Low-dose Radiation Therapy Concurrent With Atezolizumab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer: 3-Year Follow-up of a Multicenter, Single-arm, Phase 2 Trial (MATCH).
[PURPOSE] Preclinical studies showed that low-dose radiation therapy (LDRT) may act synergistically with immunotherapy in small cell lung cancer (SCLC); however, its role in the treatment of extensive
- 95% CI 75.9-94.8
- 추적기간 36.1 months
APA
Zhou L, Sun J, et al. (2026). Low-dose Radiation Therapy Concurrent With Atezolizumab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer: 3-Year Follow-up of a Multicenter, Single-arm, Phase 2 Trial (MATCH).. International journal of radiation oncology, biology, physics, 124(1), 164-173. https://doi.org/10.1016/j.ijrobp.2025.06.3872
MLA
Zhou L, et al.. "Low-dose Radiation Therapy Concurrent With Atezolizumab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer: 3-Year Follow-up of a Multicenter, Single-arm, Phase 2 Trial (MATCH).." International journal of radiation oncology, biology, physics, vol. 124, no. 1, 2026, pp. 164-173.
PMID
40609842
Abstract
[PURPOSE] Preclinical studies showed that low-dose radiation therapy (LDRT) may act synergistically with immunotherapy in small cell lung cancer (SCLC); however, its role in the treatment of extensive-stage SCLC (ES-SCLC) remains unclear.
[METHODS AND MATERIALS] This single-arm, multicenter, Simon's 2-stage, phase 2 study enrolled treatment-naïve patients with ES-SCLC. Patients received 4 21-day cycles of intravenous cisplatin (75 mg/m) or carboplatin (area under the curve value, 5 mg/mL/min), etoposide (100 mg/m), and atezolizumab (1200 mg), with concurrent LDRT (15 Gy in 5 fractions [3 Gy/fraction]), followed by atezolizumab maintenance therapy until loss of clinical benefit, unacceptable toxicity, withdrawal of consent, or death. The primary endpoint was the confirmed objective response rate. The secondary endpoints were progression-free survival (PFS) and overall survival (OS).
[RESULTS] Fifty-six eligible patients were enrolled between December 16, 2020, and March 30, 2022. The median follow-up was 36.1 months (IQR, 30.9-38.7) at the cutoff date (June 30, 2024). The confirmed objective response rate was 87.5% (95% CI, 75.9-94.8). The median PFS and OS were 6.9 months (95% CI, 5.4-9.3) and 16.9 months (95% CI, 14.0-32.9), respectively. The PFS rates at 1 and 3 years were 27.3% and 20.7%, respectively, and the OS rates at 1 and 3 years were 69.6% and 35.1%. The median depth of tumor response among patients with confirmed objective response was 70.2%. The 3-year OS rates were 57.4% and 18.8% in patients above and below the median depth of tumor response, respectively (hazard ratio, 0.28; 95% CI, 0.13-0.60). The most common treatment-related grades 3 to 5 adverse events were decreased neutrophil count (60.7%) and decreased white blood cell count (58.9%).
[CONCLUSIONS] These findings suggest that upfront LDRT concurrent with atezolizumab plus chemotherapy was effective and tolerable as first-line treatment for ES-SCLC, warranting further verification in randomized controlled trials.
[METHODS AND MATERIALS] This single-arm, multicenter, Simon's 2-stage, phase 2 study enrolled treatment-naïve patients with ES-SCLC. Patients received 4 21-day cycles of intravenous cisplatin (75 mg/m) or carboplatin (area under the curve value, 5 mg/mL/min), etoposide (100 mg/m), and atezolizumab (1200 mg), with concurrent LDRT (15 Gy in 5 fractions [3 Gy/fraction]), followed by atezolizumab maintenance therapy until loss of clinical benefit, unacceptable toxicity, withdrawal of consent, or death. The primary endpoint was the confirmed objective response rate. The secondary endpoints were progression-free survival (PFS) and overall survival (OS).
[RESULTS] Fifty-six eligible patients were enrolled between December 16, 2020, and March 30, 2022. The median follow-up was 36.1 months (IQR, 30.9-38.7) at the cutoff date (June 30, 2024). The confirmed objective response rate was 87.5% (95% CI, 75.9-94.8). The median PFS and OS were 6.9 months (95% CI, 5.4-9.3) and 16.9 months (95% CI, 14.0-32.9), respectively. The PFS rates at 1 and 3 years were 27.3% and 20.7%, respectively, and the OS rates at 1 and 3 years were 69.6% and 35.1%. The median depth of tumor response among patients with confirmed objective response was 70.2%. The 3-year OS rates were 57.4% and 18.8% in patients above and below the median depth of tumor response, respectively (hazard ratio, 0.28; 95% CI, 0.13-0.60). The most common treatment-related grades 3 to 5 adverse events were decreased neutrophil count (60.7%) and decreased white blood cell count (58.9%).
[CONCLUSIONS] These findings suggest that upfront LDRT concurrent with atezolizumab plus chemotherapy was effective and tolerable as first-line treatment for ES-SCLC, warranting further verification in randomized controlled trials.
MeSH Terms
Humans; Small Cell Lung Carcinoma; Lung Neoplasms; Antibodies, Monoclonal, Humanized; Male; Middle Aged; Female; Aged; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Follow-Up Studies; Carboplatin; Cisplatin; Chemoradiotherapy; Adult; Neoplasm Staging; Radiotherapy Dosage; Progression-Free Survival
같은 제1저자의 인용 많은 논문 (5)
- Disease Self-Monitoring Behaviors and Influencing Factors Among Family Members of Patients With Digestive Tract Cancer: A Latent Profile Analysis.
- The absence of B7-H4 inhibits PD-L1 expression by driving a methylation of PD-L1 promoter in breast cancer cells.
- Integrated multi-dataset screening to predict prognosis and identify immunotherapy gene targets in hepatocellular carcinoma patients.
- Inhibits Breast Cancer Tumor Progression by Targeting to Regulate Glycolysis.
- Multimodal hybrid mamba classification model for tumor pathological grade prediction using magnetic resonance images.