Timing and clinical significance of chemotherapy in patients with resected gastric adenocarcinoma: a population-based cohort study.
코호트
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
4914 patients, 38.
I · Intervention 중재 / 시술
gastrectomy were extracted from Surveillance, Epidemiology, and End Results database
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
However, older individuals and those with well-differentiated tumors could be considered exempt from further AC after receiving NAC and gastrectomy. Further research is needed to validate these findings and optimize GC management.
[BACKGROUND] This study was to assess the impact of chemotherapy sequence on the prognosis of patients with gastric cancer (GC) undergoing gastrectomy and identify optimal chemotherapy timing along wi
APA
Zhang D, Yang Q, et al. (2025). Timing and clinical significance of chemotherapy in patients with resected gastric adenocarcinoma: a population-based cohort study.. The oncologist, 30(7). https://doi.org/10.1093/oncolo/oyaf179
MLA
Zhang D, et al.. "Timing and clinical significance of chemotherapy in patients with resected gastric adenocarcinoma: a population-based cohort study.." The oncologist, vol. 30, no. 7, 2025.
PMID
40592733 ↗
Abstract 한글 요약
[BACKGROUND] This study was to assess the impact of chemotherapy sequence on the prognosis of patients with gastric cancer (GC) undergoing gastrectomy and identify optimal chemotherapy timing along with potential candidates.
[PATIENTS AND METHODS] Data on patients who underwent gastrectomy were extracted from Surveillance, Epidemiology, and End Results database. Prognostic factors for overall survival (OS) were assessed using Kaplan-Meier and Cox regression analyses. Treatment strategies were categorized into neoadjuvant chemotherapy (NAC), adjuvant chemotherapy (AC), and perioperative chemotherapy (PC), with subsequent analyses of clinical outcomes. Stable inverse probability of treatment weighting (sIPTW) and subgroup analyses were conducted to evaluate the significance of chemotherapy timing.
[RESULTS] Among 4914 patients, 38.4% received NAC, 45% received AC, and 16.6% received PC. The 5-year OS rates for the entire cohort were 41.2%. Although no significant differences were observed between NAC and AC, PC exhibited a substantial improvement in OS compared to both. Multivariate analysis highlighted chemotherapy timing as a prognostic factor for OS. Even after sIPTW, PC still demonstrated significantly longer OS compared to NAC and AC, and this trend persisted across almost all subgroups. Even after patients underwent NAC and gastrectomy, AC remained essential. Notably, potential candidates exempt from AC were identified, including patients aged ≥65 years and those with tumor grades I-II.
[CONCLUSIONS] Chemotherapy timing was an independent prognostic factor for resected GC. PC presented as a promising strategy, displaying superior OS compared to both NAC and AC. However, older individuals and those with well-differentiated tumors could be considered exempt from further AC after receiving NAC and gastrectomy. Further research is needed to validate these findings and optimize GC management.
[PATIENTS AND METHODS] Data on patients who underwent gastrectomy were extracted from Surveillance, Epidemiology, and End Results database. Prognostic factors for overall survival (OS) were assessed using Kaplan-Meier and Cox regression analyses. Treatment strategies were categorized into neoadjuvant chemotherapy (NAC), adjuvant chemotherapy (AC), and perioperative chemotherapy (PC), with subsequent analyses of clinical outcomes. Stable inverse probability of treatment weighting (sIPTW) and subgroup analyses were conducted to evaluate the significance of chemotherapy timing.
[RESULTS] Among 4914 patients, 38.4% received NAC, 45% received AC, and 16.6% received PC. The 5-year OS rates for the entire cohort were 41.2%. Although no significant differences were observed between NAC and AC, PC exhibited a substantial improvement in OS compared to both. Multivariate analysis highlighted chemotherapy timing as a prognostic factor for OS. Even after sIPTW, PC still demonstrated significantly longer OS compared to NAC and AC, and this trend persisted across almost all subgroups. Even after patients underwent NAC and gastrectomy, AC remained essential. Notably, potential candidates exempt from AC were identified, including patients aged ≥65 years and those with tumor grades I-II.
[CONCLUSIONS] Chemotherapy timing was an independent prognostic factor for resected GC. PC presented as a promising strategy, displaying superior OS compared to both NAC and AC. However, older individuals and those with well-differentiated tumors could be considered exempt from further AC after receiving NAC and gastrectomy. Further research is needed to validate these findings and optimize GC management.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Stomach Neoplasms
- Male
- Female
- Middle Aged
- Aged
- Adenocarcinoma
- Gastrectomy
- Chemotherapy
- Adjuvant
- Prognosis
- Neoadjuvant Therapy
- Cohort Studies
- Adult
- SEER Program
- 80 and over
- Clinical Relevance
- adjuvant chemotherapy
- and end results database
- epidemiology
- gastric cancer
- neoadjuvant chemotherapy
- perioperative chemotherapy
- surveillance
… 외 1개
같은 제1저자의 인용 많은 논문 (5)
- LedX: A novel blood-based early lung cancer detection approach with exceptional accuracy and robustness.
- Locoregional control of downstaged breast-conserving surgery after neoadjuvant chemotherapy: A propensity-matched study in Chinese patients.
- Comments on "Clonal hematopoiesis of indeterminate potential and the risk of breast cancer: a UK Biobank cohort study".
- Adjuvant Chemotherapy in Breast Cancer after Neoadjuvant Therapy: Essential or Optional?
- γ-terpinene inhibits the progression of hepatocellular carcinoma by regulating the PTEN/PI3K/Akt signaling pathway mediated glycolysis.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.