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38건 · 최신순-
Extended Transoral Resection of Anterior Commissure Tumors in a Canine Model: Impact on Laryngeal Framework, Glottis, and Vocal Function.
[BACKGROUND AND OBJECTIVES] Evaluate the feasibility and functional outcomes of extended transoral resection for anterior commissure (AC) tumors in canines, focusing on laryngeal framework, airway, and vocal function. [METHODS] Twelve dogs…
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The Effects and Mechanisms of Botulinum Toxin Type A on Hypertrophic Scars and Keloids.
[BACKGROUND] Keloids and hypertrophic scars are characterized by pathologically excessive dermal fibrosis and aberrant wound healing. These pathological scars are characterized by continuous and histologically localized inflammation of the …
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Orbicularis Oculi Toxin Injection for Treating Levator Palpebrae Superioris Weakness: Clinical Effect and Safety in a Cohort Study.
[BACKGROUND] Ptosis, the drooping of the upper eyelid caused by levator palpebrae superioris muscle dysfunction, is a common condition that can impair vision and quality of life. It can arise independently or as a secondary condition to dis…
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Research Progress on Platelet-Rich Plasma (PRP) in the Treatment of Androgenetic Alopecia.
[BACKGROUND] Androgenetic alopecia (AGA) is the most common cause of progressive hair loss, significantly affecting quality of life. Current therapies, such as minoxidil, finasteride, and hair transplantation, show variable efficacy and may…
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The Clinical Application of Suzetrigine.
Acute pain affects patient's health and quality of life. Suzetrigine is a new highly selective Nav1.8 inhibitor for the treatment of moderate to severe acute pain in adults. This article aims to summarize the existing clinical results of su…
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Modified masquelet technique coupled with vascularized fibular transplantation (transposition) in the reconstruction of ultra-long structural bone defects following osteomyelitis debridement: clinical application and preliminary study on therapeutic outcomes.
[BACKGROUND AND OBJECTIVE] Chronic osteomyelitis of long diaphyseal bones often results in extensive structural bone defects following debridement. Traditional approaches such as cancellous bone grafting, fibular transplantation, the classi…
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Recombinant Detoxified Holotoxin as a Potent Candidate Vaccine Against Botulism.
Vaccination may represent a suitable strategy for preventing botulism. The recombinant expression of toxin functional domains can induce effective immune responses against botulism. This study aims to develop a safe and effective recombinan…
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Research Progress of Camptocormia in Parkinson Disease.
Camptocormia, also known as bent spine syndrome, primarily affects individuals with Parkinson disease (PD). This review provides an overview of camptocormia in PD, covering its definition, epidemiology, causes, diagnosis, and treatment. In …
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Vertical inhibition of p110α/AKT and N-cadherin enhances treatment efficacy in PIK3CA-aberrated ovarian cancer cells.
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [PIK3CA, encoding PI3Kalpha (also known as p110α)] is one of the most commonly aberrated genes in human cancers. In serous ovarian cancer, PIK3CA amplification is highly…
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Efficiency and Safety of Noninvasive and Intravesical Therapy for Adult Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.
[BACKGROUND] Neurogenic lower urinary tract dysfunction (NLUTD), a complex abnormality caused by multiple neurologic disorders, is a serious threat to patients' prognosis and quality of life. However, benefit and safety for various treatmen…
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The effect and related mechanisms of RAC1 GTP on radiotherapy for hepatocellular carcinoma.
[BACKGROUND] Ras-related C3 botulinum toxin substrate 1 (), a pivotal Rho guanosine triphosphatases (GTPase) implicated in oncogenic processes and radiotherapeutic resistance across malignancies, has not been extensively examined within the…
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Botulinum toxin A prevents hypertrophic scarring by suppressing PARP14/SOCS2-mediated M2 polarization of macrophages.
Botulinum toxin A (BTXA) is a safe and widely used neurotoxic protein in cosmetic procedures and medical applications. This investigation focuses on the function of BTXA on macrophage phenotype during hypertrophic scar (HS) formation and th…
- The key points of vessel anastomosis in free-flap reconstruction.
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Pulsatilla saponin D regulates ras-related C3 botulinum toxin substrate 3 (RAC3) to overcome resistance to paclitaxel in lung adenocarcinoma cells.
[BACKGROUND] Paclitaxel, a tubulin-binding agent, is a Food and Drug Administration-approved first-line drug for the treatment of non-small cell lung cancer (NSCLC), for both squamous and non-squamous cell lung carcinoma, with paclitaxel/ca…
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as a potential pan-cancer diagnostic, prognostic, and immunological biomarker.
[BACKGROUND] Ras-related C3 botulinum toxin substrate 1 () is an important member of the Rho GTPase family involved in tumorigenesis. However, its role and potential clinical utility across cancer entities in solid tumors is unknown. [METH…
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A Novel Approach for Treating Lipomas: Percutaneous Microwave Ablation Combined with Liposuction.
