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Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, are directly involved in the degradation of the extracellular matrix preceding uncontrolled cancer growth and metastasis. For these reasons, MMPs are considered key therapeutic…

TL;DRA review summarizes the findings related to the role of H19 in liver development and in diseases such as fatty liver, fibrosis, and hepatocellular carcinoma.

[OBJECTIVES] This study evaluated pre-post changes in readiness to engage in cancer screening among populations with low screening rates after using mobile problem-solving tools. Disseminating strategies for tool scale-up were examined. [M…

TL;DRThe potential relationship between P2X2/3 receptors and cancer pain and its potential pharmacological target for the treatment of cancer pain are discussed.

Cancer continues to be a major worldwide health problem, necessitating the continuous discovery of novel therapeutics. The current study investigated the anti-cancer potential of Jacobaea maritima (JM) and Tradescantia pallida (TP) extracts…

TL;DRTot3 CAR-T cells demonstrated significantly enhanced antitumor activity and increased survival times in a mouse model of diffuse B cell lymphoma, and exhibited greater packaging efficiency and reduced thermal stability.

TL;DRThe proposed Hierarchical Dual-Branch Coordinate Attention Network serves as a high-precision foundation for an efficient, reliable, and interpretable auxiliary tool, offering robust support for automated gastric cancer …

Gastric cancer (GC) is the fifth most common type worldwide, representing a public health problem. Among the genes related to this tumorigenesis, the family of matrix metalloproteinases (MMPs), essential regulators of the extracellular matr…

TL;DRThis review outlines the key imaging pitfalls created by diffuse liver disease and offers practical, evidence-based strategies to overcome them, including the atypical appearance of focal lesions on ultrasound and CT due…

[BACKGROUND] Radiology is integral to the multimodal diagnostic and treatment pathway of extremity soft tissue sarcomas in DGK-certified sarcoma centers (DGK: Deutsche Krebsgesellschaft, German Cancer Society), working in close interdiscipl…

Whole Slide Images (WSIs) have been widely used in computational pathology (CPath) for various tasks. However, obtaining high-quality annotations remains a major bottleneck. Task-aware unsupervised anomaly detection models offer a promising…

Currently, the live treatment strategy based on Nissle 1917 (ECN) is widely researched in the field of tumor therapy based on its outstanding tumor targeting and colonization ability. ECN can serve as an immunological adjuvant, releasing s…

Hans' algorithm (HA) is the most frequently used surrogate biomarker scheme for subtyping Diffuse large B-cell lymphoma (DLBCL) by the cell-of-origin (COO) into GCB and non-GCB subtypes. The originally published positive and negative predic…

Brain metastases remain a major problem for cancer patients, impacting their treatment and survival. The pathogenesis of brain metastases is largely unknown. Recent reports indicate that the adhesion molecule protocadherin γ C3 (PCDHGC3) is…

Classical hematoxylin and eosin (H&E) staining enables review of tissue morphology but lacks information regarding the molecular state of cells. Immunohistochemical (IHC) techniques label specific proteins in tissue, allowing differentiatio…

Some aggressive cancers exhibit a level of rapid genome change and therapy resistance that is difficult to explain. Research over the past decade has shown that extrachromosomal DNA (ecDNA) can be the cause. When oncogenic genetic elements …

Canine mammary carcinoma (CMC) is the most frequently diagnosed tumour in unspayed canines and leads to one of the main causes of their deaths, thereby making it a major problem for veterinary medicine. Such neoplasia appears spontaneously …

Ambient air pollution is a global problem linked to various diseases, including neurodegenerative disorders. Using a mobile exposure system, we investigated the molecular changes in human olfactory cleft mucosal (hOM) cells from healthy ind…

Colorectal cancer is one of the deadliest cancers in the world. The main problem with cancer treatments is that they need to protect healthy cells. Cyclin-dependent kinases (CDKs), especially CDK-2 and CDK-1, are essential for regulating th…

TL;DRThe group developed an anti-TfR1 IgG3-avidin fusion protein, ch128.1Av, designed to deliver biotinylated therapeutic agents into cancer cells through receptor-mediated endocytosis, which demonstrated antitumor efficacy i…