 1820, the German physician Justinus Kerner published a series of cases of lethal food poisoning that would unknowingly have a lasting impact on medical science. His compilation of over 75 cases linked the consumptio…
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Safety and tolerability of onabotulinumtoxinA in the treatment of upper facial lines from global registration studies in 5298 participants: A meta-analysis.
[BACKGROUND] Since its discovery as a facial aesthetic treatment >30 years ago, onabotulinumtoxinA has received worldwide approval for dynamic upper facial line treatment. [OBJECTIVE] Meta-analysis examining the safety of onabotulinumtoxin…
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Neutralizing Antibody Formation with OnabotulinumtoxinA (BOTOX) Treatment from Global Registration Studies across Multiple Indications: A Meta-Analysis.
Though the formation of neutralizing antibodies (NAbs) during treatment with botulinum neurotoxin is rare, their presence may nonetheless affect the biological activity of botulinum toxin and negatively impact clinical response. The goal of…
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PrabotulinumtoxinA for the treatment of glabellar lines in adults, 65 years of age and older: The fourth in a series of post hoc analyses of the phase III clinical study data.
[BACKGROUND] Despite the absence of Phase III clinical trial data to support their use, 3.4% of all neurotoxin treatments performed internationally for esthetic purposes in 2020 were performed in patients 65 years of age and older. [OBJECT…
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Treatment of glabellar lines with Botox (onabotulinumtoxinA): Development, insights, and impact.
OnabotulinumtoxinA is an injectable medication that produces muscle relaxation through local chemical denervation at the neuromuscular junction. Discovery of onabotulinumtoxinA's aesthetic benefits occurred serendipitously in the 1980s at t…
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Treatment of crow's feet lines and forehead lines with Botox (onabotulinumtoxinA): Development, insights, and impact.
Extrinsic and age-related intrinsic factors contribute to the development of facial lines, including lateral canthal lines (called crow's feet lines [CFL]) and horizontal forehead lines (FHL). OnabotulinumtoxinA is a highly effective treatm…
- Commentary on: Management of Severe Botulinum-Induced Eyelid Ptosis With Pretarsal Botulinum Toxin and Oxymetazoline Hydrochloride 0.1.
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Decades of beauty: Achieving aesthetic goals throughout the lifespan.
[BACKGROUND] Several elements, including age, influence judgments of beauty and attractiveness. Aging is affected by intrinsic factors (e.g., genetics, race/ethnicity, anatomical variations) and extrinsic factors (e.g., lifestyle, environme…
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PrabotulinumtoxinA vs OnabotulinumtoxinA for the Treatment of Adult Males With Moderate to Severe Glabellar Lines: Post-hoc Analyses of the Phase III Clinical Study Data.
[BACKGROUND] Despite a growing interest among men in cosmetic procedures such as botulinum toxin, comparator clinical trial data in this population are limited. [OBJECTIVES] The authors sought to compare the efficacy and safety of prabotul…
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Overview of DaxibotulinumtoxinA for Injection: A Novel Formulation of Botulinum Toxin Type A.
Botulinum toxin type A (BoNTA) products are widely used for therapeutic and aesthetic indications, but there is a need for longer-lasting treatments that maintain symptom relief between injections and reduce the frequency of re-treatment. D…
- Commentary on Restoration of Visual Loss With Retrobulbar Hyaluronidase Injection After Hyaluronic Acid Filler.
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Injectable DaxibotulinumtoxinA for the Treatment of Glabellar Lines: A Phase 2, Randomized, Dose-Ranging, Double-Blind, Multicenter Comparison With OnabotulinumtoxinA and Placebo.
[BACKGROUND] Injectable daxibotulinumtoxinA (RT002) is an investigational botulinum toxin Type A in clinical development. It is formulated with a proprietary peptide and offers the potential of a longer acting neurotoxin therapy. [OBJECTIV…
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Comparing Injectable DaxibotulinumtoxinA and OnabotulinumtoxinA in Moderate and Severe Glabellar Lines: Additional Analyses From a Phase 2, Randomized, Dose-Ranging, Double-Blind, Multicenter Study.
