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Hsa_circ_0002111 is highly expressed in papillary thyroid carcinoma (PTC). We therefore investigated its role and underlying mechanism in promoting PTC progression. Q-RT-PCR, dual-luciferase reporter assays, AGO2-RIP, CCK-8, colony formatio…

S-phase kinase-associated protein 2 (SKP2) functions as a dual-ubiquitin modulator in breast cancer progression by orchestrating two distinct ubiquitination process. Through Ub-K48-linked degradation, SKP2 facilitates proteasomal turnover o…

TL;DREffective in vivo delivery of saRNAs is achieved using various delivery systems, including lipid nanoparticles, aptamers, dendrimers, and lipopolyplexes, enabling the guide strand to direct AGO2 to the nucleus and activa…

TL;DRThese computationally prioritized high risk SNPs of FZD8 can be investigated in population based genetic studies and may serve as potential targets for future drug development against FZD8-associated diseases.

NSUN2-dependent RNA mC methylation is essential for RNA stability, cellular metabolism, and intracellular transport. Aberrant YAP expression is closely associated with tumorigenesis and progression in human cancers. However, the molecular m…

We compared daunorubicin/cytarabine plus fractionated gemtuzumab ozogamicin (DAGO2) with CPX-351 (CPX; 1:2 randomization) in 439 patients with acute myeloid leukemia (AML) aged ≥60 years (median age, 68 years) without known adverse-risk cyt…

Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies and poor prognosis. Unc-51-like kinase 1 (ULK1), a central regulator of autophagy, has emerged as a potential therapeutic node in cancer but remai…

[BACKGROUND] Early-stage gastric cancer (GC) is often asymptomatic, leading to frequent late-stage diagnoses. There is a critical need for non-invasive biomarkers to improve early detection and preoperative risk assessment. Although tRNA-de…

Cancer is a complex disease characterized by uncontrolled cell proliferation and metastasis, with breast cancer remaining a leading cause of mortality among women worldwide. Hypoxia-inducible factor (HIF) and vascular endothelial growth fac…

[BACKGROUND/AIM] Pancreatic adenocarcinoma (PAAD) is an aggressive cancer type with high mortality rates. The Argonaute (AGO) gene/protein family is an evolutionary conserved family, which is responsible for post-transcriptional regulation …

Colorectal cancer (CRC) ranks as the third most common cancer globally and is characterized by a poor prognosis. Abnormal glycosylation, a hallmark of cancer development, influences multiple signaling pathways and contributes to CRC progres…

Despite the use of FMS-like tyrosine kinase 3 (FLT3) inhibitors, outcomes for patients with FLT3-mutated (FLT3mut) acute myeloid leukemia (AML) remain suboptimal because of high rates of relapse. We evaluated the safety and efficacy of the …

[BACKGROUND] Peritoneal metastasis, the most common mode of dissemination in gastric cancer (GC), is characterized by resistance to treatment and a poor prognosis. Accumulating evidence indicates that circular RNAs (circRNAs) play a signifi…

: Prostate cancer, an epithelial malignancy occurring in the prostate, is the most common malignant tumor of the male genitourinary system and has a low survival rate in advanced prostate cancer after metastasis. It is urgent to explore nov…

DROSHA protein is widely known for its essential role in the microRNA (miRNA/miR) biogenesis pathway where, together with its co-factor DGCR8, it forms the "Microprocessor" complex and catalyzes the primary miRNA (pri-miRNA) processing in t…

Gastric cancer (GC) is one of the most common malignancies with a poor prognosis. The development of novel biomarkers is of utmost importance to screen patients with GC. Molecular mechanism study of GC may provide a research basis for the d…

[BACKGROUND/AIM] Periodontitis is a prevalent multifactorial, oral infectious disease and is considered a high-risk factor for pancreatic cancer. Nevertheless, there is limited understanding of the underlying epigenetic mechanisms governing…

[BACKGROUND] Pancreatic cancer (PC) has been one of the most severe digestive system malignant tumor with poor prognosis that threatens human health. Chemotherapy is essential for patients with advanced PC, but unfortunately the curative ef…

Hypoxia, or low oxygen tension, is frequently found in highly proliferative solid tumors such as anaplastic thyroid carcinoma (ATC) and is believed to promote resistance to chemotherapy and radiation. Identifying hypoxic cells for targeted …

Long noncoding RNA (lncRNA), a subgroup of noncoding RNA with > 200 nt, plays critical roles in cancer progression. Here, we aimed to explore the detailed biological function of lncRNA EGFEM1P during papillary thyroid cancer (PTC) progressi…