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Chondrocyte proliferation without inflammation underlies botulinum toxin-induced mandibular enthesis bone hypertrophy in rats.
TL;DRBTX-related muscle atrophy of masticatory muscle induced chondrocyte proliferation at enthesis without inflammation process and BTX-related muscle atrophy of masticatory muscle induced chondrocyte proliferation at enthes…
FULLTEXT: Cellular Reprogramming -
A 15-Year Computational Twin Modeling Study of Botulinum Toxin A Frequency and Age-Related Facial Aging.
TL;DRIt is demonstrated that while BoNTA effectively softens dynamic lines in the short term, it does not alter the underlying trajectory of intrinsic aging, and long-term facial outcomes appear governed primarily by biologic…
FULLTEXT: Cellular Reprogramming -
Safety and Efficacy of Intra-articular Cell-Free Fat Extract Injection in Patients With Symptomatic Knee Osteoarthritis.
[BACKGROUND] Cell-free fat extract (CEFFE) has shown promising therapeutic effects on osteoarthritis (OA) in preclinical studies, but its clinical role remains unclear. [PURPOSE] To evaluate the safety and efficacy of intra-articular autol…
FULLTEXT: Cellular Reprogramming -
Investigating the Influence of Tranexamic Acid on Adipocyte Differentiation in an In Vitro Model.
[BACKGROUND] Tranexamic acid (TXA) is widely used in plastic surgery to reduce perioperative blood loss, hematoma formation, and postoperative ecchymosis. Its incorporation into tumescent solution for liposuction and fat grafting has increa…
FULLTEXT: Cellular Reprogramming -
Peptides in Facial Plastic Surgery: Emerging Applications in Aesthetics and Rejuvenation.
TL;DRCurrent evidence and proposed mechanisms to help guide informed discussions and clinical decision-making in facial plastic surgery practice are presented to help guide informed discussions and clinical decision-making in…
FULLTEXT: Cellular Reprogramming -
Oleuropein in Nasal Epithelial Cells: A Breakthrough Candidate for Anti-Inflammatory Topical Therapy.
TL;DRAt lower concentrations, oleuropein may promote wound healing in nasal epithelial cells without causing cytotoxicity, which could pave the way for the development of novel topical medicines to aid healing after septoplas…
FULLTEXT: Cellular Reprogramming -
Pumpkin Seed Oil as a Candidate Intranasal Delivery Medium: Evidence From Nasal Epithelial Cell Culture.
TL;DRIn vitro evidence supports potential low-concentration ENT applications of C. pepo seed oil and shows potential for the use of C. pepo seed oil as a locally applied, biologically active substance.
FULLTEXT: Cellular Reprogramming -
The Effect of Platelet-Rich Fibrin on Block, Crushed and Diced Cartilage.
TL;DRPRF enhanced the viability, proliferation, and angiogenic response of autologous cartilage grafts through its sustained release of growth factors and scaffold-like fibrin matrix, suggesting that PRF may improve graft sta…
FULLTEXT: Cellular Reprogramming -
A Translational Cell-Culture Study of Jojoba Oil: Potential Uses and Safety Considerations for Nasal Applications.
TL;DRThe viability and proliferation of nasal epithelial cells are reduced in a dose-dependent manner when exposed directly to Simmondsia chinensis seed oil, indicating that the oil's cytotoxic effects were strongly concentra…
FULLTEXT: Cellular Reprogramming -
Resveratrol Suppresses Sepsis-Induced Micro-vascular Hypo-reactivity Through Rac1-MLCK Pathway.
TL;DRRes suppressed sepsis-induced microvascular hyporeactivity through the Rac1-MLCK pathway, providing insights into the treatment of vascular hyporeactivity during sepsis.
FULLTEXT: Cellular Reprogramming -
Abdominal Wall Reinforcement Using OviTex after Deep Inferior Epigastric Perforator Flap.
TL;DRThis study demonstrates that OviTex mesh is safe and efficacious in reducing the rate of bulges following DIEP flap harvest without increasing other complications.
FULLTEXT: Cellular Reprogramming -
A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies.
TL;DRThe clinical relevance of the most important clocks and biomarkers used in skin anti-ageing strategy evaluation, the fundamentals, the main illustrating examples preclinically and clinically tested, the critical insights…
FULLTEXT: Cellular Reprogramming -
A Prospective, Randomized, Double-Blind, Split-Face Trial Evaluating the Effects of Pre-Conditioning With a TriHex Technology Serum Nectar 2.0 Versus a Vehicle in Subjects Undergoing Elective Facelift Surgery.
TL;DRA 5‐week clinical trial was conducted to demonstrate efficacy and safety for post‐surgical skin wound healing (following pre‐conditioning, and overall skin health), and overall skin health.
FULLTEXT: Cellular Reprogramming -
Stemness and clinical performance of water-jet technology: A translational study in breast reconstruction.
TL;DRThe hypothesis that Body-Jet–based liposuction yields biologically viable and regenerative lipoaspirates, while offering favorable clinical tolerability, is supported.
FULLTEXT: Cellular Reprogramming -
High-Throughput Molecular Characterization of the Microbiome in Breast Implant-Associated Anaplastic Large Cell Lymphoma and Peri-Implant Benign Seromas.
TL;DRInvestigating the microbiota in late-onset seromas from 10 BIA-ALCL patients and 12 with a non-neoplastic effusion found no single bacterial species or family specifically associated with BIA-ALCL, and suggests that BIA-…
FULLTEXT: Cellular Reprogramming -
Donor site healing in follicular unit extraction hair transplantation: current evidence, cellular mechanisms, and future research directions.
TL;DRA critical gap is identified in mechanistic studies exploring the cellular dynamics of donor area healing, including the roles of keratinocytes, fibroblasts, and immune cells, which may inform evidence-based protocols th…
FULLTEXT: Cellular Reprogramming -
Cells and Shells: Investigating How Breast Implant Shells Negatively Impact Cell Viability In Vitro.
TL;DRThese studies suggest breast implant shells may negatively impact cell viability through several different mechanisms and uncover valuable insights into the cellular interactions and potential effects of these widely use…
FULLTEXT: Cellular Reprogramming -
Optimization of autologous adipose tissue transplantation: The impact of patient-specific and intraoperative factors on cellular viability before and after cryopreservation.
TL;DRThe findings underscore the need to evaluate adjuvant therapies when planning adipose tissue collection, and Optimizing timing and preparation can improve graft viability, reducing resorption rates and enhancing volumizi…
FULLTEXT: Cellular Reprogramming -
CELT Fat Increases the Metabolic Activity as Well as the SVF-Yield Significantly When Compared to CELT Fat, Even After Cryopreservation with DMSO.
TL;DRIt is found that freezing CELTPLUS fat with DMSO yields better results than without cryoprotection in all evaluated methods, and until non-toxic cryoprotective agents are tested on CELTPLUS fat, it is not recommend initi…
FULLTEXT: Cellular Reprogramming -
Engineered Exosomes Complexed with Botulinum Toxin Type A for Enhanced Anti-Aging Effects on Skin.
TL;DRA new and safer method for using BTX-A by attaching it to tiny natural particles called exosomes, which are produced by stem cells, which are specially designed to carry a protein that helps them bind BTX-A more effectiv…
FULLTEXT: Cellular Reprogramming