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Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil.

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The Journal of investigative dermatology 📖 저널 OA 65.1% 2021: 20/22 OA 2022: 11/14 OA 2023: 14/29 OA 2024: 15/36 OA 2025: 22/68 OA 2026: 32/69 OA 2021~2026 2001 Vol.117(6) p. 1594-600 피인용 16회 cited 125 OA RCR 2.34 Hair Growth and Disorders
TL;DR The results indicate that the effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via bothAdenosine A1 and A2 receptors, and that the expression of sulfonylurea receptor 2B in dermal papilla cells might play a role in the production of adenosines.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-10
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OpenAlex 토픽 · Hair Growth and Disorders Dermatologic Treatments and Research Skin Protection and Aging

Li M, Marubayashi A, Nakaya Y, Fukui K, Arase S

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The results indicate that the effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via bothAdenosine A1 and A2 receptors, and that the expression of sulfonylu

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APA Azusa Marubayashi, Yutaka Nakaya, et al. (2001). Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil.. The Journal of investigative dermatology, 117(6), 1594-600. https://doi.org/10.1046/j.0022-202x.2001.01570.x
MLA Azusa Marubayashi, et al.. "Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil.." The Journal of investigative dermatology, vol. 117, no. 6, 2001, pp. 1594-600.
PMID 11886528 ↗
DOI 10.1046/j.0022-202x.2001.01570.x

Abstract

The mechanism by which minoxidil, an adenosine-triphosphate-sensitive potassium channel opener, induces hypertrichosis remains to be elucidated. Minoxidil has been reported to stimulate the production of vascular endothelial growth factor, a possible promoter of hair growth, in cultured dermal papilla cells. The mechanism of production of vascular endothelial growth factor remains unclear, however. We hypothesize that adenosine serves as a mediator of vascular endothelial growth factor production. Minoxidil-induced increases in levels of intracellular Ca(2+) and vascular endothelial growth factor production in cultured dermal papilla cells were found to be inhibited by 8-sulfophenyl theophylline, a specific antagonist for adenosine receptors, suggesting that dermal papilla cells possess adenosine receptors and sulfonylurea receptors, the latter of which is a well-known target receptor for adenosine-triphosphate-sensitive potassium channel openers. The expression of sulfonylurea receptor 2B and of the adenosine A1, A2A, and A2B receptors was detected in dermal papilla cells by means of reverse transcription polymerase chain reaction analysis. In order to determine which of the adenosine receptor subtypes contribute to minoxidil-induced hair growth, the effects of subtype-specific antagonists for adenosine receptors were investigated. Significant inhibition in increase in intracellular calcium level by minoxidil or adenosine was observed as the result of pretreatment with 8-cyclopentyl-1,3-dipropylxanthine, an antagonist for adenosine A1 receptor, but not by 3,7-dimethyl-1-propargyl-xanthine, an antagonist for adenosine A2 receptor, whereas vascular endothelial growth factor production was blocked by both adenosine A1 and A2 receptor antagonists. These results indicate that the effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 and A2 receptors, and that the expression of sulfonylurea receptor 2B in dermal papilla cells might play a role in the production of adenosine.

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