The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis.
💡 한 문장 핵심
안드로겐성 탈모 치료의 유효성: 체계적 문헌고찰 및 메타분석.
메타분석
5/5 보강
TL;DR
This meta‐analysis strongly suggests that minoxidil, finasteride, and low‐level laser light therapy are effective for promoting hair growth in men with androgenetic alopecia and that minxidil is effective in women with androgensetic alipecia.
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· 인용됨 125
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연도별 인용 (2017–2026) · 합계 395
OpenAlex 토픽 ·
Hair Growth and Disorders
Ovarian function and disorders
Dermatologic Treatments and Research
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
안드로겐성 탈모(androgenetic alopecia, 남성형 탈모)에 대한 비수술적 치료법들이 위약(placebo) 대비 모발 밀도·굵기·성장(성장기:휴지기 비율, anagen:telogen ratio 증가로 정의)·환자 및 연구자 주관적 평가를 개선하는지 그 효능을 평가하고자 했습니다.
【방법】
2016년 12월까지 PubMed·Embase·Cochrane을 검색한 무작위대조시험(RCT)의 체계적 문헌고찰 및 메타분석입니다. 미국 예방서비스특별위원회(USPSTF) 기준으로 양호(good) 또는 보통(fair) 품질의 RCT만 포함했습니다.
【주요 결과】
5개 치료군(남성: 저출력 레이저 치료(LLLT), 5% 미녹시딜, 2% 미녹시딜, 1mg 피나스테리드 / 여성: 2% 미녹시딜) 모두에서 위약 대비 통계적으로 유의하게 우월했습니다(P < .00001). 다만 대부분 연구에서 이질성(heterogeneity)이 높다는 한계가 있습니다.
【임상적 시사점 (성형외과 의사 관점)】
미녹시딜·피나스테리드·저출력 레이저(LLLT)는 남성 탈모에서, 미녹시딜은 여성 탈모에서 근거가 확립된 1차 치료로 권고할 수 있습니다. 모발이식 상담 시 수술 단독보다 이들 약물·레이저 병행요법으로 이식모 생착과 기존모 유지를 함께 도모하는 것이 합리적이며, 다만 연구 간 이질성이 커 개별 환자의 치료 반응에는 편차가 있을 수 있음을 설명하는 것이 좋습니다.
[BACKGROUND] Androgenetic alopecia, or male pattern hair loss, is a hair loss disorder mediated by dihydrotestosterone, the potent form of testosterone. Currently, minoxidil and finasteride are Food and Drug Administration (FDA)-approved, and HairMax LaserComb, which is FDA-cleared, are the only treatments recognized by the FDA as treatments of androgenetic alopecia.
[OBJECTIVE] This systematic review and meta-analysis assesses the efficacy of nonsurgical treatments of androgenetic alopecia in comparison to placebo for improving hair density, thickness, growth (defined by an increased anagen:telogen ratio), or subjective global assessments done by patients and investigators.
[METHODS] A systematic review of randomized controlled trials was conducted. PubMed, Embase, and Cochrane were searched up to December 2016, with no lower limit on the year. We included only randomized controlled trials of good or fair quality based on the US Preventive Services Task Force quality assessment process.
[RESULTS] A meta-analysis was conducted separately for 5 groups of studies that tested the following hair loss treatments: low-level laser light therapy in men, 5% minoxidil in men, 2% minoxidil in men, 1 mg finasteride in men, and 2% minoxidil in women. All treatments were superior to placebo (P < .00001) in the 5 meta-analyses. Other treatments were not included because the appropriate data were lacking.
[LIMITATIONS] High heterogeneity in most studies.
[CONCLUSIONS] This meta-analysis strongly suggests that minoxidil, finasteride, and low-level laser light therapy are effective for promoting hair growth in men with androgenetic alopecia and that minoxidil is effective in women with androgenetic alopecia.
[OBJECTIVE] This systematic review and meta-analysis assesses the efficacy of nonsurgical treatments of androgenetic alopecia in comparison to placebo for improving hair density, thickness, growth (defined by an increased anagen:telogen ratio), or subjective global assessments done by patients and investigators.
[METHODS] A systematic review of randomized controlled trials was conducted. PubMed, Embase, and Cochrane were searched up to December 2016, with no lower limit on the year. We included only randomized controlled trials of good or fair quality based on the US Preventive Services Task Force quality assessment process.
