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6건-
A p53 peptide mucosal vaccine induces cellular and humoral immunity and anti-tumor effects in a murine colorectal cancer model.
Many patients with metastatic and recurrent colorectal cancer (CRC) have poor outcomes, due to resistance to current treatment approaches. Missense mutations in the TP53 gene are found in about 65% of CRCs, but no current treatment approach…
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Organ-metastatic landscape delineates overall and site-specific immune-related adverse events of PD-L1 blockade in advanced NSCLC.
It remains unknown whether metastases to different organs confer varying susceptibility to immune-related adverse events (irAEs) within a specific tumor type. We conducted a retrospective study included 708 advanced patients with non-small …
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Impacts of Globo H Ceramide on Tumor Microenvironment.
Although cancer immunotherapy has been flourishing, the number of targets for Food and Drug Administration (FDA)-approved cancer immunotherapeutics has remained small and mostly limited to proteins. The approval of dinutuximab, an anti-GD2 …
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Incidental Detection of Poorly Differentiated Neuroendocrine Carcinoma in Penile Urethra on 18 F-Fluciclovine PET/CT.
We report the case of an 88-year-old man with suspected biochemical recurrence of prostate cancer, in whom 18 F-fluciclovine PET/CT was performed in the context of rising prostate-specific antigen (PSA) levels. Incidental identification of …
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Exosome-derived Menin from cancer-associated fibroblasts promotes gastric cancer progression by activating the HSPA6/JNK/JunD pathway and inducing EMT.
[BACKGROUND] Our previous studies found that Menin was highly expressed in gastric cancer (GC) and could promote GC progression. Tumor microenvironment (TME), including cancer-associated fibroblasts (CAFs) and their exosomes plays pivotal r…
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Chaperonins in Hepatocellular Carcinoma: Unveiling Their Role in Tumor Proliferation and Immune Modulation Through Multiomics Analysis.
[BACKGROUND] Chaperonins are crucial regulators of tumor biology by controlling the stability and function of oncogenic and tumor-suppressor proteins, influencing various tumorigenic signaling pathways. Although chaperonins have been widely…