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Targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with immune checkpoint inhibitors (ICIs) has improved survival across multiple cancer types, but the variability in patient response h…

[OBJECTIVES] The aim of this study was to assess the burden of Burkitt lymphoma (BL) at the global, regional, and national levels from 1990-2021 and to project trends over the next 15 years. [METHODS] Data from the 2021 Global Burden of Di…

Diffuse large B-cell Lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma for which current therapeutic strategies remain insufficient, in part owing to heterogeneity in tumor biology and the immune microenvironment. The…

[BACKGROUND] ZMIZ2, an androgen receptor (AR) transcriptional co-regulator, promotes prostate cancer (PCa) cell proliferation by interacting with AR to upregulate genes associated with cell proliferation; however, its specific cooperative m…

The incidence of prostate cancer continues to increase, making it the second most common malignant tumor among men worldwide. Immunotherapy has emerged as a key therapeutic strategy for treating tumors. Numerous studies have established tha…

Metagenomic approaches offer unprecedented opportunities to characterize microbial community structure and function, yet several challenges remain unresolved. Inconsistent genome quality impairs reliability of metagenome-assembled genomes, …

Recent studies have revealed that the long-recognized link between the historically defined group and colorectal cancer is largely driven by . This species, along with two others ( and ), was recently reclassified as distinct from , highli…

Breast cancer is the most common type of cancer among Saudi women. Despite this prominence, the lack of data on the association between intimate partner violence (IPV) and breast cancer among Saudi women has presented significant obstacles …

Timely breast cancer care remains challenging in South Africa, where both health-system and patient-level barriers contribute to delayed diagnosis and treatment. This study explored healthcare providers' experiences and perspectives on brea…

Pancreatic adenocarcinoma (PAAD) is a highly aggressive malignant tumor of the gastrointestinal tract. Goosecoid (GSC), translated from a homeobox gene, is a protein participating in metastasis of assorted tumors. This study explores the ro…

The tumor suppressor p53 protects genomic integrity in part by regulating transposable elements (TEs). Studies of p53-TE interactions rely on synthetic DNA and reporter assays, estimating expression only at the family or subfamily level and…

[AIMS] In the phase 3 KEYNOTE-689 trial (NCT03765918) among patients with resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC), perioperative pembrolizumab (pembrolizumab before surgery, then continued with standard-…

[OBJECTIVE] To determine parents' supportive care needs trajectories over the first 8 months following their children's diagnosis and identify the predictors of these trajectories. [METHODS] Overall, 100/112 Chinese parents of children new…

[BACKGROUND] Despite clinical efficacy and cost-effectiveness, time to reimbursement for chimeric antigen receptor (CAR) T-cell therapies varies greatly across Europe. We examined these differences, and quantified potential patient benefits…

[OBJECTIVES] To examine the nonlinear association between the red cell distribution width to platelet count ratio (RPR) and the prognosis of diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab-based therapies. [METHODS] D…

[OBJECTIVES] The diabetic kidney is susceptible to renal ischemia/reperfusion (I/R) injury, which is associated with enhanced oxidative stress, inflammatory responses, and cell apoptosis. Resveratrol (RSV) plays a crucial role in protecting…

[BACKGROUND] Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total thyroidec…

[OBJECTIVE] To explore the associations among dyadic coping, close relationship, and psychosocial adaption in prostate cancer couples during the first six months after diagnosis. [METHODS] Newly diagnosed prostate cancer patients and their…

[OBJECTIVE] To explore psychological distress and its influencing factors, including hope, rumination, and fear of disease progression, among spouses of patients diagnosed with familial clustering of hepatitis B virus (HBV) -related hepatoc…

[AIM] Inadequate adherence to colorectal cancer screening reduces individual and population level health benefits. Blood-based tests offer a new modality that may help patients overcome barriers, but there are concerns about the impact of p…