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Spatially resolved transcriptomics identifies tumor-stroma-immune networks and therapeutic targets in endocrine-resistant advanced breast cancer treated with Everolimus+Letrozole: insights from the MIRACLE trial.

2/5 보강

Cancer letters 📖 저널 OA 17.5% 2023~2026 2026 Vol.645() p. 218327 S100 Proteins and Annexins

TL;DR This study underscores the critical role of spatial gene expression analysis in elucidating the tumor microenvironment and its impact on prognosis in patients undergoing E+L treatment, thereby opening new avenues for targeted interventions.

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: endocrine therapy-resistant, hormone receptor-positive, HER2-non-amplified advanced breast cancer

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

Furthermore, the interaction between MMP11 and COL16A1 in stroma-rich regions suggests that cancer-associated fibroblasts may contribute to improved outcomes. Our study underscores the critical role of spatial gene expression analysis in elucidating the tumor microenvironment and its impact on prognosis in patients undergoing E + L treatment, thereby opening new avenues for targeted interventions.

OpenAlex 토픽 · S100 Proteins and Annexins Immune cells in cancer Ferroptosis and cancer prognosis

Xue X, Ji D, Xue L, Tan Y, Wang B, Wang J

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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