Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
multiplex immunostaining, RNA sequencing, glycosylation profiling, and computational analysis
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Acting as a glycan rheostat, GNAS elevates LacdiNAcs at the expense of pro-tumorigenic acidic Lewis epitopes, inhibiting cancer cell invasion and disease progression. LacdiNAcs and 3'-sulfo-Le are mutually exclusive and may serve as markers to risk stratify IPMN patients for surgery.
Intraductal papillary mucinous neoplasms (IPMNs) are cystic lesions and bona fide precursors of pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors.
APA
Quoc-Huy Trinh V, Ankenbauer KE, et al. (2025). Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia.. Cell reports, 44(12), 116684. https://doi.org/10.1016/j.celrep.2025.116684
MLA
Quoc-Huy Trinh V, et al.. "Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia.." Cell reports, vol. 44, no. 12, 2025, pp. 116684.
PMID
41370125 ↗
Abstract 한글 요약
Intraductal papillary mucinous neoplasms (IPMNs) are cystic lesions and bona fide precursors of pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Although ∼90% of IPMNs are detected before PDAC forms, markers distinguishing benign from malignant disease are lacking, resulting in an abundance of unnecessary, invasive surgeries. Recent studies show that pancreatic precancer assumes a pyloric phenotype. To identify the regulators of this plasticity, cell lines, organoids, tumors from mouse models of IPMNs, and patient samples underwent multiplex immunostaining, RNA sequencing, glycosylation profiling, and computational analysis. These data revealed that GNAS drives an indolent phenotype in IPMNs by amplifying a differentiated, pyloric phenotype through SPDEF/CREB3L1, which is characterized by distinct glycans. Acting as a glycan rheostat, GNAS elevates LacdiNAcs at the expense of pro-tumorigenic acidic Lewis epitopes, inhibiting cancer cell invasion and disease progression. LacdiNAcs and 3'-sulfo-Le are mutually exclusive and may serve as markers to risk stratify IPMN patients for surgery.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Animals
- GTP-Binding Protein alpha Subunits
- Gs
- Mice
- Polysaccharides
- Chromogranins
- Pancreatic Intraductal Neoplasms
- Metaplasia
- Mutation
- Carcinoma
- Pancreatic Ductal
- Cell Line
- Tumor
- Pancreatic Neoplasms
- Adenocarcinoma
- Mucinous
- CP: cancer
- CREB3L1
- GNAS
- SPDEF
- glycans
- intraductal papillary mucinous neoplasm
- pancreatic cancer
… 외 1개
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