[A Case Report of Successful Control of Refractory Tumor Fever in Lung Adenocarcinoma with Interleukin-6 Antibody Tocilizumab].
Fever is a common symptom of lung cancer, but most are induced by infection.
APA
Li Y, Li C, Li B (2026). [A Case Report of Successful Control of Refractory Tumor Fever
in Lung Adenocarcinoma with Interleukin-6 Antibody Tocilizumab].. Zhongguo fei ai za zhi = Chinese journal of lung cancer, 29(1), 77-80. https://doi.org/10.3779/j.issn.1009-3419.2026.102.01
MLA
Li Y, et al.. "[A Case Report of Successful Control of Refractory Tumor Fever
in Lung Adenocarcinoma with Interleukin-6 Antibody Tocilizumab].." Zhongguo fei ai za zhi = Chinese journal of lung cancer, vol. 29, no. 1, 2026, pp. 77-80.
PMID
41916917
Abstract
Fever is a common symptom of lung cancer, but most are induced by infection. This is the first report of a patient with lung adenocarcinoma who developed a fever of unknown origin for more than 1 month after repeat biopsy on the progression of first-line treatment in China. Comprehensive blood tests, the well-known pathogens were fully examined, and imaging studies failed to support infectious fever, connective tissue disease-related fever, drug fever, or other etiologies, leading to the diagnosis of tumor fever. While the fever remained refractory to Ibuprofen, it was successfully controlled 12 h after a single intravenous administration of Tocilizumab, with the patient maintaining a normal body temperature for 45 days, from August 21 to October 4, 2025. This case report primarily provides the practice for exploring the tumor fever.
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MeSH Terms
Humans; Antibodies, Monoclonal, Humanized; Adenocarcinoma of Lung; Lung Neoplasms; Fever; Interleukin-6; Male; Middle Aged; Aged; Female
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