Wound healing and skin regeneration.
💡 한 문장 핵심
상처 치유와 피부 재생.
5/5 보강
TL;DR
This article will focus on the contribution of skin appendages to wound healing and, conversely, skin appendage regeneration following injuries.
📑 코퍼스 인용 관계
· 인용됨 13 · 인용함 67
→ 이 논문이 인용한 논문 (4) ▾
- Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature · 2013
- Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (New York, N.Y.) · 2010
- Molecular mechanisms regulating hair follicle development. The Journal of investigative dermatology · 2002
- Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell · 2001
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연도별 인용 (2012–2026) · 합계 656
OpenAlex 토픽 ·
Wound Healing and Treatments
Hair Growth and Disorders
Dermatologic Treatments and Research
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
성인 포유류의 상처 치유는 모낭(hair follicle)·피지선 등 피부 부속기 없이 흉터로 마무리되는데, 본 종설은 피부 부속기가 상처 치유에 기여하는 역할과, 반대로 손상 후 피부 부속기가 재생되는 기전을 정리하는 것을 목적으로 합니다.
【방법】
태아 피부의 무흉터 치유(scarless healing)와 대형 창상 후 성체 피부에서 나타나는 부속기 재생 사례를 다룬 기존 연구들을 고찰한 리뷰(종설) 형식으로, 이들 모델이 제시한 세포·분자 수준의 기전을 종합 분석했습니다.
【주요 결과】
태아 피부는 흉터 없이 치유되며, 충분히 큰 창상에서는 성체 피부에서도 모낭 등 부속기의 신생 재생(de novo regeneration)이 관찰됩니다. 즉 피부 부속기와 상처 치유는 상호작용하며, 부속기가 치유 과정의 세포 공급원이자 재생의 결과물로 작용합니다.
【임상적 시사점 (성형외과 의사 관점)】
흉터 없는 치유와 모낭 재생의 분자 기전은 향후 흉터 최소화·모발 재생 치료의 표적이 될 수 있습니다. 창상 크기가 부속기 재생을 유도하는 임계점으로 작용한다는 점은 반흔 성형·재건 시 창상 관리 전략에 시사점을 주며, 다만 본 논문은 기초 종설로 직접적 임상 프로토콜이 아닌 기전 이해 자료로 활용하시기 바랍니다.
The skin is a complex organ consisting of the epidermis, dermis, and skin appendages, including the hair follicle and sebaceous gland. Wound healing in adult mammals results in scar formation without any skin appendages. Studies have reported remarkable examples of scarless healing in fetal skin and appendage regeneration in adult skin following the infliction of large wounds. The models used in these studies have offered a new platform for investigations of the cellular and molecular mechanisms underlying wound healing and skin regeneration in mammals. In this article, we will focus on the contribution of skin appendages to wound healing and, conversely, skin appendage regeneration following injuries.
【연구 목적】 성인 포유류의 상처 치유는 모낭(hair follicle)·피지선 등 피부 부속기 없이 흉터로 마무리되는데, 본 종설은 피부 부속기가 상처 치유에 기여하는 역할과, 반대로 손상 후 피부 부속기가 재생되는 기전을 정리하는 것을 목적으로 합니다.
APA 7
Takeo, M., Lee, W., & Ito, M. (2015). Wound healing and skin regeneration.. Cold Spring Harbor perspectives in medicine, 5(1), a023267. https://doi.org/10.1101/cshperspect.a023267
Vancouver
Takeo M, Lee W, Ito M. Wound healing and skin regeneration. Cold Spri. Harb. pers. medi.. 2015;5(1):a023267. doi:10.1101/cshperspect.a023267
AMA 11
Takeo M, Lee W, Ito M. Wound healing and skin regeneration. Cold Spri. Harb. pers. medi.. 2015;5(1):a023267. doi:10.1101/cshperspect.a023267
Chicago
Takeo, M., Lee, W., and Ito, M.. 2015. "Wound healing and skin regeneration." Cold Spring Harbor perspectives in medicine 5 (1): a023267. https://doi.org/10.1101/cshperspect.a023267
MLA 9
Takeo, M., et al. "Wound healing and skin regeneration." Cold Spring Harbor perspectives in medicine, vol. 5, no. 1, 2015, pp. a023267. doi:10.1101/cshperspect.a023267.
PMID
25561722 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🤖 이 논문을 인용한 AI 인사이트 · 1건
이 논문은 위 AI 빅데이터 분석에 인용된 근거 논문입니다.
인용 관계
그래프 OA 노드: 11/12 (92%)
· 참조 3편 · 후속 8편
이 논문이 참조한 문헌 34
- Molecular mechanisms regulating hair follicle development.
- Morphogenesis and renewal of hair follicles from adult multipotent stem cells.
- Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
- Distinct fibroblast lineages determine dermal architecture in skin development and repair.
외부 PMID 30건 (DB 미수집)
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- PMID 10771470 ↗
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- PMID 16808805 ↗
- PMID 17255473 ↗
- PMID 17507982 ↗
- PMID 18037901 ↗
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- PMID 21206086 ↗
- PMID 21253544 ↗
이 논문을 인용한 후속 연구 13
- Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and …
- Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound h…
- Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3.
- Biofabrication of Human Skin with Its Appendages.
- Materials-based hair follicle engineering: Basic components and recent advances.
- Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Prolife…
- Dermal β-Catenin Is Required for Hedgehog-Driven Hair Follicle Neogenesis.
- Peptide Cy accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor.
- Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair gr…
- The development of hair follicles and nail.
- The regenerative wound healing effects and molecular mechanism of Isaria cicadae Miquel rice ferment…
- Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration.
- Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses.
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