[RESULTS] A meta-analysis was conducted separately for 5 groups of studies that tested the following hair loss treatments: low-level laser light therapy in men, 5% minoxidil in men, 2% minoxidil in men, 1 mg finasteride in men, and 2% minoxidil in women. All treatments were superior to placebo (P < .00001) in the 5 meta-analyses. Other treatments were not included because the appropriate data were lacking.
[LIMITATIONS] High heterogeneity in most studies.
[CONCLUSIONS] This meta-analysis strongly suggests that minoxidil, finasteride, and low-level laser light therapy are effective for promoting hair growth in men with androgenetic alopecia and that minoxidil is effective in women with androgenetic alopecia.
- p-value P < .00001
- 연구 설계 systematic review
【연구 목적】 안드로겐성 탈모(androgenetic alopecia, 남성형 탈모)에 대한 비수술적 치료법들이 위약(placebo) 대비 모발 밀도·굵기·성장(성장기:휴지기 비율, anagen:telogen ratio 증가로 정의)·환자 및 연구자 주관적 평가를 개선하는지 그 효능을 평가하고자 했습니다.
APA 7
Adil, A., & Godwin, M. (2017). The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis.. Journal of the American Academy of Dermatology, 77(1), 136-141.e5. https://doi.org/10.1016/j.jaad.2017.02.054
Vancouver
Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. Jour. Amer. Acad. Derm.. 2017;77(1):136-141.e5. doi:10.1016/j.jaad.2017.02.054
AMA 11
Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. Jour. Amer. Acad. Derm.. 2017;77(1):136-141.e5. doi:10.1016/j.jaad.2017.02.054
Chicago
Adil, A., and Godwin, M.. 2017. "The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis." Journal of the American Academy of Dermatology 77 (1): 136-141.e5. https://doi.org/10.1016/j.jaad.2017.02.054
MLA 9
Adil, A., and Godwin M. "The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis." Journal of the American Academy of Dermatology, vol. 77, no. 1, 2017, pp. 136-141.e5. doi:10.1016/j.jaad.2017.02.054.
PMID
28396101 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 약물 | minoxidil
|
미녹시딜 | dict | 6 | |
| 약물 | minoxidil
|
미녹시딜 | dict | 6 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 6 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 6 | |
| 약물 | finasteride
|
피나스테리드 | dict | 3 | |
| 약물 | finasteride
|
피나스테리드 | dict | 3 | |
| 질환 | male pattern hair loss
|
남성형 탈모 | dict | 1 | |
| 질환 | male pattern hair loss
|
남성형 탈모 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🤖 이 논문을 인용한 AI 인사이트 · 4건
📰 주간
안드로겐성 탈모 — 피나스테리드 핵심 근거
P: 안드로겐성 탈모 환자, 특히 안드로겐 과다(예: PCOS 관련) 병태생리를 가진 집단을 포함하며, 여성 및 장기 추적 대상은 근거가 부족한 영역 O: 모발 수, 모발 굵기, 환자 만족도 등이며, 평가 지표가 비표준화되어 비교가 제약됩니다. 장기 안전성도 추가 연구 영역으로 제시됩니다.
📰 주간
안드로겐성 탈모 — 메타분석상 minoxidil·finasteride 유효
P: 안드로겐성 탈모(AGA) 환자. 여성 AGA 및 비백인 인구에 대한 근거는 부족하여 일반화 가능성 검증이 추가로 필요합니다. O: 치료 유효성 지표로 모발 수·밀도·환자 만족도 등이 사용되나 평가지표가 비표준화되어 연구 간 이질성이 존재합니다.
📰 주간
탈모 치료 — minoxidil 1차 약물 입지 견고
P: 안드로겐성 탈모(AGA) 및 원형탈모(AA) 환자. AA의 경우 139개 SNP 등 유전·자가면역 인자의 이질성이 큰 집단을 포함합니다. O: 단위면적당 모발 수 등 표준화된 모발 효능 지표와 질적 종합 평가. 향후 순응도·경제성을 포함한 real-world 결과도 거론됩니다.
📰 주간
피나스테리드 — AGA 1차 치료 근거 확립
P: 안드로겐성 탈모(AGA) 환자가 중심이며, 내분비 영역의 다낭성 난소증후군(PCOS)·안드로겐 과다 집단을 포함합니다. 여성 AGA 집단은 근거 O: 모발 수·밀도 변화 등 유효성 지표와 장기 안전성(성기능·심리 영향), 순응도 및 경제성을 평가합니다.
이 논문은 위 AI 빅데이터 분석에 인용된 근거 논문입니다.
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
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