Longitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
5925 patients undergoing curative resection for stage I-III non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and gastric cancer (GC) were retrospectively included.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Furthermore, stratified analyses confirmed statistically significant associations of ChE dynamic changes with prognosis across all histological subtypes. [CONCLUSIONS] A routine follow-up measurement of postoperative ChE was recommended to improve individualized management of cancer patients.
[BACKGROUND] Existing literature on serum cholinesterase (ChE) in cancer prognosis have predominantly evaluated preoperative levels, ignoring serial ChE measurements during postoperative follow-up.
- 95% CI 1.14 to 1.99
- HR 1.50
APA
Li C, Li Y, et al. (2025). Longitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer.. Communications medicine, 5(1), 391. https://doi.org/10.1038/s43856-025-01133-w
MLA
Li C, et al.. "Longitudinal evaluation of serum cholinesterase benefits prognosis surveillance of common types of human cancer.." Communications medicine, vol. 5, no. 1, 2025, pp. 391.
PMID
40983674 ↗
Abstract 한글 요약
[BACKGROUND] Existing literature on serum cholinesterase (ChE) in cancer prognosis have predominantly evaluated preoperative levels, ignoring serial ChE measurements during postoperative follow-up.
[METHODS] 5925 patients undergoing curative resection for stage I-III non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and gastric cancer (GC) were retrospectively included. Patients were divided into persistently normal, normalized, lowered and persistently low perioperative ChE patterns, as well as longitudinal ChE trajectories identified by the latent class growth mixed model (LCGMM). The associations of ChE dynamic changes with overall survival (OS) and recurrence-free survival (RFS) were evaluated.
[RESULTS] Postoperative ChE emerged as an independent prognostic factor, event after accounting for preoperative levels. Perioperative ChE stratification revealed divergent survival outcomes: the persistently normal group (82.5%) demonstrated 8.6% higher 5-year OS rate than the lowered group (73.9%), while the normalized group (73.3%) had 13.9% higher 5-year OS rate than the persistently low group (59.4%). LCGMM identified three distinct longitudinal trajectories: slow-rising (5-year OS rate: 79.7%; reference group), rising-decreasing (5-year OS rate: 64.8%; adjusted HR: 1.50, 95% CI: 1.14 to 1.99) and decreasing-rising (5-year OS rate: 58.1%; adjusted HR: 2.33, 95% CI: 1.69 to 3.22). Consistent results were observed for RFS as well. Furthermore, stratified analyses confirmed statistically significant associations of ChE dynamic changes with prognosis across all histological subtypes.
[CONCLUSIONS] A routine follow-up measurement of postoperative ChE was recommended to improve individualized management of cancer patients.
[METHODS] 5925 patients undergoing curative resection for stage I-III non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and gastric cancer (GC) were retrospectively included. Patients were divided into persistently normal, normalized, lowered and persistently low perioperative ChE patterns, as well as longitudinal ChE trajectories identified by the latent class growth mixed model (LCGMM). The associations of ChE dynamic changes with overall survival (OS) and recurrence-free survival (RFS) were evaluated.
[RESULTS] Postoperative ChE emerged as an independent prognostic factor, event after accounting for preoperative levels. Perioperative ChE stratification revealed divergent survival outcomes: the persistently normal group (82.5%) demonstrated 8.6% higher 5-year OS rate than the lowered group (73.9%), while the normalized group (73.3%) had 13.9% higher 5-year OS rate than the persistently low group (59.4%). LCGMM identified three distinct longitudinal trajectories: slow-rising (5-year OS rate: 79.7%; reference group), rising-decreasing (5-year OS rate: 64.8%; adjusted HR: 1.50, 95% CI: 1.14 to 1.99) and decreasing-rising (5-year OS rate: 58.1%; adjusted HR: 2.33, 95% CI: 1.69 to 3.22). Consistent results were observed for RFS as well. Furthermore, stratified analyses confirmed statistically significant associations of ChE dynamic changes with prognosis across all histological subtypes.
[CONCLUSIONS] A routine follow-up measurement of postoperative ChE was recommended to improve individualized management of cancer patients.
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