Pyroptosis as a molecular bridge: linking gasdermin activation to enhanced anti-tumor immunity in immunotherapy.

Pyroptosis, a lysogenic pro-inflammatory kind of regulatory cell death mediated by the family of gasdermins, has gained substantial attention over the past few years. In a novel approach to tumor treatment, modification of the immune system is used to regulate and eradicate tumor cells and restore the body's inherent defenses against cancer. However, tumor immunotherapy faces several significant challenges, including decreased T cell responsiveness, limited immunogenicity, and the emergence of tumor cell drug resistance. Pyroptosis and tumor immunity may be related, emphasizing that pyroptosis may elicit strong anti-tumor immunity as a viable tumor therapy option. The molecular process of pyroptosis, its possible connection with various tumor immunotherapies, and potential pathways for triggering immunity by inducing pyroptosis are thoroughly reviewed in this article, and we hope to promote the application of pyroptosis in tumor immunotherapy.