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TP53 Loss Fuels mTORC1 Activation and Autophagy Suppression to Drive Immune-Cold Colorectal Cancer.
[BACKGROUND] Microsatellite-stable colorectal cancer (MSS CRC) is typically resistant to immune checkpoint blockade and remains an "immune-cold" disease. Wild-type p53 is known to restrain mTOR signaling and support autophagy, yet how TP53 …
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Macrophages in the Mammary Gland Stem Cell Niche: A Double-Edged Sword in Tissue Regeneration and Tumor Initiation.
Stem cell populations employ cell-intrinsic and niche-mediated mechanisms to preserve long-term self-renewal and regenerative potential. We propose that tumor-initiating cells (TICs) hijack this developmental circuitry to sustain their grow…
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Can Intraoperative Cricopharyngeus Muscle Characteristics Be Used to Predict Treatment Success in RCPD?
[OBJECTIVES] To investigate intraoperative findings as predictors for favorable outcomes following Botox injection in patients diagnosed with retrograde cricopharyngeus muscle dysfunction (RCPD). [METHODS] A retrospective review was perfor…
- Pyoderma gangrenosum after breast reduction surgery.
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Role of breast cancer screening in the overdiagnosis of thyroid cancer: results from a cross-sectional nationwide survey.
[BACKGROUND] South Korea has the highest incidence of thyroid cancer worldwide, raising questions regarding the possibility of overdiagnosis. Examining the factors affecting thyroid cancer screening is crucial in elucidating the reasons for…
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Identifying Public Perceptions, Attitudes, and Concerns about Breast Implants and Their Complications: A National Survey.
[BACKGROUND] Aesthetic and reconstructive implant-based breast operations are among the most common plastic surgery procedures. This study assessed the baseline knowledge of common breast implant-associated complications, and their influenc…
- Reply: Public Perceptions on Breast Implant-Associated Anaplastic Large Cell Lymphoma.
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Public Perceptions on Breast Implant-Associated Anaplastic Large Cell Lymphoma.
[BACKGROUND] Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has entered the spotlight, as several high-profile media outlets have begun to relay the evolving science to the public. This study aimed to gauge the baseline…