Single-cell spatial transcriptomics reveals tumor microenvironment heterogeneity in primary and lymph node-metastatic small cell lung cancer.
2/5 보강
OpenAlex 토픽 ·
Single-cell and spatial transcriptomics
Cancer Immunotherapy and Biomarkers
Ferroptosis and cancer prognosis
Lymph node metastasis (LNM) is a critical prognostic and therapeutic determinant in small cell lung cancer (SCLC), yet its spatial cellular ecosystem remains poorly understood.
APA
Zheng Zhang, Dongfang Wu, et al. (2026). Single-cell spatial transcriptomics reveals tumor microenvironment heterogeneity in primary and lymph node-metastatic small cell lung cancer.. Cell reports. Medicine, 7(4), 102713. https://doi.org/10.1016/j.xcrm.2026.102713
MLA
Zheng Zhang, et al.. "Single-cell spatial transcriptomics reveals tumor microenvironment heterogeneity in primary and lymph node-metastatic small cell lung cancer.." Cell reports. Medicine, vol. 7, no. 4, 2026, pp. 102713.
PMID
41916294 ↗
Abstract 한글 요약
Lymph node metastasis (LNM) is a critical prognostic and therapeutic determinant in small cell lung cancer (SCLC), yet its spatial cellular ecosystem remains poorly understood. Here, we perform single-cell spatial transcriptomics using the CosMx Spatial Molecular Imager on 105 primary and metastatic lymph node specimens from 75 SCLC patients, generating a comprehensive atlas of over 600,000 cells. We identify three LNM-enriched malignant subclusters with distinct metabolic and angiogenic programs that spatially correlate with immune exclusion features. Spatial analysis reveals vascular-immune crosstalk, wherein endothelial cells orchestrate immune activation through avoidance of malignant cells while forming functional perivascular niches with cytotoxic T cells during LNM. Cellular neighborhood analysis delineates distinct multicellular niches and identifies a pan-immune hotspot (PIHs-1) whose abundance is an independent predictor of survival. This study provides a high-resolution spatial map of the SCLC tumor microenvironment during LNM and establishes spatially defined architectures as both mechanistic insights and translatable biomarkers.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Tumor Microenvironment
- Small Cell Lung Carcinoma
- Single-Cell Analysis
- Lung Neoplasms
- Lymphatic Metastasis
- Transcriptome
- Female
- Lymph Nodes
- Male
- Middle Aged
- Gene Expression Regulation
- Neoplastic
- Aged
- Gene Expression Profiling
- lymph node metastasis
- small cell lung cancer
- spatial molecular imaging
- spatial transcriptomics
- tumor microenvironment
같은 제1저자의 인용 많은 논문 (5)
- Modified Use of Costal Cartilage in Asians for the Correction of Nostril Asymmetry in Unilateral Secondary Cleft Lip Nasal Deformity.
- Unleashing CAR-T potential in solid tumors: overcoming intrinsic and extrinsic hurdles to improve therapy.
- Comparison of oncological outcomes between wedge resection and segmentectomy for T1a/bN0M0 non-small-cell lung cancer: a population-based retrospective cohort study.
- Tumor-derived C4BPA promotes macrophage M2-like polarization through C5a -C5aR1-STAT3 axis and drives gastric cancer progression.
- Innate immunity in tumour immunoediting and immunosurveillance.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.
- Early local immune activation following intra-operative radiotherapy in human breast tissue.