논문 검색

Combining radiotherapy with immune checkpoint inhibitors (RT-ICI) triggers systemic antitumor responses, such as abscopal effects (AbE). Predictors of AbE and its impact on survival in real-world settings remain poorly defined. This multice…

[BACKGROUND] Early-stage diffuse large B-cell lymphoma (ESDLBCL) in older adults is understudied, and existing prognostic tools such as the stage-adjusted International Prognostic Index (Sa-IPI) may not adequately account for comorbidity an…

[BACKGROUND] Prostate cancer (PC) is a common malignancy in older adults. We aimed to construct a nomogram for the overall survival (OS) of elderly patients with locally advanced PC who received radiotherapy and surgery. [METHODS] Clinical…

[OBJECTIVE] To construct and interpret a machine learning model for predicting overall survival in nonsurgical prostate cancer with bone metastases (PCBM). [METHODS] Data from 3,378 SEER database patients were utilized to develop machine l…

[BACKGROUND] Contemporary, systematic comparisons of prostate cancer (PCa) across the entire age spectrum regarding incidence, pathology, treatment, and long-term outcomes remain lacking. [METHODS] Patients were identified from the Surveil…

[BACKGROUND] Surgical resection is the primary treatment for non-small cell lung cancer (NSCLC) patients with stages I and II; however, the postoperative prognosis varies among individuals. The prognostic nutritional index (PNI) reflects th…

[OBJECTIVE] This study investigates serum metabolic profiles in breast cancer to identify diagnostic biomarkers and stage-specific metabolites, offering insights for clinical practice. [METHODS] Gas chromatography‒mass spectrometry (GC‒MS)…

Peritoneal metastasis (PM), as a terminal stage of malignant tumors with extremely poor prognosis, remains a clinical challenge. Intraperitoneal (IP) administration enhances local drug concentrations, improving survival outcomes for PM pati…

[BACKGROUND] Immunotherapy offers potential benefits for recurrent or metastatic cervical cancer (R/M CC), yet personalized predictive tools are essential for optimizing treatment. This study aims to develop a nomogram integrating nutrition…

[BACKGROUND AND PURPOSE] The benefit of adding anti-PD-1 antibodies to definitive chemoradiotherapy (dCRT) in elderly patients with esophageal squamous cell carcinoma (ESCC) remains uncertain. This study evaluated its efficacy and safety ve…

The inhibitory receptor leukocyte immunoglobulin-like receptor B2 (LILRB2), expressed on myeloid cells like monocytes and tumor-resident myeloid cells, sustains an immunosuppressive tumor microenvironment and promotes tumor progression. Pha…

[OBJECTIVE] To determine parents' supportive care needs trajectories over the first 8 months following their children's diagnosis and identify the predictors of these trajectories. [METHODS] Overall, 100/112 Chinese parents of children new…

[BACKGROUND] Histologic transformation from Waldenström macroglobulinemia (WM) to diffuse large B-cell lymphoma (DLBCL) is a rare but clinically challenging event. [METHODS] In this retrospective study, we analyzed 15 cases of histologic t…

[OBJECTIVE] Pancreatic ductal adenocarcinoma (PDAC), a clinically aggressive stage IV cancer, exhibits poor prognosis and limited therapeutic efficacy due to numerous somatic mutations. In this study, we aimed to elucidate the molecular mec…

[BACKGROUND] The advantages of postoperative adjuvant chemotherapy (ACT) for gastric cancer patients with pT1N + M0 staging have been a subject of debate. This study aims to assess whether ACT can enhance the overall survival (OS) of postop…

This study investigated the role of COPB2 in gastric cancer (GC) pathogenesis. Analysis of TCGA datasets and tissue microarrays revealed its upregulation in GC tissues compared to normal adjacent tissues, which was correlated with advanced …

[BACKGROUND] The role of albumin-to-alkaline phosphatase ratio (AAPR) in predicting complications in elderly gastric cancer (GC) patients is unclear. [METHODS] This retrospective study included 358 elderly GC patients (≥60 years of age) wh…

[BACKGROUND] Antiviral therapies for hepatitis B or C virus may be associated with reduced risk of tumor recurrence and mortality of patients with hepatocellular carcinoma (HCC) undergoing curative treatments, compared to untreated patients…

[AIMS] Early detection of hepatocellular carcinoma (HCC) in patients with compensated cirrhosis (CC) is critical for improving prognosis. The GAAD algorithm (gender [biological sex], age, alpha-fetoprotein [AFP], protein induced by vitamin …

[BACKGROUND] Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved endoplasmic reticulum (ER)-resident and secreted protein highly expressed in the digestive system. Emerging evidence has highlighted its …