Kremen2 Promotes Colorectal Cancer Progression by Activating the EGFR/JAK2/STAT3 Signaling Pathway.
1/5 보강
[BACKGROUND] Kremen2 is a key regulator of the Wnt/β-catenin signaling pathway, implicating in tumorigenesis.
APA
Xue X, Zhang S, Sun X (2026). Kremen2 Promotes Colorectal Cancer Progression by Activating the EGFR/JAK2/STAT3 Signaling Pathway.. Iranian journal of biotechnology, 24(1), e4234. https://doi.org/10.30498/ijb.2025.547463.4234
MLA
Xue X, et al.. "Kremen2 Promotes Colorectal Cancer Progression by Activating the EGFR/JAK2/STAT3 Signaling Pathway.." Iranian journal of biotechnology, vol. 24, no. 1, 2026, pp. e4234.
PMID
41472941 ↗
Abstract 한글 요약
[BACKGROUND] Kremen2 is a key regulator of the Wnt/β-catenin signaling pathway, implicating in tumorigenesis. While its role in colorectal cancer (CRC) remains largely unexplored.
[OBJECTIVES] This study aimed to investigate the biological function of Kremen2 in colorectal cancer and to elucidate the molecular mechanisms underlying its involvement in cancer cell proliferation and metastasis.
[MATERIALS AND METHODS] We examined Kremen2 expression in human colon cancer cell lines (SW480 and HCT116) and compared it to normal intestinal epithelial cells (NCM460). A Kremen2-knockdown cell model was established to assess the impact on cell proliferation and migration using standard in vitro assays. The associated signaling pathways were analyzed to determine mechanistic changes following Kremen2 suppression.
[RESULTS] Kremen2 expression was significantly elevated in colon cancer cell lines compared to normal controls. Knockdown of Kremen2 in HCT116 cells led to reduced cell viability and impaired migratory ability. Mechanistically, silencing Kremen2 resulted in downregulation of the EGFR/JAK2/STAT3 signaling pathway.
[CONCLUSIONS] Kremen2 promotes colorectal cancer cell proliferation and migration through activation of the EGFR/JAK2/STAT3 pathway. These findings identify Kremen2 as a potential therapeutic target in CRC.
[OBJECTIVES] This study aimed to investigate the biological function of Kremen2 in colorectal cancer and to elucidate the molecular mechanisms underlying its involvement in cancer cell proliferation and metastasis.
[MATERIALS AND METHODS] We examined Kremen2 expression in human colon cancer cell lines (SW480 and HCT116) and compared it to normal intestinal epithelial cells (NCM460). A Kremen2-knockdown cell model was established to assess the impact on cell proliferation and migration using standard in vitro assays. The associated signaling pathways were analyzed to determine mechanistic changes following Kremen2 suppression.
[RESULTS] Kremen2 expression was significantly elevated in colon cancer cell lines compared to normal controls. Knockdown of Kremen2 in HCT116 cells led to reduced cell viability and impaired migratory ability. Mechanistically, silencing Kremen2 resulted in downregulation of the EGFR/JAK2/STAT3 signaling pathway.
[CONCLUSIONS] Kremen2 promotes colorectal cancer cell proliferation and migration through activation of the EGFR/JAK2/STAT3 pathway. These findings identify Kremen2 as a potential therapeutic target in CRC.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- Copper/iron-based intelligent nanoparticles self-amplify apoptosis/ferroptosis/cuproptosis in colorectal cancer.
- Spatially resolved transcriptomics identifies tumor-stroma-immune networks and therapeutic targets in endocrine-resistant advanced breast cancer treated with Everolimus+Letrozole: insights from the MIRACLE trial.
- Comparative real-world survival of first-line atezolizumab, nivolumab, and pembrolizumab in older patients with metastatic non-small cell lung cancer.
- Impact of prophylactic bilateral salpingo-oophorectomy in patients with colorectal cancer with peritoneal metastasis during cytoreductive surgery: dual-center cohort analysis.
- Mechanisms underlying the promotion of papillary thyroid carcinoma occurrence and progression by Hashimoto's thyroiditis.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Opposing prognostic roles of tumor-associated and circulating MMP8 in colorectal cancer.
- Copper-enriched zinc peroxides induced cuproptosis through concurrent metabolic and oxidative dysregulation for boosting immunotherapy in colorectal cancer.
- Editorial: Altered metabolic traits in gastro-intestinal tract cancers, volume II.
- Macrophage deficiency discordantly regulated tumor growth and metastasis through increased thrombospondin-1 production.
- Time-Resolved Oxygen Dynamics Reveals Redox-Selective Apoptosis Induced by Cold Atmospheric Plasma in HT-29 Colorectal Cancer Cells.
- System-Wide Implementation of Colorectal Cancer Screening in a Value-Based Care Setting.