Spatially distinct cellular and molecular landscapes define prognosis in triple-negative breast cancer.
1/5 보강
Triple-negative breast cancer (TNBC) is a prevalent breast cancer subtype with the lowest 5-year survival.
APA
Mukund K, Veraksa D, et al. (2026). Spatially distinct cellular and molecular landscapes define prognosis in triple-negative breast cancer.. Cell reports, 45(1), 116752. https://doi.org/10.1016/j.celrep.2025.116752
MLA
Mukund K, et al.. "Spatially distinct cellular and molecular landscapes define prognosis in triple-negative breast cancer.." Cell reports, vol. 45, no. 1, 2026, pp. 116752.
PMID
41481418 ↗
Abstract 한글 요약
Triple-negative breast cancer (TNBC) is a prevalent breast cancer subtype with the lowest 5-year survival. Several factors influence outcomes, but their inherent molecular and cellular heterogeneity are increasingly acknowledged as crucial determinants. Here, we report on the spatio-molecular heterogeneity underlying TNBC tumors in a retrospective, treatment-naive cohort with differential prognoses (17 good prognoses [GPx] >15-year survival and 15 poor prognoses [PPx] <3-year survival]) profiled using GeoMx Digital Spatial Profiler. Analyses reveal that epithelial and microenvironment (TME) states are transcriptionally distinct between groups. Invasive GPx epithelia show an increase in immune transcripts, with a more immune-rich TME (via IF). PPx epithelia, in contrast, are more metabolically and translationally active, with a mesenchymal/fibrotic TME. Pre-cancerous epithelia in PPx exhibit a presence of aggressiveness, marked by increased EMT signaling and complement activity. We identify distinct epithelial gene signatures for PPx and GPx that can accurately classify diagnostic samples and likely inform therapy.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Triple Negative Breast Neoplasms
- Humans
- Female
- Prognosis
- Tumor Microenvironment
- Gene Expression Regulation
- Neoplastic
- Epithelial-Mesenchymal Transition
- Retrospective Studies
- C3 complement
- CP: cancer
- GeoMx DSP
- TNBC
- epithelia
- immune mimicry
- impressionable epithelium
- pre-cancerous
- prognosis
- triple-negative breast cancer
- tumor microenvironment
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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