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Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in adults. Although the development and application of novel therapeutic agents have improved patient survival, primary drug resistance and the managem…

TL;DRThe results indicated that patients in the high-risk subgroup of BRCA patients had a worse prognosis, higher TMB, stronger immune response, and greater sensitivity to immunotherapy.

Cancer stands as a significant contributor to global mortality. Innovative and targeted strategies, particularly the design of purposeful nanostructures with multifunctional applications, have gained interest in chemo-radiotherapy. This app…

Insufficient lymphocyte infiltration in the tumor microenvironment is a major cause of resistance to immunotherapy. Previous studies have indicated that NLRP3 inflammasome activation is crucial for lymphocyte infiltration and activation, bu…

Cancer is one of the leading causes of mortality all across the world, and the clinical applications of numerous chemotherapeutic agents are limited by major side effects. Among these, methotrexate (MTX) is a widely used anticancer drug whi…

A novel indole-fused benzimidazole fluorescent probe, , was designed, synthesized, and characterized for selective imaging of intracellular lipid droplets (LDs) in human breast cancer cells (MDA-MB-231). The probe was prepared via condensat…

Oncogene activation is a key driver of cancer development, inducing aberrant cellular proliferation and DNA replication stress. This in turn, leads to DNA damage-which accumulates in specific genomic regions-contributing to genomic instabil…

[UNLABELLED] The exploration for novel naturally derived anticancer therapeutics characterized by minimal adverse effects is garnering widespread attention on a global scale. Consequently, the ongoing research focuses on exploring new and e…

Lactic acid bacteria isolated from kimchi include beneficial microorganisms with diverse health-promoting properties. Among these, has attracted attention owing to its potential anticancer effects. In this study, we investigated the antica…

Efficient nuclear delivery of CRISPR/Cas ribonucleoproteins (RNP) remains a significant hurdle for non-viral systems. To address this, we developed a polymer-lipid hybrid nanoparticle functionalized with the AS1411 aptamer, targeting nucleo…

Pancreatic cancer often referred to as the "king of cancers," is a disease with no symptoms and lacks effective therapy. Current treatment options for pancreatic cancer have not been successful, highlighting the need for new therapeutic ave…

Merremia tridentata of the Convolvulaceae family exhibits multiple therapeutic properties and is commonly utilized in ethnomedicine. The anti-cancerous property of M. tridentata ethyl acetate extract (MtEAE) was evaluated in HepG2 hepatocel…

Globally, hepatocellular carcinoma (HCC) is among the most commonly diagnosed cancers presenting complex treatment modalities. However, the side effects associated with conventional HCC therapeutics are quite detrimental, emphasizing the ne…

The second most prevalent cause of mortality worldwide is cancer. Pancreatic cancer, known as the "king of cancers" due to its unfavorable prognosis and absence of symptoms, is among the fatal types of cancer. Despite the availability of va…

Lung and colorectal cancers are malignancies ranked as the leading cause of cancer-related mortality worldwide. Their high mortality rate is closely associated with drug resistance driven by cancer cell heterogeneity. One of the major contr…

The objective of this study was to isolate and characterize a cytotoxic compound from the hydromethanolic extract of Roxb. ex DC. leaves using the cold percolation technique. Thin-layer chromatography was employed to isolate the cytotoxic …

[BACKGROUND] Multiplex immunofluorescence imaging enables detailed characterization of the tumor immune microenvironment, but whether immune cell densities add prognostic value beyond established clinical factors in non-small cell lung canc…

Two novel Cu(II) Schiff base complexes were synthesized using aroyl-hydrazone ligands containing pyrrole (Complex 1) and furan (Complex 2) moieties and characterized through FTIR, UV-Vis, EPR, ESI-MS, and NMR spectroscopy, supported by DFT …

[BACKGROUND] EA exhibits anti-cancer potential, limited by bioavailability and solubility. This study evaluated gamma irradiation's effects on EA, characterizing structural and morphological changes, and assessing enhanced selective cytotox…

The eco-friendly synthesis of silver nanoparticles (AgNPs) utilizing medicinal flora presents a viable strategy for the development of multifunctional agents exhibiting antimicrobial, antioxidant, anti-inflammatory, and anticancer propertie…