[BACKGROUND] Injectable daxibotulinumtoxinA (RT002) is an investigational botulinum toxin Type A. Published Phase 2 data show that, compared with 20U onabotulinumtoxinA, 40U daxibotulinumtoxinA is associated with a significantly greater res…
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Consensus Recommendations for Combined Aesthetic Interventions in the Face Using Botulinum Toxin, Fillers, and Energy-Based Devices.
[BACKGROUND] The aging process is a complex interplay of intrinsic and extrinsic factors across multiple layers of the face. Accordingly, combining aesthetic interventions targeting different manifestations of aging often leads to better re…
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Consensus Recommendations for Combined Aesthetic Interventions Using Botulinum Toxin, Fillers, and Microfocused Ultrasound in the Neck, Décolletage, Hands, and Other Areas of the Body.
[BACKGROUND] The popularity of aesthetic procedures in the face has led to greater disparity between treated areas and those that still show evidence of true age. Although many areas of the body often require multiple treatment procedures f…
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Development and Validation of a Photonumeric Scale for Assessment of Chin Retrusion.
[BACKGROUND] A validated scale is needed for objective and reproducible comparisons of chin appearance before and after chin augmentation in practice and clinical studies. [OBJECTIVE] To describe the development and validation of the 5-poi…
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Complications in the Cosmetic Dermatology Patient: A Review and Our Experience (Part 1).
[BACKGROUND] Over recent decades, the options available to patients for cosmetic rejuvenation have expanded dramatically. The range of options commonly available to patients now includes neuromodulators, fillers, sclerotherapy, chemical pee…
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Complications in the Cosmetic Dermatology Patient: A Review and Our Experience (Part 2).
[BACKGROUND] Over recent decades, the options available to patients for cosmetic rejuvenation have expanded dramatically. The range of options commonly available to patients now includes neuromodulators, fillers, sclerotherapy, chemical pee…
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Clinical Experience With 11,460 mL of a 20-mg/mL, Smooth, Highly Cohesive, Viscous Hyaluronic Acid Filler.
[BACKGROUND] A 3-dimensional approach to facial rejuvenation restores volume lost over time. Hyaluronic acid (HA) filling agents provide long-lasting correction with minimal side effects and a high level of patient satisfaction. The newest …
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Retro or PeriBulbar Injection Techniques to Reverse Visual Loss After Filler Injections.
[BACKGROUND] With the increasing popularity of three dimensional filler treatments, the tip of the injecting needle or cannula is subdermal, often adjacent to the facial vasculature. Inadvertent canalization of these vessels can rarely resu…
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Facial Soft-Tissue Fillers: Assessing the State of the Science conference---Proceedings report.
The American Academy of Dermatology and the American Society of Plastic Surgeons, with the support of other sister societies, conducted the Facial Soft-Tissue Fillers: Assessing the State of the Science conference in December of 2009. The A…
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Facial Soft-Tissue Fillers conference: Assessing the State of the Science.
The American Academy of Dermatology and the American Society of Plastic Surgeons, with the support of other sister societies, conducted the Facial Soft-Tissue Fillers: Assessing the State of the Science conference in December of 2009. The A…
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Volumizing with a 20-mg/mL smooth, highly cohesive, viscous hyaluronic acid filler and its role in facial rejuvenation therapy.
[BACKGROUND] The new 20 mg/mL hyaluronic acid (HA) dermal filler is a smooth, highly cohesive, viscous formulation developed to restore volume in aesthetic facial rejuvenation. OBJECTIVE Evaluate clinical experience with 20 mg/mL HA dermal …
- Botulinum treatment of forehead wrinkles.
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Botulinum toxin A: its expanding role in dermatology and esthetics.
The use of botulinum toxin A in cosmetic dermatology has increased in popularity due to the efficacy and relative safety of the treatment. Botulinum toxin A is one of eight exotoxins produced by Clostridium botulinum, a Gram-positive, spore…
- Aesthetic indications for botulinum toxin injections.