Single-Session High-Dose Hyaluronidase for Managing Periorbital Hyaluronic Acid Filler Complications.
Abstract
[BACKGROUND] Periorbital complications from hyaluronic acid (HA) fillers are common due to the region's unique anatomy. Hyaluronidase is widely used for management, but dosing remains empirical with no standardized protocol. This study aimed to assess the safety and efficacy of a high-dose, single-session hyaluronidase approach for treating such complications.
[METHODS] A retrospective study was conducted on 54 patients presenting with periorbital HA-related complications between August 2020 and May 2024. Four main types of complications were identified: persistent edema, tear trough bulging, under-correction, and subcutaneous nodules. The average interval from the first HA injection to presentation was 25.8 months (range 1.5-72 months). Injection points were determined through visual inspection and palpation, marked at the most prominent areas, and spaced approximately 7-10 mm apart. A vertical bolus injection technique was used to administer 30-90 IU (0.1-0.3 mL) of hyaluronidase per point, totaling 150-600 IU per lower eyelid.
[RESULTS] The mean follow-up was 52.9 days (range 14-474 days). All patients responded successfully to one session of high-dose hyaluronidase. The mean dose per lower eyelid was 350.3 IU. No cases required retreatment. Nineteen patients (35.2%) achieved satisfactory outcomes without further intervention, while the remaining 35 (64.8%) underwent subsequent lower eyelid blepharoplasty.
[CONCLUSION] High-dose, single-session hyaluronidase injection is a safe, effective, and efficient approach for treating a broad range of HA-related periorbital complications, even in complex cases involving multiple previous treatments or long filler retention time.
[LEVEL OF EVIDENCE IV] This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
[METHODS] A retrospective study was conducted on 54 patients presenting with periorbital HA-related complications between August 2020 and May 2024. Four main types of complications were identified: persistent edema, tear trough bulging, under-correction, and subcutaneous nodules. The average interval from the first HA injection to presentation was 25.8 months (range 1.5-72 months). Injection points were determined through visual inspection and palpation, marked at the most prominent areas, and spaced approximately 7-10 mm apart. A vertical bolus injection technique was used to administer 30-90 IU (0.1-0.3 mL) of hyaluronidase per point, totaling 150-600 IU per lower eyelid.
[RESULTS] The mean follow-up was 52.9 days (range 14-474 days). All patients responded successfully to one session of high-dose hyaluronidase. The mean dose per lower eyelid was 350.3 IU. No cases required retreatment. Nineteen patients (35.2%) achieved satisfactory outcomes without further intervention, while the remaining 35 (64.8%) underwent subsequent lower eyelid blepharoplasty.
[CONCLUSION] High-dose, single-session hyaluronidase injection is a safe, effective, and efficient approach for treating a broad range of HA-related periorbital complications, even in complex cases involving multiple previous treatments or long filler retention time.
[LEVEL OF EVIDENCE IV] This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 재료 | ha
|
히알루론산 | dict | 4 | |
| 해부 | lower eyelid
|
눈꺼풀 | dict | 3 | |
| 재료 | hyaluronic acid
|
히알루론산 | dict | 2 | |
| 시술 | blepharoplasty
|
안검성형술 | dict | 1 | |
| 시술 | hyaluronic acid filler
|
필러 주입술 | dict | 1 | |
| 시술 | filler
|
필러 주입술 | dict | 1 | |
| 해부 | periorbital
|
scispacy | 1 | ||
| 해부 | tear
|
scispacy | 1 | ||
| 해부 | subcutaneous nodules.
|
scispacy | 1 | ||
| 해부 | eyelid
|
scispacy | 1 | ||
| 해부 | subcutaneous
|
피하조직 | dict | 1 | |
| 합병증 | edema
|
scispacy | 1 | ||
| 합병증 | eyelid
|
scispacy | 1 | ||
| 약물 | high-dose
|
scispacy | 1 | ||
| 약물 | [BACKGROUND] Periorbital complications
|
scispacy | 1 | ||
| 약물 | high-dose hyaluronidase
|
scispacy | 1 | ||
| 질환 | edema
|
C0013604
Edema
|
scispacy | 1 | |
| 질환 | under-correction
|
scispacy | 1 | ||
| 질환 | Periorbital Hyaluronic Acid
|
scispacy | 1 | ||
| 기타 | Hyaluronidase
|
scispacy | 1 | ||
| 기타 | patients
|
scispacy | 1 |
MeSH Terms
Humans; Hyaluronoglucosaminidase; Retrospective Studies; Hyaluronic Acid; Female; Dermal Fillers; Middle Aged; Adult; Male; Treatment Outcome; Cosmetic Techniques; Aged; Follow-Up Studies; Skin Aging; Eyelids; Dose-Response Relationship, Drug
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