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Genetic relationships between the gut microbiota and prostate cancer: Mendelian randomization combined with bioinformatics analysis.
[BACKGROUND] Prostate cancer (PCa) is a leading cause of male cancer-related death globally. While the gut microbiota is linked to PCa, its genetic association remains unclear. [METHODS] We screened genetic instruments related to the gut m…
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Intelligent plant exosomes synergize miRNAs and cisplatin for spatiotemporally precise multimodal treatment for TNBC with high safety.
Triple-negative breast cancer (TNBC) lacks common receptors and exhibits aggressive behavior, limiting treatment options due to drug resistance and systemic toxicity. TNBC chemotherapy is hindered by poor tumor targeting, drug resistance, a…
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A self-assembled fluorescent contrast agent for imaging-guided simultaneous resection of breast tumors and metastatic lymph nodes in surgery.
Accurate intraoperative margin assessment and reliable detection of metastatic sentinel lymph nodes (SLNs) remain critical challenges in breast cancer surgery. We developed sa-FCA, a novel XIAP-targeting near-infrared fluorescent probe that…
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Strategic modification of outer branched side chains in multi-modal phototheranostic nanoplatform for synergistic breast cancer therapy.
Multi-modal imaging guided photothermal therapy (PTT) combined with photodynamic therapy (PDT) has shown significant advantages in breast cancer treatment. However, the development of superior phototheranostic nanoagents remains highly chal…
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Regulatory role of MRTF-A in macrophage polarization and the therapeutic mechanism of Bushen Wenyang Huayu decoction in endometriosis.
[ETHNOPHARMACOLOGICAL RELEVANCE] Traditional Chinese Medicine (TCM) offers multiple advantages in the treatment of endometriosis (EMS). Bushen Wenyang Huayu Decoction (BWHD) is widely used in clinical practice for managing EMS. It can signi…
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Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.
Restoring the tumor suppressive activity of the Hippo signaling pathway lost through dysregulation of the NUAK1/2 and MARK2/3 kinase axis and downstream transcriptional effectors YAP/TAZ has emerged as a new modality for the treatment of se…
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Outcome and safety of SBRT in centrally and ultra-centrally located lung tumours: A PRISMA-based systematic review and Meta-Analysis.
[INTRODUCTION] Stereotactic Body Radiation Therapy (SBRT) offers a curative treatment option for patients with early-stage central and ultra-central lung tumours, however can be associated with severe side effects. This review provides a st…
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Rutin targets PD-L1 for the treatment of atopic dermatitis: network pharmacological analysis and experimental evidence.
[BACKGROUND] Atopic dermatitis (AD) is a chronic inflammatory skin disease with high prevalence, recalcitrant nature, and significant socio-economic burden. Rutin, a bioactive flavonoid abundant in traditional medicinal plants, has document…
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Tumour lysis syndrome in the setting of a high-grade B-cell lymphoma with primary bone marrow localization - a case report.
Tumour lysis syndrome (TLS) is an oncologic emergency usually arising after chemotherapy administration, caused by a massive tumour breakdown and characterized by a specific laboratory and clinical findings. We present a case of TLS, both s…
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Arenobufagin suppresses lung cancer cell growth by disrupting mitochondrial function and inducing relocalization of ATP synthase.
Lung cancer has the highest incidence and mortality rates among all cancers worldwide. Arenobufagin, a steroidal lactone of the bufadienolide class, has been reported to possess anti-tumor activity and to inhibit Na/K-ATPase. In this study,…
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Celastrol inhibits the immune escape and proliferation of triple - negative breast cancer (TNBC) through the LKB1 - AMPK - PD-L1/MYC signaling pathway.
[BACKGROUND] Celastrol can effectively inhibit tumor proliferation and interfere with the process of tumor immune escape, but the specific regulatory pathways remain unclear. This study explored the regulatory mechanisms related to celastro…
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Optimization of strain-correlated electronic modulation and interfacial microenvironment for oxide-shielded PdGa nanosheets toward bifunctional electrocatalysis.
A critical challenge hindering the commercial application of direct methanol fuel cells (DMFCs) as highly promising energy conversion devices lies in the CO intermediates strongly adsorbed on catalyst surfaces leading to catalyst poisoning.…
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Convolutional neural networks for prostate cancer detection, classification, and segmentation: A systematic review and bibliometric analysis.
TL;DRCNN-based prostate cancer detection, classification, and segmentation demonstrate promise for improving diagnostic accuracy and clinical workflow efficiency, though challenges in dataset standardization, regulatory compl…
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Exosomal ZFPL1 Identifies Neuroendocrine and Stem Cell-Like Prostate Cancer Subtypes?
TL;DRZFPL1 is a CT- and androgen-regulated protein selectively expressed in malignant prostate cells and secreted via exosomes, highlighting its promise as a non-invasive biomarker for PC detection and monitoring.
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Spatial Robustness of Prostate Cancer Biomarkers Evaluated by Spatial Transcriptomics.
[BACKGROUND] Prognostic biomarker panels identified through bulk sequencing approaches have shown utility in localized prostate cancer but are limited by underlying molecular heterogeneity. Spatial transcriptomics offers a complementary app…
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TIMM23-ERAL1 Axis: A novel regulator of mitochondrial apoptosis in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy of the digestive system characterized by increasing global incidence and mortality rates. Translocase of the Inner Mitochondrial Membrane 23 (TIMM23), a key component of the m…
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N-aminophthalimide-derived unsaturated PC reaction-assisted analysis of carbon-carbon double bond position and cis/trans isomerism in fatty acid chains based on UHPLC-ESI-MS/MS.
[BACKGROUND] Phosphatidylcholines (PCs) are key components of biological membranes and play crucial roles in key physiological processes, where the positions and cis/trans isomerism of carbon-carbon double bonds (CC) in fatty acyl chains cr…
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Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability.
Drug resistance is a leading cause of cancer treatment failure and tumor recurrence. Identifying new methods that eliminate life-threatening drug-resistant cancer cells (DRCs) can enhance tumor cell eradication and improve patient outcomes.…
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Multimodal synergistic effects and theranostic integration of hafnium-based nanoradiosensitizers for enhancing precision radiotherapy.
TL;DRHf's critical role in redefining precision radiotherapy is highlighted and a roadmap for next-generation oncological intervention is delineated, highlighting a roadmap for next-generation oncological intervention.
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Epitranscriptomic signatures of malignancy: how RNA modifications shape breast and ovarian tumor progression.
TL;DRHow decoding of epitranscriptomic signatures of malignancy can help transform the concept of tumor biology and provide with new avenues of diagnosis, prognosis, and targeted therapy options of breast and ovarian malignan…
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