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TNF-α deficiency underlies NK cell dysfunction in colorectal cancer.
Natural killer (NK) cells are central to innate antitumor immunity, yet their function is systemically compromised in colorectal cancer (CRC). We show that CRC patients exhibit early and pronounced alterations in peripheral blood NK cells, …
FULLTEXT: paradigm shift -
Temporal trends in second primary malignancies among long-term survivors of multiple myeloma across treatment eras: a population-based analysis of the SEER database.
[OBJECTIVE] To evaluate temporal trends in second primary malignancy (SPM) risk among long-term multiple myeloma (MM) survivors across treatment eras. [METHODS] This retrospective cohort study utilized the SEER 17 registries database (1975…
FULLTEXT: paradigm shift -
The interplay between autophagy, p16, and senescence in tumor cells: a systematic review.
Autophagy and cellular senescence are fundamental determinants of tumor cell fate. p16 has emerged as a key regulator at the intersection of these processes, yet its mechanistic role in the autophagy - senescence axis remains incompletely d…
FULLTEXT: paradigm shift -
Integrating virtual screening and molecular dynamics simulations to identify emodin as a PYCR1 inhibitor modulating docetaxel sensitivity in prostate cancer.
Docetaxel (DTX) resistance is the main cause of treatment failure in castration-resistant prostate cancer (CRPC). Pyrroline-5-carboxylic acid reductase 1 (PYCR1) is an enzyme involved in proline metabolism. It is highly expressed in various…
FULLTEXT: paradigm shift -
Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma chaperone-mediated autophagy-dependent GPX4 degradation.
[CONTEXT] Ginkgolic acid (GAC), one of the major active constituents of extract, has been reported as a potential anticancer agent. [OBJECTIVE] To investigate the effect of GAC on the viability of human hepatocellular carcinoma (HCC) cell…
FULLTEXT: paradigm shift -
DA-LUNGNET: a multi-stage deep framework with adaptive attention for early detection of subcentimeter pulmonary nodules.
Early and reliable detection of subcentimeter pulmonary nodules remains a major bottleneck in low-dose CT-based lung cancer screening due to high miss rates, vascular-adhesion-induced false positives, and insufficient multi-scale feature fu…
FULLTEXT: paradigm shift -
Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting.
[BACKGROUND] The lung is a uniquely innervated barrier organ with dynamic neuroimmune interactions that critically regulate respiratory homeostasis. Despite the well-characterized gut-brain axis, pulmonary neuroimmune crosstalk remains an u…
FULLTEXT: paradigm shift -
Rabdosin B suppresses proliferation of nonsmall cell lung cancer by regulating the SRC/PI3K/AKT signaling pathway.
[CONTEXT] Rabdosin B (RB), an active compound derived from the Chinese herb (Burm. f.) H. Hara, has demonstrated inhibitory effects on non-small cell lung cancer (NSCLC) cell proliferation in prior studies. However, its precise mechanism o…
FULLTEXT: paradigm shift -
A data-driven cartography of NSCLC vaccine research: Quantifying the paradigm shift toward immuno-oncology combination therapies.
The therapeutic vaccine landscape for non-small cell lung cancer (NSCLC) has evolved substantially over the past three decades, yet systematic analysis of this progression remains limited. We conducted bibliometric analysis of NSCLC vaccine…
FULLTEXT: paradigm shift -
Mapping research trends in esophageal cancer immunotherapy: A decade of thematic evolution and emerging priorities.
Immunotherapy has become a pivotal therapy for various cancers, including esophageal cancer, showing promising potential in improving survival rates and enabling personalized care. However, significant challenges occur in identifying predic…
FULLTEXT: paradigm shift -
LDH isozymes as targets for cancer therapy.
The Warburg effect, a hallmark of cancer, positions lactate dehydrogenase (LDH) as a key therapeutic target. Mammals possess three LDH isozymes (LDH-A, LDH-B, LDH-C) with distinct properties. This review critically re-evaluates the simplist…
FULLTEXT: paradigm shift -
The 15-year bibliometric landscape of glioblastoma vaccines: Emergence of combinatorial immunotherapy.
Despite the persistently poor prognosis of glioblastoma (GBM), research into novel immunotherapies, particularly tumor vaccines, has flourished, evolving into a highly active and interdisciplinary field. Through a bibliometric analysis of 1…
FULLTEXT: paradigm shift -
A functionally differentiated DNA tetrahedron-based cascaded cyclic catalytic amplification assay for detecting miR-21 in prostate cancer.
A novel multi-functional DNA tetrahedron-based target-induced cascaded cyclic catalytic amplification (TICA) assay was developed for the sensitive detection of microRNA-21 (miR-21) in prostate cancer. This strategy ingeniously integrates tw…
FULLTEXT: paradigm shift -
"Dual-lock" activated nanosystem for colorectal cancer: Defect engineering-driven NIR-II PTT-enhanced ferroptosis to trigger antitumor immunity.
Conventional therapies for colorectal cancer (CRC) are often constrained by limited specificity, while the hypoxic, acidic, and immunosuppressive commonly contributes to immunotherapy resistance. Herein, a dual-responsive nanosystem with ox…
FULLTEXT: paradigm shift -
Chronic inflammation-responsive hydrogel restores myeloid-T cell crosstalk to reinvigorate antitumor immunity against metastatic colorectal cancer.
Chronic inflammation in intermediate/advanced tumors drives burdensome protumor immune cell communication, thereby weakening immunotherapy. Conventional anti-inflammatory therapies focus on alleviating chronic inflammation whereas ignore dy…
FULLTEXT: paradigm shift -
A self-assembled fluorescent contrast agent for imaging-guided simultaneous resection of breast tumors and metastatic lymph nodes in surgery.
Accurate intraoperative margin assessment and reliable detection of metastatic sentinel lymph nodes (SLNs) remain critical challenges in breast cancer surgery. We developed sa-FCA, a novel XIAP-targeting near-infrared fluorescent probe that…
FULLTEXT: paradigm shift -
Strategic modification of outer branched side chains in multi-modal phototheranostic nanoplatform for synergistic breast cancer therapy.
Multi-modal imaging guided photothermal therapy (PTT) combined with photodynamic therapy (PDT) has shown significant advantages in breast cancer treatment. However, the development of superior phototheranostic nanoagents remains highly chal…
FULLTEXT: paradigm shift -
From natural templates to precision tools: Alkaloid-derived probes in elucidating signaling and disease biology.
Alkaloids are a class of plant secondary metabolites with diverse structures and broad biological activities, serving as a crucial source for drug discovery. Currently, the research paradigm in this field is shifting from traditional struct…
FULLTEXT: paradigm shift -
Plasma-based near-infrared spectroscopy combined with aquaphotomics for colorectal cancer screening.
Fast, noninvasive and cost-effective methods for screening colorectal cancer (CRC) before uncomfortable colonoscopy are highly desirable. This study aimed to explore the feasibility of using near-infrared spectroscopy (NIRS) combined with a…
FULLTEXT: paradigm shift -
Dual metabolic reprogramming by metal-polyphenol nanoplatform enhances ferroptotic therapy for triple-negative breast cancer.
While ferroptotic therapy has emerged as a promising strategy for triple-negative breast cancer (TNBC), cellular ferroptosis resistance poses a significant challenge. Given the compensatory up-regulation of dihydroorotate dehydrogenase (DHO…
FULLTEXT: paradigm shift