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[OBJECTIVE] To investigate the thematic focus of patient-led breast cancer key opinion leaders (PBKOLs) on Xiaohongshu by analyzing their postings and identifying underlying narrative patterns. [METHODS] PBKOL accounts were identified thro…

[BACKGROUND] The increasing use of chest imaging has led to a higher detection rate of incidental solitary pulmonary nodules (SPNs), often causing patient anxiety. Determining the malignancy rate and associated risk factors is crucial for d…

[BACKGROUND AND OBJECTIVE] Acute Leukemia (AL) diagnosed during pregnancy is uncommon, and the management of AL complicated by pregnancy is a poorly studied area that faces a therapeutic dilemma. [METHOD] 23 cases diagnosed with AL during …

[BACKGROUND] Menopausal hormone therapy (MHT) is widely prescribed for alleviating menopausal symptoms. Prior studies have mainly focused on individual hormone therapy formulations. This meta-analysis comprehensively synthesized evidence ac…

[BACKGROUND] Robotic and laparoscopic approaches are widely used for rectal cancer surgery. Although robotic systems provide enhanced visualization and dexterity, it remains unclear whether these advantages improve postoperative urinary and…

TL;DRAmitriptyline 100 mg and BTX-A 100 U may be options to reduce monthly headache days in patients with chronic TTH given the low to very low certainty of evidence, high risk of bias, and high heterogeneity.

Accurate subtyping of lung cancer is essential for improving patient prognosis and enabling personalized treatment. However, current clinical techniques are often time-consuming and heavily dependent on the operator's subjective judgment an…

[BACKGROUND] A consistent correlation has been highlighted between screening-based mental health indicators and women suffering from breast cancer (BC), which significantly reduced their related quality of life perceptions. This systematic …

[INTRODUCTION] Stereotactic Body Radiation Therapy (SBRT) offers a curative treatment option for patients with early-stage central and ultra-central lung tumours, however can be associated with severe side effects. This review provides a st…

[BACKGROUND] Globally, the incidence of breast cancer continues to rise; however, mortality rates are declining due to the growing effectiveness of targeted therapies and treatments. Overexpression of human epidermal growth factor receptor …

TL;DRThis in silico study proposes a robust diagnostic gene signature for HCC and identifies tolrestat as a promising repurposing candidate that warrants experimental validation, demonstrating the utility of integrating machi…

[INTRODUCTION] Patient navigation is an evidence-based intervention that can be used to address patient-level barriers and ultimately increase colorectal cancer screening rates. Because implementation can affect the effectiveness of navigat…

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, largely due to the development of distant metastases, which is associated with poor survival outcomes. Early detection and accurate prediction of colorectal c…

[OBJECTIVE] To compare AI-augmented and conventional double reading in organised breast-cancer screening with respect to cancer-detection rate (CDR), recall rate, and radiologist workload. [METHODS] We conducted a systematic review and ran…

[BACKGROUND] Micro-ultrasound (micro-US; 29-MHz) offers real-time, high-resolution prostate imaging, but its stand-alone diagnostic accuracy remains uncertain. We synthesized prospective evidence to evaluate micro-US for classifying clinica…

In the recent decade, immunotherapy has improved lung cancer treatment. However, mono-immunotherapy has substantial clinical limitations, such as low objective response rates, leading to the requirement of combinatorial regimens. Radiation …

TL;DRAlthough the hazard ratio for developing abdominal cancer after EVAR appeared modestly increased in individual cohort analyses, the absolute incidence of abdominal cancer remained low in both treatment groups.

[BACKGROUND] Breast cancer is the most common cancer among women in India, and a substantial proportion present with metastatic disease, which worsens prognosis. Evidence on socio-demographic, clinical, and health system determinants of met…

TL;DRCEM demonstrates high sensitivity and excellent overall accuracy in the evaluation of mammographic asymmetries, making it a valuable tool for ruling out malignancy.

Childhood cancer outcomes in low- and middle-income countries (LMICs), where over 80% of the world's children reside, remain drastically lower than in high-income countries (HICs). This vast disparity stems from pervasive challenges, includ…