Survival prognosis and influencing factors in elderly patients with stage I-III breast cancer.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: stage I-III breast cancer and to explore the related clinicopathological influencing factors
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Specifically, younger age (≤ 68 years), PR positivity, Ki-67 < 30%, and early T (T1-T2) and N (N0) stages are associated with a more favourable prognosis. [SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1186/s12957-026-04225-6.
[AIMS] To analyse the survival prognosis of elderly patients with stage I-III breast cancer and to explore the related clinicopathological influencing factors.
APA
Zeng Y, Zhang P, et al. (2026). Survival prognosis and influencing factors in elderly patients with stage I-III breast cancer.. World journal of surgical oncology, 24(1). https://doi.org/10.1186/s12957-026-04225-6
MLA
Zeng Y, et al.. "Survival prognosis and influencing factors in elderly patients with stage I-III breast cancer.." World journal of surgical oncology, vol. 24, no. 1, 2026.
PMID
41620708
Abstract
[AIMS] To analyse the survival prognosis of elderly patients with stage I-III breast cancer and to explore the related clinicopathological influencing factors.
[METHODS] Retrospective collection of clinicopathological data from elderly breast cancer patients (aged ≥ 65 years) admitted to Sichuan Cancer Hospital between October 2014 and December 2022. Survival curves were generated using the Kaplan–Meier method and comparisons were made using the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were employed to identify factors independently associated with five-year event-free survival (EFS).
[RESULTS] A total of 319 elderly patients with stage I-III breast cancer were included, with a 5-year overall EFS rate of 82.0%. Univariate analysis revealed significant associations between 5-year EFS and age, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 level, tumour size (T stage), lymph node status (N stage), and the administration of endocrine therapy (all < 0.05). Multivariate analysis revealed that age, PR status, T stage, N stage, and Ki-67 level were independent prognostic factors for 5-year EFS.
[CONCLUSIONS] The results of this study suggest that age, PR status, the Ki-67 index, tumour size, and lymph node metastasis can serve as independent predictors of the 5-year EFS rate in elderly patients with stage I-III breast cancer. Specifically, younger age (≤ 68 years), PR positivity, Ki-67 < 30%, and early T (T1-T2) and N (N0) stages are associated with a more favourable prognosis.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1186/s12957-026-04225-6.
[METHODS] Retrospective collection of clinicopathological data from elderly breast cancer patients (aged ≥ 65 years) admitted to Sichuan Cancer Hospital between October 2014 and December 2022. Survival curves were generated using the Kaplan–Meier method and comparisons were made using the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were employed to identify factors independently associated with five-year event-free survival (EFS).
[RESULTS] A total of 319 elderly patients with stage I-III breast cancer were included, with a 5-year overall EFS rate of 82.0%. Univariate analysis revealed significant associations between 5-year EFS and age, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 level, tumour size (T stage), lymph node status (N stage), and the administration of endocrine therapy (all < 0.05). Multivariate analysis revealed that age, PR status, T stage, N stage, and Ki-67 level were independent prognostic factors for 5-year EFS.
[CONCLUSIONS] The results of this study suggest that age, PR status, the Ki-67 index, tumour size, and lymph node metastasis can serve as independent predictors of the 5-year EFS rate in elderly patients with stage I-III breast cancer. Specifically, younger age (≤ 68 years), PR positivity, Ki-67 < 30%, and early T (T1-T2) and N (N0) stages are associated with a more favourable prognosis.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1186/s12957-026-04225-6.
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