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Pituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Administration for Prostate Cancer.

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IJU case reports 📖 저널 OA 100% 2022: 1/1 OA 2025: 9/9 OA 2026: 25/25 OA 2022~2026 2026 Vol.9(2) p. e70159
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Fujimura M, Shimizu T, Sakamoto S, Sato H, Suzuki H, Mikami K

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[INTRODUCTION] Pituitary apoplexy represents an uncommon endocrine emergency with potentially life-threatening consequences.

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APA Fujimura M, Shimizu T, et al. (2026). Pituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Administration for Prostate Cancer.. IJU case reports, 9(2), e70159. https://doi.org/10.1002/iju5.70159
MLA Fujimura M, et al.. "Pituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Administration for Prostate Cancer.." IJU case reports, vol. 9, no. 2, 2026, pp. e70159.
PMID 41767037 ↗
DOI 10.1002/iju5.70159

Abstract

[INTRODUCTION] Pituitary apoplexy represents an uncommon endocrine emergency with potentially life-threatening consequences. Gonadotropin-releasing hormone agonist used for prostate cancer has the potential to induce pituitary apoplexy, particularly in the setting of a preexisting pituitary adenoma.

[CASE PRESENTATION] A 76-year-old male with prostate cancer initially chose active surveillance; however, prostate-specific antigen (PSA) elevation required hormonal therapy 5 years later. A pancreatic islet tumor had been previously identified; however, its details were unavailable. He was presented to the emergency department 24 h after receiving the first gonadotropin-releasing hormone agonist injection. He showed severe headache, general fatigue, diplopia, and ptosis of the right eye. Brain MRI revealed a right deviated suprasellar pituitary adenoma with hemorrhagic infarction. He was conservatively treated with high-dose steroids; symptoms improved within 1 week.

[CONCLUSION] Clinicians should be aware of the association of pituitary apoplexy with the use of gonadotropin-releasing hormone agonist and should ask about the patient's past history of multiple endocrine neoplasia (MEN).

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