LncRNA HOXC-AS1 Promotes Tumor Progression via miR-876-3p/NR3C1 in Hepatocellular Carcinoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: high HOXC-AS1 levels had lower disease-free survival and overall survival rates than cases with low HOXC-AS1 levels (p < 0
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
miR-876-3p could reverse the functions of HOXC-AS1 for HCC cells by targeting NR3C1. Upregulation of HOXC-AS1 promotes HCC progression through the miR-876-3p/NR3C1 axis.
Long non-coding RNAs (lncRNAs) are crucial regulators of hepatocellular carcinoma (HCC) development.
- p-value p < 0.001
APA
Wu D, Qu Y, et al. (2025). LncRNA HOXC-AS1 Promotes Tumor Progression via miR-876-3p/NR3C1 in Hepatocellular Carcinoma.. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 133(12), e70108. https://doi.org/10.1111/apm.70108
MLA
Wu D, et al.. "LncRNA HOXC-AS1 Promotes Tumor Progression via miR-876-3p/NR3C1 in Hepatocellular Carcinoma.." APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, vol. 133, no. 12, 2025, pp. e70108.
PMID
41365609 ↗
Abstract 한글 요약
Long non-coding RNAs (lncRNAs) are crucial regulators of hepatocellular carcinoma (HCC) development. The objective of the present investigation was to examine the lncRNA HOXC-AS1 levels in HCC and to explore the function of the HOXC-AS1/miR-876-3p/NR3C1 axis in HCC. Relative HOXC-AS1, miR-876-3p, and NR3C1 levels in tumor and paracancerous specimens were assessed by quantitative RT-PCR. sh-HOXC-AS1 was transfected into HCC cells to analyze its effects on HCC. The detection of cell growth, migration, and invasiveness was conducted by the CCK-8 assay along with Transwell analysis. Flow cytometry was employed to assess cell apoptosis. To evaluate the prognostic significance of HOXC-AS1, a Kaplan-Meier survival analysis was carried out. HOXC-AS1 was increased in HCC specimens in comparison with paracancerous tissues. Patients with high HOXC-AS1 levels had lower disease-free survival and overall survival rates than cases with low HOXC-AS1 levels (p < 0.001). Silencing HOXC-AS1 reduced the growth, migration, and invasiveness of HCC cells while promoting their apoptosis. As the direct target gene, miR-876-3p is negatively related to HOXC-AS1 levels. miR-876-3p could reverse the functions of HOXC-AS1 for HCC cells by targeting NR3C1. Upregulation of HOXC-AS1 promotes HCC progression through the miR-876-3p/NR3C1 axis.
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