Trends and incidence of stomach cancer in middle-aged and elderly populations: a global burden of disease analysis.
1/5 보강
[BACKGROUND] Stomach cancer remains a leading cause of cancer deaths in middle-aged and elderly populations.
APA
Tang Y, Wang D, et al. (2025). Trends and incidence of stomach cancer in middle-aged and elderly populations: a global burden of disease analysis.. Journal of gastrointestinal oncology, 16(5), 1890-1901. https://doi.org/10.21037/jgo-2025-151
MLA
Tang Y, et al.. "Trends and incidence of stomach cancer in middle-aged and elderly populations: a global burden of disease analysis.." Journal of gastrointestinal oncology, vol. 16, no. 5, 2025, pp. 1890-1901.
PMID
41220727 ↗
Abstract 한글 요약
[BACKGROUND] Stomach cancer remains a leading cause of cancer deaths in middle-aged and elderly populations. This study aimed to examine global trends in incidence among individuals aged 50-74 years and to explore disparities by age, sex, and region using Global Burden of Disease (GBD) data.
[METHODS] Data on stomach cancer incidence were extracted from the GBD 2021 database. We analyzed incidence rates for individuals aged 50-74 years, stratified by age, sex, and geographic region. Trends from 1990 to 2021 were evaluated using the Estimated Annual Percentage Change (EAPC) based on log-linear regression models. Pearson correlation was used to examine associations between incidence trends and the Socio-Demographic Index (SDI). Data standardization was based on the GBD world standard population.
[RESULTS] From 1990 to 2021, the number of stomach cancer cases among individuals aged 50-74 years increased by 17.32%, while the incidence rates declined from 80.67 to 44.18 per 100,000 (EAPC: -2.15). Males consistently exhibited higher incidence rates than females. The decline was less pronounced in older age groups, particularly those aged 65-74 years, where the number of cases continued to rise, reflecting population aging and cumulative risk exposure. High-SDI regions experienced the largest reductions (e.g., East Asia: EAPC -2.02), whereas progress was limited in low-SDI areas such as Southern and Eastern Sub-Saharan Africa. A strong negative correlation between SDI and incidence trends (ρ=-0.491) underscored the influence of socioeconomic development on disease reduction.
[CONCLUSIONS] This study reveals marked regional and demographic disparities in stomach cancer trends among aging populations. Socioeconomic development plays a central role in reducing incidence. To reduce global health inequities, efforts should prioritize equitable access to screening and treatment, culturally tailored prevention programs, and investment in healthcare infrastructure in low-SDI regions.
[METHODS] Data on stomach cancer incidence were extracted from the GBD 2021 database. We analyzed incidence rates for individuals aged 50-74 years, stratified by age, sex, and geographic region. Trends from 1990 to 2021 were evaluated using the Estimated Annual Percentage Change (EAPC) based on log-linear regression models. Pearson correlation was used to examine associations between incidence trends and the Socio-Demographic Index (SDI). Data standardization was based on the GBD world standard population.
[RESULTS] From 1990 to 2021, the number of stomach cancer cases among individuals aged 50-74 years increased by 17.32%, while the incidence rates declined from 80.67 to 44.18 per 100,000 (EAPC: -2.15). Males consistently exhibited higher incidence rates than females. The decline was less pronounced in older age groups, particularly those aged 65-74 years, where the number of cases continued to rise, reflecting population aging and cumulative risk exposure. High-SDI regions experienced the largest reductions (e.g., East Asia: EAPC -2.02), whereas progress was limited in low-SDI areas such as Southern and Eastern Sub-Saharan Africa. A strong negative correlation between SDI and incidence trends (ρ=-0.491) underscored the influence of socioeconomic development on disease reduction.
[CONCLUSIONS] This study reveals marked regional and demographic disparities in stomach cancer trends among aging populations. Socioeconomic development plays a central role in reducing incidence. To reduce global health inequities, efforts should prioritize equitable access to screening and treatment, culturally tailored prevention programs, and investment in healthcare infrastructure in low-SDI regions.
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