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15건-
TMT1A inhibits lung adenocarcinoma progression by suppressing M2 macrophage polarization.
The role of thiol methyltransferase 1A (TMT1A) in lung adenocarcinoma (LUAD) progression and the immune microenvironment remains unclear. Analysis of clinical samples and public databases revealed significantly lower TMT1A expression in tum…
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Protective Effect of Red Yeast Rice on Immune Checkpoint Inhibitors-Related Atherosclerotic Progression Through Inhibiting Macrophage Inflammatory Response and T Lymphocytes Infiltration.
Immune checkpoint inhibitors (ICIs) have prolonged cancer survival but exacerbated atherosclerotic cardiovascular disease (ASCVD). This research aims to interrogate the underlying mechanism of ICIs-related atherosclerotic progression and th…
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U-shaped association of red cell distribution width to platelet count ratio and prognosis in diffuse large B-cell lymphoma treated with rituximab-based therapy.
[OBJECTIVES] To examine the nonlinear association between the red cell distribution width to platelet count ratio (RPR) and the prognosis of diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab-based therapies. [METHODS] D…
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Inhibition of LONP1 in prostate cancer: bibliometrics-guided target screening and AI-driven antibody design.
[BACKGROUND] Prostate cancer remains one of the most common malignant tumors among men worldwide, with its incidence showing a continuous global increase. In recent years, mitochondria-targeted therapeutic strategies have emerged as a promi…
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Cannabidiol suppresses emergency MDSCs generation by disturbing EEF1B2-mediated C/EBP protein synthesis in colorectal adenomas.
[BACKGROUND] Colorectal cancer often develops from adenomas over years, necessitating early intervention. Myeloid-derived suppressor cells (MDSCs) are major immune suppressive cell types in colon cancer development from adenomas through ear…
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CAD manipulates tumor intrinsic DHO/UBE4B/NF-κB pathway and fuels macrophage cross-talk, promoting HCC metastasis.
[BACKGROUND AND AIMS] Portal vein tumor thrombosis (PVTT), an indicator of clinical metastasis, significantly shortens the lifespan of patients with HCC, and no effective treatment has been established. We aimed to illustrate the mechanisms…
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Immunotherapy-driven remodeling of the tumor immune microenvironment: Spatiotemporal heterogeneity and multidimensional dynamics.
Immunotherapy, by activating the patient's immune system to eliminate tumors, has become a revolutionary strategy in cancer treatment. Among immunotherapy, immune checkpoint blockade (ICB) and adoptive cell therapy (ACT) have demonstrated s…
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[Effects of mild hypothermia on neurological function in rats with spinal cord injury based on adenosine monophosphate activated protein kinase/Nod-like receptor protein 3 pathway].
[OBJECTIVE] To investigate the effect of mild hypothermia on neurological function in rats with spinal cord injury (SCI) based on the adenosine monophosphate activated protein kinase (AMPK)/Nod-like receptor protein 3 (NLRP3) pathway. [MET…
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Donor-derived CD7 CAR T cells for pediatric and adult relapsed/refractory T-ALL/LBL: a phase 2 trial.
This phase 2 trial assessed CD7 chimeric antigen receptor (CAR) T cells derived from previous transplant or newly HLA-matched donors for relapsed/refractory T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL). Early termination from de…
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SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer.
It is well known that activation of oncogenic K-ras alone is insufficient to drive tumor development and that additional factors are needed for full malignant transformation, but the metabolic pathways and regulatory mechanisms that facilit…
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Downregulated granzyme M expression: implications for the immune system and prognosis of thyroid cancer.
Thyroid carcinoma (THCA), the most prevalent endocrine system cancer, is rising worldwide. Granzyme family member GZMM causes tumor cell inflammation and programmed cell death. However, the role of GZMM in THCA has not been investigated. Bi…
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Homologous recombination repair gene alteration is strongly associated with more prostate-specific membrane antigen-positive metastases in newly diagnosed hormone-sensitive prostate cancer with ≤5 conventional imaging defined distant metastases.
[BACKGROUND] The differences in imaging between prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) and conventional imaging (CI) significantly impact disease staging, subsequently influencing…
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Long-term survival after treatment of gastric cancer with S-1 plus oxaliplatin regimen and sintilimab: A case report.
[BACKGROUND] Treatment of metastatic gastric cancer (mGC) relies primarily on chemotherapy, which can be effectively combined with immunotherapy. Despite these interventions, overall survival remains suboptimal. [CASE SUMMARY] We report a …
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Unveiling EFNB2 as a Key Player in Sorafenib Resistance: Insights from Bioinformatics Analysis and Functional Validation in Hepatocellular Carcinoma.
Sorafenib resistance has become a big hurdle for treating advanced HCC; thus, identifying novel targets to overcome sorafenib resistance is of great importance. Thanks to the massive progress in the sequencing and data analysis, high-throug…
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SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer.
[BACKGROUND] Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and has been shown to negatively affect tumor immunity and is associated with poor outcomes of immunotherapy in various cancers. While most research in this …