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Increasing evidence suggests that Graves' disease (GD) may increase the risk of thyroid cancer (THCA), but diagnostic biomarkers associated with it remain underexplored. To address this issue, we analyzed the Gene Expression Omnibus (GEO) a…

[OBJECTIVES] Dysregulation of apoptosis-related genes (ARGs) may contribute to tumorigenesis and impact patient prognosis, but their specific influence on prognosis and immune characteristics in diffuse large B-cell lymphoma (DLBCL) remains…

[AIMS] Early detection of hepatocellular carcinoma (HCC) in patients with compensated cirrhosis (CC) is critical for improving prognosis. The GAAD algorithm (gender [biological sex], age, alpha-fetoprotein [AFP], protein induced by vitamin …

[BACKGROUND] Determination of estrogen receptor (ER) and progesterone receptor (PR) status is critical for breast cancer subtyping and guiding endocrine therapy. Although immunohistochemistry (IHC) remains the diagnostic gold standard, it i…

Based on the surface plasmon resonance (SPR) technique, the proposed biosensor is investigated as an SPR-based sensing platform for detecting breast cancer cells, specifically MCF-7 and MDA-MB-231 cells. Developed biosensor features an octa…

TL;DRThe combined model, integrating habitat quantitative parameters, CA19-9 and rim-enhancement, provides a noninvasive approach for predicting the risk of recurrence in PDAC preoperatively and could be used to quantitative …

TL;DRA fully automated deep learning‐driven postprocessing pipeline for multiparametric renal MRI, enabling accurate kidney alignment, segmentation, and quantitative feature extraction within a single efficient workflow is de…

TL;DRThe modified CEUS LI-RADS TRA emphasizing intralesional washout in LR-TR viable significantly improved specificity without compromising sensitivity and performed well in detecting LTP in ablated HCC.

[BACKGROUND] Bisphenol A (BPA), an industrial compound widely used in plastics and food packaging, has been implicated in the development of various diseases. This study aims to elucidate the molecular toxicity mechanisms of BPA in hepatoce…

Accurately identifying the mediastinal regions where metastatic lymph nodes are located is critical for the staging diagnosis of lung cancer. This identification task involves two distinct detection dimensions: mediastinal region identifica…

[BACKGROUND] Defining lines of therapy (LoTs) in real-world data is challenging, but it is essential for understanding the evolving treatment landscape for metastatic non-small-cell lung cancer (NSCLC). Validated algorithms are critical for…

[BACKGROUND] Compared to non-triple-negative breast cancer (Non-TNBC), triple-negative breast cancer (TNBC) exhibits significantly poorer prognosis. Previous research has confirmed that the PI3K/AKT pathway is closely associated with progno…

Breast cancer (BRCA) heterogeneity necessitates robust prognostic biomarkers. Programmed cell death (PCD) serves a key role in tumor progression and therapy response. However, the prognostic potential of PCD-related genes (CRGs) in BRCA rem…

High mammographic density is a well-known risk factor for breast cancer and reduces the sensitivity of mammography-based screening. While automated machine and deep learning-based methods provide more consistent and precise measurements com…

Triple-negative breast cancer (TNBC) is characterized by the lack of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2 overexpression. Historically, treatment options for TNBC have been limited, bec…

Long-read whole-transcriptome sequencing (WTS) has the potential to precisely characterize fusion oncogenes that drive leukemia and other cancers. Although there is a variety of general-purpose fusion detection algorithms that use modern lo…

BTK inhibitors (BTKi) have reshaped the therapeutic algorithm of lymphoproliferative diseases, but class-specific adverse events (AEs) have emerged. Dose adjustment (DA) is often attempted to mitigate AEs, particularly with ibrutinib, the f…

Leukemia is a type of blood cancer affecting people of all ages and is the leading cause of death worldwide. The most common form of bone marrow leukemia is acute lymphoblastic leukemia (ALL). Diagnoses often require highly invasive diagnos…

TL;DRPET reporters are recommended to use the PROMISE algorithm, while being mindful of common pitfalls related to the Gleason score, tracer used and anatomical localisation of indeterminate bone findings.

[BACKGROUND] Prostate cancer (PCa) diagnosis has historically relied on prostate-specific antigen (PSA) testing. Although PSA screening significantly reduces mortality rates, it is limited by its low specificity and the risk of overdiagnosi…