Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia.
💡 한 문장 핵심
안드로겐성 탈모 치료에서 혈소판 풍부 혈장(PRP)의 효능을 평가하기 위한 무작위 위약 대조, 이중맹검, 반두피 연구.
무작위 임상시험
5/5 보강
TL;DR
Application of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA and a correlation between anagen hairs and patients >40 years and beginning of AGA was found.
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
25 patients with AGA.
I · Intervention 중재 / 시술
a total of 3 treatments of PRP, 1 month apart
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
For the first time, the authors found a correlation between anagen hairs and patients >40 years and beginning of AGA ≥25 years old (p < .05) and hair density and male sex, age ≤40 years, positive family history of AGA and >10 years of duration of the disease (p < 0.05). [CONCLUSION] Application of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA.
📑 코퍼스 인용 관계
· 인용됨 39
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연도별 인용 (2016–2026) · 합계 229
OpenAlex 토픽 ·
Hair Growth and Disorders
Facial Rejuvenation and Surgery Techniques
Periodontal Regeneration and Treatments
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
안드로겐성 탈모(androgenetic alopecia, AGA) 치료에 있어 자가혈 혈소판풍부혈장(platelet-rich plasma, PRP) 주입의 유효성을 평가하기 위한 연구입니다.
【방법】
AGA 환자 25명을 대상으로 한 무작위·이중맹검·위약대조 반두피(half-head) 비교 연구입니다. 한쪽 두피에는 PRP를, 반대쪽에는 위약을 주입했으며, 각 환자는 1개월 간격으로 총 3회 PRP 치료를 받았습니다.
【주요 결과】
첫 치료 6개월 후, 성장기 모발(anagen) 수, 모발 밀도, 종모(terminal hair) 밀도가 기저치 대비 유의하게 증가했고(p<.05), 위약 측과 비교해도 모발 밀도가 더 높았습니다(p<.05). 또한 연령·성별·가족력·이환 기간 등과 치료 반응 간 상관관계가 처음으로 확인되었습니다(남성, 40세 이하, AGA 가족력 양성, 10년 이상 이환 시 밀도 개선이 두드러짐).
【임상적 시사점 (성형외과 의사 관점)】
PRP는 AGA의 단독 치료보다는 기존 약물(미녹시딜, 피나스테리드)이나 모발이식과 병행하는 보조요법(adjuvant therapy)으로 고려할 수 있습니다. 다만 표본 수가 25명으로 적고 PRP 제조·주입 프로토콜이 표준화되어 있지 않으므로, 환자 상담 시 효과의 개인차와 반복 시술 필요성을 함께 설명하는 것이 바람직합니다.
[BACKGROUND] Platelet-rich plasma (PRP) was identified as having a beneficial effect in alopecia and has been postulated as a new therapy for androgenetic alopecia (AGA).
[OBJECTIVE] To assess the efficacy of PRP for the treatment of AGA.
[MATERIALS AND METHODS] This was a randomized, placebo-controlled, double-blind study in 25 patients with AGA. Platelet-rich plasma was injected in half-head and the other half-head with placebo. Each patient received a total of 3 treatments of PRP, 1 month apart.
[RESULTS] Six months after the first treatment with PRP, significant differences were seen in mean anagen hairs (67.6 ± 13.1), telogen hairs (32.4 ± 13.1), hair density (179.9 ± 62.7), and terminal hair density (165.8 ± 56.8) when compared with baseline (p < .05). Platelet-rich plasma was also found to increase hair density when comparing with the control side (p < .05). For the first time, the authors found a correlation between anagen hairs and patients >40 years and beginning of AGA ≥25 years old (p < .05) and hair density and male sex, age ≤40 years, positive family history of AGA and >10 years of duration of the disease (p < 0.05).
[CONCLUSION] Application of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA.
[OBJECTIVE] To assess the efficacy of PRP for the treatment of AGA.
[MATERIALS AND METHODS] This was a randomized, placebo-controlled, double-blind study in 25 patients with AGA. Platelet-rich plasma was injected in half-head and the other half-head with placebo. Each patient received a total of 3 treatments of PRP, 1 month apart.
[RESULTS] Six months after the first treatment with PRP, significant differences were seen in mean anagen hairs (67.6 ± 13.1), telogen hairs (32.4 ± 13.1), hair density (179.9 ± 62.7), and terminal hair density (165.8 ± 56.8) when compared with baseline (p < .05). Platelet-rich plasma was also found to increase hair density when comparing with the control side (p < .05). For the first time, the authors found a correlation between anagen hairs and patients >40 years and beginning of AGA ≥25 years old (p < .05) and hair density and male sex, age ≤40 years, positive family history of AGA and >10 years of duration of the disease (p < 0.05).
[CONCLUSION] Application of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA.
- p-value p < .05
【연구 목적】 안드로겐성 탈모(androgenetic alopecia, AGA) 치료에 있어 자가혈 혈소판풍부혈장(platelet-rich plasma, PRP) 주입의 유효성을 평가하기 위한 연구입니다.
APA 7
Alves, R., & Grimalt, R. (2016). Randomized placebo-controlled, double-blind, half-head study to assess the efficacy of platelet-rich plasma on the treatment of androgenetic alopecia.. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 42(4), 491-7. https://doi.org/10.1097/DSS.0000000000000665
Vancouver
Alves R, Grimalt R. Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia. Derm. surg. : offi. publ. Amer. Soci. Derm. Surg. [et al.]. 2016;42(4):491-7. doi:10.1097/DSS.0000000000000665
AMA 11
Alves R, Grimalt R. Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia. Derm. surg. : offi. publ. Amer. Soci. Derm. Surg. [et al.]. 2016;42(4):491-7. doi:10.1097/DSS.0000000000000665
Chicago
Alves, R., and Grimalt, R.. 2016. "Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia." Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 42 (4): 491-7. https://doi.org/10.1097/DSS.0000000000000665
MLA 9
Alves, R., and Grimalt R. "Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia." Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], vol. 42, no. 4, 2016, pp. 491-7. doi:10.1097/DSS.0000000000000665.
PMID
27035501 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
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- Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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