논문 검색
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Statement of Retraction: Didox (A Novel Ribonucleotide Reductase Inhibitor) Overcomes bc.l-2 Mediated Radiation Resistance in Prostate Cancer Cell Line PC-3.
FULLTEXT: Position statement
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Financial hardship among patients with lung cancer and their family caregivers: A comparative study of two institution-based samples from Hong Kong and Mainland China.
[OBJECTIVE] To investigate and compare the severity and prevalence of financial hardship among lung cancer patients and their caregivers in two institution-based samples from Hong Kong and Mainland China, emphasizing regional differences in…
FULLTEXT: Position statement -
Global prevalence of anxiety, depression and stress in women with breast cancer: A systematic review and meta-analysis.
[BACKGROUND] A consistent correlation has been highlighted between screening-based mental health indicators and women suffering from breast cancer (BC), which significantly reduced their related quality of life perceptions. This systematic …
FULLTEXT: Position statement -
Green diastereoselective synthesis of spiropyrrolidines by the one-pot three component reaction of isatins, THβC and 5-arylidene-thiazolidine-2,4-diones and its anticancer evaluation.
An efficient, diastereoselective synthesis of spiropyrrolidines by the three component reaction between isatin, 1,2,3,4-tetrahydro-β-carboline and 5-arylidene thiazolidine-2,4-dione by green protocol is reported here. The reaction resulted …
FULLTEXT: Position statement -
ω-Lipid chain-engineered tunicamycin analogues as safer antiproliferative and antimetastatic biochemicals.
Tunicamycins have long served as important biochemical tools to interrogate unfolded protein responses (UPRs) in the endoplasmic reticulum by targeting DPAGT1 (dolichyl-phosphate N-acetylglucosamine-phosphotransferase 1), the first committe…
FULLTEXT: Position statement -
Blocking CEMIP2-mediated low-molecular-weight hyaluronic acid -TGFβ signaling inhibits chemotherapy-associated lymphatic metastasis in gastric cancer.
Chemotherapy-associated metastasis is a major cause of failure of cancer treatment, especially neoadjuvant chemotherapy. Extracellular matrix (ECM) remodeling aways accompany with chemotherapy, but its role in chemotherapy-associated metast…
FULLTEXT: Position statement -
Discovery of C-9 boronated berberine derivatives with enhanced selectivity against breast cancer.
A series of eighteen berberine derivatives were designed and synthesized via molecular hybridization, introducing boronic acid/ester pharmacophores at the C-9 position to improve the selectivity of the natural product against breast cancer.…
FULLTEXT: Position statement -
Hecogenin derivative as an anti-breast cancer agent: Mechanistic insights from multi-computational analysis.
Breast carcinoma poses a significant worldwide health challenge, recording more than 2.3 million incident cases and 665,684 fatalities in 2022, with projections indicating a 38% rise in diagnoses and 68% increase in deaths by 2050, reaching…
FULLTEXT: Position statement -
Engineering ECM-mimetic scaffolds from biological macromolecules for physiologically relevant tumoroid models.
The tumor extracellular matrix (ECM) is a dynamic, tissue-specific network of structural proteins, adhesive glycoproteins, and glycosaminoglycans that governs cancer cell behaviour, mechanotransduction, invasion, and therapeutic response. W…
FULLTEXT: Position statement -
Synthesis and cytotoxic evaluation of pyrido-dipyrimidine derivatives: Mechanism of action, DNA and HSA binding studies.
This study presents the synthesis of a novel series of pyrido[2,3-d:6,5-d']dipyrimidine derivatives (4a-v) via an 'on-water' multicomponent reaction, utilizing thiobarbituric acid, diverse aldehydes, and amines at room temperature. The comp…
FULLTEXT: Position statement -
Gossypol suppresses tumorigenesis through inhibition of multiple deubiquitinating enzymes.
Gossypol is a polyphenolic compound recognized for its role as a Bcl-2 family protein inhibitor, attracting considerable interest mainly due to its antitumor properties. However, its development as a therapeutic agent has faced hurdles from…
FULLTEXT: Position statement -
Novel 2-Anilinoquinazoline derivatives as apoptosis-inducing agents in drug-resistant NSCLC cells: Integrating biological and computational evaluation.
Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small-cell lung cancer (NSCLC) accounting for approximately 85% of all cases. Despite widespread use, the limited durability of epidermal growth factor re…
FULLTEXT: Position statement -
Structural characterization and antitumor activity via immune modulation of an α-glucan from Grifola frondosa.
Grifola frondosa is a valued edible and medicinal fungus whose polysaccharides are key bioactive components, yet the identification of specific homogeneous effectors and their detailed immunomodulatory mechanisms remains a critical focus of…
FULLTEXT: Position statement -
Targeting SETD2 in Cancer therapy: Structure, biological functions, and inhibitor development.
SET domain-containing protein 2 (SETD2) is the only methyltransferase that catalyzes the trimethylation of lysine at position 36 of histone H3 (H3K36me3), playing a vital role in correcting base mismatches and repairing DNA damage during ge…
FULLTEXT: Position statement -
Deubiquitination-driven adaptive programs in hepatocellular carcinoma: The emerging role of USP22 in hypoxia, metabolic rewiring, and drug resistance.
Hepatocellular carcinoma (HCC) is characterized by profound phenotypic plasticity and limited therapeutic durability. Despite the availability of tyrosine kinase inhibitors, chemotherapy, and immune checkpoint inhibitors, most patients even…
FULLTEXT: Position statement -
A sulfated pectin polysaccharide from Chrysanthemum morifolium induces ferroptosis in pancreatic cancer by stabilizing TFRC.
Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor with dismal prognosis. The chemotherapy effect of PDAC is limited and has severe side effects. Hence, identifying a natural leading compound with high efficacy against PDAC…
FULLTEXT: Position statement -
Particle Therapy Co-Operative Group Consensus Statement on Reirradiation With Proton Therapy for Prostate Cancer.
FULLTEXT: Position statement
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N-aminophthalimide-derived unsaturated PC reaction-assisted analysis of carbon-carbon double bond position and cis/trans isomerism in fatty acid chains based on UHPLC-ESI-MS/MS.
[BACKGROUND] Phosphatidylcholines (PCs) are key components of biological membranes and play crucial roles in key physiological processes, where the positions and cis/trans isomerism of carbon-carbon double bonds (CC) in fatty acyl chains cr…
FULLTEXT: Position statement -
Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions.
The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathop…
FULLTEXT: Position statement -
Harnessing hitchhikers: Outer membrane vesicles leading the way in advanced cancer therapeutics and diagnostic- A review.
TL;DRHow engineered OMVs can be used to modulate tumor metabolism, immune responses, and therapy sensitivity is discussed and how integration with lipidomics, systems biology, and artificial intelligence-guided design may imp…
FULLTEXT: Position statement