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TL;DRFindings reveal differential sensitivity to paracetamol during distinct developmental windows, with prenatal exposure leading to long-lasting disruptions in emotional regulation and neuroendocrine stress responses, and p…

TL;DRThe study found that the risk of brain metastasis and disease recurrence increased significantly in the HR(-) HER2-low group, and contrary to some literature data, the risk of brain metastasis in the HR(+) HER2-low group…

Liver disease encompasses a wide range of conditions, each requiring tailored therapeutic approaches. This review describes and critically discusses treatments with robust evidence for improving liver health. Ursodeoxycholic acid (UDCA) is …

[OBJECTIVES] Postoperative pain following breast surgery remains a significant clinical challenge and may delay recovery while increasing the need for systemic analgesics. Dexmedetomidine, a selective α-2 adrenergic receptor agonist, has be…

Nilotinib (NH), a second-generation tyrosine kinase inhibitor for chronic myelogenous leukemia (CML), exhibits poor aqueous solubility and low intestinal permeability, classifying it as a Biopharmaceutics Classification System (BCS) Class I…

Chrysin, a flavone nutraceutical, possesses several beneficial pharmacological properties, which has gained much emphasis in recent years. The biological effects of chrysin are exerted due to impeding or activating multifarious cellular and…

Acetaminophen (paracetamol) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its potential impact on hormonal balance and the risk of hormone-dependent cancers remains unclear. This study aimed to integrate epid…

TL;DRClinicians should exercise caution when prescribing metamizole, limiting its use to well-justified indications and short durations, and maintain clinical vigilance and performing early haematological monitoring, particul…

TL;DRThe derivative was able to reverse the altered expression of several inflammatory biomarkers, including ras-related C3 botulinum toxin substrate 1 (Rac1), cytochrome c oxidase subunit 2 (COX2), phospholipid phosphatase-r…

[BACKGROUND] Effective pain management is crucial in septorhinoplasty and remains a significant challenge. This study investigated the effect of ketorolac and paracetamol on pain control in septorhinoplasty patients and assessed their effic…

TL;DRThis study compares two pain management protocols in patients undergoing abdominal-based free flap breast reconstruction: a past protocol (PP) and a current protocol (CP)—both intended to reduce opioid consumption postop…

TL;DRMidazolam alone as premedication effectively reduced anxiety before, during, and after surgery and Paracetamol with codeine phosphate hemihydrate effectively reduced surgical pain and postoperative pain duration and decr…

 Septorhinoplasty operates on the nose's bone and cartilage and is ensued by severe postoperative pain.  The objective of this study is to evaluate the effects of preoperative administration of intravenous (IV) paracetamol and ibuprofen on…

[OBJECTIVE] Postoperative shivering (POS) is considered one of the most common complications that is encountered by the anaesthetists worldwide. Despite using several treatment options, there has not been a clear consensus regarding this is…

[BACKGROUND] Haemorrhoidectomy is associated with moderate-to-severe postoperative pain. [OBJECTIVE] The aim of this systematic review was to assess the available literature and update previous PROSPECT (procedure specific postoperative pa…

[BACKGROUND] Postoperative healing after clitoral reconstruction (CR) for female genital mutilation/cutting can be long and painful due to prolonged clitoral re-epithelialization time (up to 3 months). Autologous platelet-rich plasma (A-PRP…

[OBJECTIVE] We aimed to compare the effect of dexmedetomidine with remifentanil on hemodynamic stability, surgical field quality, and surgeon satisfaction during rhinoplasty. [METHODS AND MATERIALS] In this double-blind randomized controll…

Strabismus correction surgery is the most common eye operation in children. Adults have approximately a 4% lifetime risk of developing strabismus. Current treatment options include pharmacological injection of botulinum toxin or bupivacaine…

[INTRODUCTION] Nummular headache was initially described as an infrequent primary headache characterised by chronic circumscribed mild-to-moderate pain in a small area of the head that may present with exacerbations. Since its initial descr…

[BACKGROUND AND AIMS] The quadratus lumborum block (QLB) provides regional analgesia of the anterior abdominal wall, theoretically matching the postoperative pain after postbariatric standard full abdominoplasty. We investigated the effecti…