Chronic hepatitis b coinfection and survival in pediatric T-ALL: A propensity-matched analysis.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: HBV-negative, the CHB-AE cohort had markedly inferior 5-year event-free survival (13
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The study identifies HBV coinfection as an independent adverse prognostic factor in pediatric T-ALL. These findings highlight the urgent need for prospective studies to investigate the underlying mechanisms and to develop novel therapeutic strategies for this high-risk patient subgroup.
In this retrospective study of 251 pediatric patients with T cell acute lymphoblastic leukemia (T-ALL), chronic hepatitis B virus (HBV) infection with acute exacerbation (CHB-AE) was associated with s
APA
Zhang Y, Wu R, et al. (2026). Chronic hepatitis b coinfection and survival in pediatric T-ALL: A propensity-matched analysis.. iScience, 29(1), 114319. https://doi.org/10.1016/j.isci.2025.114319
MLA
Zhang Y, et al.. "Chronic hepatitis b coinfection and survival in pediatric T-ALL: A propensity-matched analysis.." iScience, vol. 29, no. 1, 2026, pp. 114319.
PMID
41531730 ↗
Abstract 한글 요약
In this retrospective study of 251 pediatric patients with T cell acute lymphoblastic leukemia (T-ALL), chronic hepatitis B virus (HBV) infection with acute exacerbation (CHB-AE) was associated with significantly poorer outcomes. Compared to patients with HBV-negative, the CHB-AE cohort had markedly inferior 5-year event-free survival (13.24% vs. 80.58%) and overall survival. After using propensity score matching to balance baseline characteristics, the difference in event-free survival remained significant. Subgroup analyses consistently showed worse outcomes for patients with CHB-AE, particularly those with high-risk features such as elevated leukocyte counts or central nervous system involvement. The study identifies HBV coinfection as an independent adverse prognostic factor in pediatric T-ALL. These findings highlight the urgent need for prospective studies to investigate the underlying mechanisms and to develop novel therapeutic strategies for this high-risk patient subgroup.
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