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[BACKGROUND] Prostate cancer (PCa) is a leading cause of male cancer-related death globally. While the gut microbiota is linked to PCa, its genetic association remains unclear. [METHODS] We screened genetic instruments related to the gut m…

Triple-negative breast cancer (TNBC) lacks common receptors and exhibits aggressive behavior, limiting treatment options due to drug resistance and systemic toxicity. TNBC chemotherapy is hindered by poor tumor targeting, drug resistance, a…

Accurate intraoperative margin assessment and reliable detection of metastatic sentinel lymph nodes (SLNs) remain critical challenges in breast cancer surgery. We developed sa-FCA, a novel XIAP-targeting near-infrared fluorescent probe that…

Multi-modal imaging guided photothermal therapy (PTT) combined with photodynamic therapy (PDT) has shown significant advantages in breast cancer treatment. However, the development of superior phototheranostic nanoagents remains highly chal…

[ETHNOPHARMACOLOGICAL RELEVANCE] Traditional Chinese Medicine (TCM) offers multiple advantages in the treatment of endometriosis (EMS). Bushen Wenyang Huayu Decoction (BWHD) is widely used in clinical practice for managing EMS. It can signi…

Restoring the tumor suppressive activity of the Hippo signaling pathway lost through dysregulation of the NUAK1/2 and MARK2/3 kinase axis and downstream transcriptional effectors YAP/TAZ has emerged as a new modality for the treatment of se…

[INTRODUCTION] Stereotactic Body Radiation Therapy (SBRT) offers a curative treatment option for patients with early-stage central and ultra-central lung tumours, however can be associated with severe side effects. This review provides a st…

[BACKGROUND] Atopic dermatitis (AD) is a chronic inflammatory skin disease with high prevalence, recalcitrant nature, and significant socio-economic burden. Rutin, a bioactive flavonoid abundant in traditional medicinal plants, has document…

Tumour lysis syndrome (TLS) is an oncologic emergency usually arising after chemotherapy administration, caused by a massive tumour breakdown and characterized by a specific laboratory and clinical findings. We present a case of TLS, both s…

Lung cancer has the highest incidence and mortality rates among all cancers worldwide. Arenobufagin, a steroidal lactone of the bufadienolide class, has been reported to possess anti-tumor activity and to inhibit Na/K-ATPase. In this study,…

[BACKGROUND] Celastrol can effectively inhibit tumor proliferation and interfere with the process of tumor immune escape, but the specific regulatory pathways remain unclear. This study explored the regulatory mechanisms related to celastro…

A critical challenge hindering the commercial application of direct methanol fuel cells (DMFCs) as highly promising energy conversion devices lies in the CO intermediates strongly adsorbed on catalyst surfaces leading to catalyst poisoning.…

TL;DRCNN-based prostate cancer detection, classification, and segmentation demonstrate promise for improving diagnostic accuracy and clinical workflow efficiency, though challenges in dataset standardization, regulatory compl…

TL;DRZFPL1 is a CT- and androgen-regulated protein selectively expressed in malignant prostate cells and secreted via exosomes, highlighting its promise as a non-invasive biomarker for PC detection and monitoring.

[BACKGROUND] Prognostic biomarker panels identified through bulk sequencing approaches have shown utility in localized prostate cancer but are limited by underlying molecular heterogeneity. Spatial transcriptomics offers a complementary app…

Hepatocellular carcinoma (HCC) is a highly aggressive malignancy of the digestive system characterized by increasing global incidence and mortality rates. Translocase of the Inner Mitochondrial Membrane 23 (TIMM23), a key component of the m…

[BACKGROUND] Phosphatidylcholines (PCs) are key components of biological membranes and play crucial roles in key physiological processes, where the positions and cis/trans isomerism of carbon-carbon double bonds (CC) in fatty acyl chains cr…

Drug resistance is a leading cause of cancer treatment failure and tumor recurrence. Identifying new methods that eliminate life-threatening drug-resistant cancer cells (DRCs) can enhance tumor cell eradication and improve patient outcomes.…

TL;DRHf's critical role in redefining precision radiotherapy is highlighted and a roadmap for next-generation oncological intervention is delineated, highlighting a roadmap for next-generation oncological intervention.

TL;DRHow decoding of epitranscriptomic signatures of malignancy can help transform the concept of tumor biology and provide with new avenues of diagnosis, prognosis, and targeted therapy options of breast and ovarian malignan…