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[BACKGROUND] Cell-free fat extract (CEFFE) has shown promising therapeutic effects on osteoarthritis (OA) in preclinical studies, but its clinical role remains unclear. [PURPOSE] To evaluate the safety and efficacy of intra-articular autol…

TL;DRFFCA preserves structural integrity and integrates with surrounding tissue but exhibits lower cellular viability than autografts, while it may represent a useful alternative in rhinoplasty, further studies are required t…

TL;DRAG demonstrated greater structural stability and a more robust cellular response compared to HA, suggesting that AG may offer a more durable and biologically active alternative to HA in subcutaneous filler applications.

TL;DRShort-term storage of autologous septal cartilage at -40 °C without a preservative maintains substantial histological and cellular integrity, Nonetheless, longer storage durations lead to gradual ECM degradation and decr…

[BACKGROUND] Recombinant human collagen peptides (rhCol peptides) have demonstrated considerable promise in various biomedical applications, including wound healing, dermatological treatments, aesthetic procedures, cosmetic formulations, an…

TL;DRA 5‐week clinical trial was conducted to demonstrate efficacy and safety for post‐surgical skin wound healing (following pre‐conditioning, and overall skin health), and overall skin health.

TL;DRIn this rat model, the whole wrapping technique led to a greater increase in intraprosthetic pressure due to radiation-related structural changes in ADM, compared to the anterior-tenting technique.

[BACKGROUND] Cell-assisted acellular adipose matrix (AAM) transfer is a novel technique for soft tissue volume restoration, where AAM acts as a scaffold for tissue proliferation and promotes host cell migration, vascularization, and adipoge…

Calcium hydroxylapatite (CaHA) is widely used in aesthetics for its dual role as a dermal filler and biostimulator, promoting collagen and elastin synthesis. This study evaluates the comparative potential of CaHA in conventional saline dilu…

TL;DRInsight is provided into the development of next-generation implants that can harmoniously integrate with the body, minimizing FBR and ensuring long-term clinical success, and promising strategies to modulate FBR and enh…

TL;DRPorcine ADM performs clinically in a similar manner to human ADM, albeit with minor differences in cellular ingrowth and vascularization, suggesting that it may be an alternative to human ADM in prepectoral breast recons…

TL;DRCellular therapies such as tissue-derived tenocyte-like cells and MSC show a promising ability to regulate degenerative processes by modulating tissue response to inflammation and preventing continuous degradation and su…

TL;DRGiven the reduced levels of inflammatory and vascular components within the dense, fibrous capsular tissue, PU-coated breast implants are considered to be viable alternatives for capsular flaps in revisional surgery and …

TL;DRDermgraft and AWT approaches resulted in the highest patient satisfaction for the non-surgical correction of the saddle nose deformity and cellular treatments show the best maintenance of patient satisfaction over time.

[BACKGROUND] Hyaluronic acid dermal fillers are composed of cross-linked viscoelastic particles with high biocompatibility. The performance of the fillers is determined by the viscoelastic properties of particles and the connecting force be…

When first described for breast reconstruction, the presence of acellular dermal matrices was associated with increased seroma formation and infection. However, clinical safety data have gradually improved with surgeon experience to an acce…

Hyaluronic acid-based hydrogels (Hyal-Gels) have the potential to reduce wrinkles by physically volumizing the skin. However, they have limited ability to stimulate collagen generation, thus warranting repeated treatments to maintain their …

Traditional gamma-irradiated allograft costal cartilage used for cartilage-depleted rhinoplasty patients contains cellular remnants that are potentially responsible for immunological stimulation and graft resorption. To determine whether d…

The management of hard-to-heal wounds is a significant clinical challenge. Acellular dermal matrices (ADMs) have been successfully introduced to enhance the healing process. Here, we aimed to develop protocol for the preparation of novel AD…

On account of the poor biocompatibility of synthetic prosthesis, millions of rhinoplasty recipients have been forced to choose autologous costal cartilage as grafts, which suffer from limited availability, morbidity at the donor site and pr…