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A brief review and case report of pheochromocytoma misdiagnosed as allergic vasculitis with bilateral lower extremity ulcers: a 24-year clinical course.

Frontiers in endocrinology 2026 Vol.17() p. 1773861

Li R, Cao Z, Wei H, Han J, Guo S, Zhang L, Lang X, Liu H, Cui H

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We report a 36-year-old male with pheochromocytoma presenting solely as progressive bilateral lower limb necrosis for 24 years, lacking classic symptoms (hypertension, headache, palpitations).

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BibTeX ↓ RIS ↓
APA Li R, Cao Z, et al. (2026). A brief review and case report of pheochromocytoma misdiagnosed as allergic vasculitis with bilateral lower extremity ulcers: a 24-year clinical course.. Frontiers in endocrinology, 17, 1773861. https://doi.org/10.3389/fendo.2026.1773861
MLA Li R, et al.. "A brief review and case report of pheochromocytoma misdiagnosed as allergic vasculitis with bilateral lower extremity ulcers: a 24-year clinical course.." Frontiers in endocrinology, vol. 17, 2026, pp. 1773861.
PMID 42039137
DOI 10.3389/fendo.2026.1773861

Abstract

We report a 36-year-old male with pheochromocytoma presenting solely as progressive bilateral lower limb necrosis for 24 years, lacking classic symptoms (hypertension, headache, palpitations). Misdiagnosed as allergic vasculitis, he developed atrophic scars and toe necrosis despite immunosuppression. Elevated catecholamines and a 4.8 cm adrenal mass confirmed the diagnosis. Postoperatively, ulcers healed, but toe amputation was needed. This case highlights diagnostic pitfalls of atypical pheochromocytoma, emphasizing dynamic biomarker monitoring for early detection.

MeSH Terms

Humans; Pheochromocytoma; Male; Adult; Adrenal Gland Neoplasms; Diagnostic Errors; Vasculitis; Lower Extremity; Hypersensitivity

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