Lipomas, benign adipose tissue tumors, are a common occurrence but currently, the options for their treatment are limited, with surgical excision being the most frequently used management pathway. This scenario can often lead to unsatisfact…
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Identification of Drug Compounds for Capsular Contracture Based on Text Mining and Deep Learning.
[BACKGROUND] Capsular contracture is a common and unpredictable complication after breast implant placement. Currently, the pathogenesis of capsular contracture is unclear, and the effectiveness of nonsurgical treatment is still doubtful. T…
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Effects of anterolateral femoral free flap transplantation on the repair of soft tissue defect of hands and feet and risk factors for flap necrosis.
[OBJECTIVE] To retrospectively analyze the effect of anterolateral femoral free flap transplantation in repairing hand and foot soft tissue defects and the risk factors for skin flap necrosis. [METHODS] The clinical data of 62 patients wit…
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Safety analysis of immediate breast reconstruction with a deep inferior epigastric perforator (DIEP) flap in the post-COVID-19 era: a comparison between pre- and post-pandemic cohorts.
[BACKGROUND] The demand for immediate breast reconstruction with a deep inferior epigastric perforator (DIEP) flap is recovering as coronavirus disease 2019 (COVID-19) transitions from a pandemic to an endemic. This study sought to evaluate…
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Chemical sphincterotomy in posthemorrhoidectomy pain relief: a meta-analysis.
[PURPOSE] This study aims to evaluate the pain relief function of chemical sphincterotomy in patients undergoing haemorrhoid surgery and compare, through a meta-analysis, the different drugs used to treat this condition. [METHODS] We condu…
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Cosmetic augmentation of lower-lid pretarsal roll with injection of autologous fat for Asians.
[BACKGROUND] Autologous fat has the advantages of regeneration, rejuvenation, homology, and support. There are currently no reports indicating that injecting autologous fat enhances the fullness of the lower-lid pretarsal roll. [OBJECTIVES…
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Perioperative Low Dose Dexmedetomidine and Its Effect on the Visibility of the Surgical Field for Middle Ear Microsurgery: A Randomised Controlled Trial.
There are many benefits of administering dexmedetomidine perioperatively. The pharmacokinetics (PK) and pharmacodynamics (PD) of intravenous, intranasal and oral dexmedetomidine that was administered before anesthesia were compared in this …
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Effect of transverse wrist crease perforator flap on repairing soft tissue defect of fingers and its influence on hand function.
[OBJECTIVE] To investigate the effect of transverse wrist crease perforator flap repair on sensory nerve function, survival of flap, hand function, hand appearance and satisfaction rate in patients with soft tissue defect of fingers. [METH…
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Is myasthenia gravis a contraindication for botulinum toxin?
Botulinum toxin (BTX) is a neurotoxin that has been used to treat various disorders and has also become a popular choice for cosmetic indications, yet traditionally, myasthenia gravis (MG) is considered a contraindication for BTX. To determ…
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Advanced Glycation End Products (AGEs) Inhibit Macrophage Efferocytosis of Apoptotic β Cells through Binding to the Receptor for AGEs.
Pancreatic β cell apoptosis is important in the pathogenesis of type 2 diabetes mellitus (T2DM). Generally, apoptotic β cells are phagocytosed by macrophages in a process known as "efferocytosis." Efferocytosis is critical to the resolution…
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Reconstruction of a secondary scalp defect using the crane principle and a split-thickness skin graft.
[BACKGROUND] Scalp reconstruction is a common challenge for surgeons, and there are many different treatment choices. The "crane principle" is a technique that temporarily transfers a scalp flap to the defect to deposit subcutaneous tissue.…
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[Treatment of osteonecrosis of the femoral head with vascularized bone grafting].
[OBJECTIVE] To summarize the current progress of vascularized bone grafting in the treatment of osteonecrosis of the femoral head (ONFH), and to provide reference for treatment of ONFH. [METHODS] The literature at home and abroad on the tr…
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Management of Unsatisfactory Postoperative Double Eyelid With Intralesional Corticosteroid Injection.
The present study was designed to observe the curative effect of early intralesional corticosteroid injection to treat unsatisfactory double eyelid. This retrospective, observational study included 30 female patients (age 22-35 years) rece…
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Effect of Transcutaneous Upper Eyelid Blepharoplasty on Blink Parameters and Lipid Layer Thickness.
This study aimed to investigate the effect of transcutaneous upper eyelid blepharoplasty on lipid layer thickness (LLT) and blink parameters in young women during the early postoperative period. This prospective study included 110 eyes of …
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Accuracy of endoscopic ultrasound in rectal cancer and its use in transanal endoscopic microsurgery.
This study evaluated the accuracy of endoscopic ultrasound (EUS) for preoperative staging of rectal cancer and guiding the treatment of transanal endoscopic microsurgery (TEM) in early rectal cancer. One-hundred-twenty-six patients with rec…