Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis.
💡 한 문장 핵심
모낭 노화는 COL17A1 단백질분해를 통한 줄기세포의 표피경유 소실에 의해 진행된다.
5/5 보강
TL;DR
The fate analysis of HFSCs during aging revealed that organ aging is primed by the sustained DNA damage response against DNA damage that accumulates in renewing stem cells during aging.
📑 코퍼스 인용 관계
· 인용됨 77
📑 인용한 논문 (6) ▾
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연도별 인용 (2016–2026) · 합계 386
OpenAlex 토픽 ·
Hair Growth and Disorders
melanin and skin pigmentation
Skin Protection and Aging
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
모낭(hair follicle) 노화와 그로 인한 모발 가늘어짐·탈모의 분자적 기전을 규명하고자, 모낭줄기세포(hair follicle stem cell, HFSC)가 노화·소실되는 과정과 그 핵심 조절인자를 밝히는 것이 목적이다.
【방법】
야생형 마우스와 사람 조직을 대상으로 HFSC의 생체 내 운명추적(in vivo fate analysis)을 시행했고, Col17a1 결손 모델과 COL17A1 강제 발현 모델을 이용해 노화 표현형의 재현 및 차단 여부를 검증했다.
【주요 결과】
HFSC의 DNA 손상 반응이 줄기세포 유지에 필수적인 제17형 콜라겐(COL17A1/BP180)의 분해를 유발하고, 노화된 HFSC가 표피로 분화·탈락하면서 모낭이 단계적으로 미세화(miniaturization)되어 탈모에 이른다. COL17A1을 유지시키면 이 노화 과정이 차단되었다.
【임상적 시사점 (성형외과 의사 관점)】
남성형·노화성 탈모의 핵심 표적으로 COL17A1 유지·보호가 부상하므로, 향후 모발이식이나 약물·재생치료에서 줄기세포 노화 억제(COL17A1 안정화) 전략이 보조 치료의 새 방향이 될 수 있다. 다만 본 연구는 동물·기초 단계이므로 현 임상 적용보다는 향후 항노화 모발치료제 개발 동향으로 참고하는 것이 적절하다.
Hair thinning and loss are prominent aging phenotypes but have an unknown mechanism. We show that hair follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans. In vivo fate analysis of HFSCs revealed that the DNA damage response in HFSCs causes proteolysis of type XVII collagen (COL17A1/BP180), a critical molecule for HFSC maintenance, to trigger HFSC aging, characterized by the loss of stemness signatures and by epidermal commitment. Aged HFSCs are cyclically eliminated from the skin through terminal epidermal differentiation, thereby causing hair follicle miniaturization. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in HFSCs, demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.
【연구 목적】 모낭(hair follicle) 노화와 그로 인한 모발 가늘어짐·탈모의 분자적 기전을 규명하고자, 모낭줄기세포(hair follicle stem cell, HFSC)가 노화·소실되는 과정과 그 핵심 조절인자를 밝히는 것이 목적이다.
APA 7
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016). Hair follicle aging is driven by transepidermal elimination of stem cells via col17a1 proteolysis.. Science (New York, N.Y.), 351(6273), aad4395. https://doi.org/10.1126/science.aad4395
Vancouver
Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science (New York, N.Y.). 2016;351(6273):aad4395. doi:10.1126/science.aad4395
AMA 11
Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science (New York, N.Y.). 2016;351(6273):aad4395. doi:10.1126/science.aad4395
Chicago
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., and Nishimura, E. K.. 2016. "Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis." Science (New York, N.Y.) 351 (6273): aad4395. https://doi.org/10.1126/science.aad4395
MLA 9
Matsumura, H., et al. "Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis." Science (New York, N.Y.), vol. 351, no. 6273, 2016, pp. aad4395. doi:10.1126/science.aad4395.
PMID
26912707 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 3 | |
| 해부 | hair follicle
|
모낭 | dict | 3 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
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- Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- 피나스테리드가 전립선암 발생에 미치는 영향.
- COVID-19의 50가지 이상의 장기 후유증: 체계적 문헌고찰 및 메타분석.
- 양성 전립선 비대증의 임상적 진행에 대한 doxazosin, finasteride 및 병용 요법의 장기 효과.
- 양성 전립선 비대증 환자에서 finasteride의 효과. The Finasteride Study Group.
- 양성 전립선 비대증 남성에서 급성 요폐의 위험과 수술적 치료 필요성에 대한 finasteride의 효과. Finasteride Long-Term Efficacy and Safety Study Group.
- 원형 탈모.
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