논문 목록
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When Binding Is Not Blockade: Interpreting IgG4 T Cells After PD-1 Therapy.
IgG4 positivity on circulating T cells after PD-1 therapy may indicate residual antibody binding rather than sustained functional PD-1 blockade. During sequential ramucirumab plus docetaxel plus G-CSF treatment, peripheral IgG4 T-cell dynam…
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Phase 1 Trial of BCL-2 Inhibitor Lisaftoclax (APG-2575) in Chinese Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Other Non-Hodgkin Lymphomas.
[BACKGROUND] Lisaftoclax is a novel BCL-2 inhibitor. This phase 1 trial (NCT03913949) evaluated the safety and preliminary efficacy of lisaftoclax in Chinese patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), small …
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Magnetic resonance-guided simultaneous multi-focal adaptive radiotherapy for prostate, pElvis & metastases (MRgSMART-PEM) in prostate cancer: a prospective phase II study.
[PURPOSE] To evaluate the safety, feasibility, and patient-reported outcomes of magnetic resonance-guided simultaneous multi-focal adaptive radiotherapy for the prostate, pelvis, and metastases (MRgSMART-PEM) in patients with high-risk, ver…
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Clinical outcomes and immune contexture in SMARCA4-deficient gastric cancer patients.
Exploiting vulnerabilities in switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes for cancer therapy is a promising therapeutic strategy. The SWI/SNF chromatin remodeling complex acts as a regulatory component of transcri…
- RE: Electroacupuncture for quality of life during adjuvant chemotherapy in gastric cancer: a randomized trial.
- Atox1 promotes CRC progression by protecting DNA damage through interacts with a novel copper-binding protein PARP1.
- Letter to the Editor "Development and validation of a novel nomogram model for predicting postoperative survival of T4N0M0 NSCLC: a population-based survival analysis.
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Prolonged survival with alectinib in a patient with advanced lung adenocarcinoma: a case report and literature review.
[BACKGROUND] Alectinib is a second-generation tyrosine kinase inhibitor (TKI) that selectively targets anaplastic lymphoma kinase () rearrangements and is recommended as first-line therapy for patients with advanced -positive non-small cell…
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Bidirectional Mendelian randomization identifies differential causal associations between inflammatory cytokines and lung cancer subtypes.
Mendelian randomization study on relationships between inflammatory factors and lung cancer risk. Bidirectional two-sample Mendelian randomization approach, utilizing Genome-Wide Association Studies data for two primary lung cancer subtypes…
- Letter to the Editor - Efficacy and safety of neoadjuvant treatment of trastuzumab and pyrotinib plus dalpiciclib in HR-negative/HER2-positive breast cancer an exploratory, open-label phase II study.
- Rethinking AI-based prediction of NAT response in breast cancer: toward mechanistic and subtype-aware modeling - Letter to the Editor.
- Clarifying the survival impact of immunotherapy in HR+/HER2- metastatic breast cancer: methodological caveats from a real-world perspective - Letter to the Editor.
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Ginsenosides in Modern Pharmaceutics: Mechanisms, Applications, Challenges, and Perspectives.
Ginsenosides are the primary bioactive constituents of , exhibiting multiple pharmacological activities, including neuroprotection, antitumor effects, anti-aging properties, and metabolic regulation. In this review, the molecular mechanisms…
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Efficacy and safety of neoadjuvant immunotherapy in locally advanced resectable esophageal squamous cell carcinoma: a network meta-analysis and real-world study.
[INTRODUCTION] This study aimed to explore the efficacy and safety of neoadjuvant immunotherapy combination regimens in locally advanced resectable esophageal squamous cell carcinoma (ESCC), and evaluate the pros and cons of different regim…
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G-Quadruplex-Modular CpG Nanoplatform Drives Multi-Pathway Immunity for Abscopal Chemoimmunotherapy.
Conventional cancer immunotherapy suffers from insufficient immune activation, immunosuppressive tumor microenvironment (TME), and rapid CpG adjuvant degradation. To address these challenges, we developed a G-quadruplex (G4)-modular CpG nan…
- Value of intratumoral and peritumoral radiomics based on DCE-MRI in predicting HER2-low and HER2-zero in breast cancer.
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Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer.
Triple-negative breast cancer (TNBC) urgently requires promising therapeutic targets. This study identifies sclerostin, an osteocyte-derived secretory protein traditionally linked to bone homeostasis, as an unexpected intracellular oncogeni…
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Enhancing prognostic precision: exploring the role of lung immune prognostic index in immunotherapy-treated soft tissue sarcoma patients-a retrospective study.
[BACKGROUND] Soft tissue sarcoma (STS), is a rare and heterogeneous malignant mesenchymal tumor that has seen limited therapeutic advances in the past five decades, resulting in limited therapeutic efficacy and a poor prognosis in cases wit…
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Clinical characteristics of the ALK fusion-positive bladder PMP and efficacy of lorlatinib: a two-case report and literature review.
Pseudosarcomatous myofibroblastic proliferation (PMP) is a rare anaplastic lymphoma kinase (ALK), ALK fusion-associated tumor-like lesion that requires differentiation from inflammatory myofibroblastic tumor (IMT). This article reports two …
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Primary Orbital Lymphoma Manifesting as Increased Intraocular Pressure: A Case Report.
BACKGROUND Lymphoma can involve any orbital soft tissue (excluding bone) and may mimic other orbital diseases, often leading to misdiagnosis. Early diagnosis improves both disease management and patient survival. This rare case provides ins…
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In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy.
Recent studies have highlighted the pivotal role of the cGAS-STING pathway in cancer immunotherapy. However, clinical trials with cGAS-STING pathway agonists have faced setbacks thanks to their short biological half-life, lack of tumor spec…
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Diagnostic performance of apparent diffusion coefficient values in differentiating benign from malignant lesions in prostate PI-RADS v2.1 category 1 "nodules in nodule".
[OBJECTIVES] To explore the associations between the apparent diffusion coefficient (ADC) values of prostate PI-RADS v2.1 category 1 "nodules in nodule" and their pathological characteristics. [METHODS] We retrospectively analyzed the pros…
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Smad4 loss identifies aggressive subtype with immunotherapy and anti-HER-2 treatment resistance in gastric cancer.
[BACKGROUND] SMAD4 mutation and homozygous deletion represent the most prevalent genomic events driving aggressive biological behavior in gastric cancer (GC). However, clinical outcome and therapeutic response in GC patients with Smad4-loss…
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Synthetic NKG2D receptor (SNR) armored CAR-T cells overcome antigen heterogeneity of solid tumor.
[BACKGROUND] CAR-T cell therapy has demonstrated remarkable success in hematologic malignancies; however, its effectiveness against solid tumors remains limited due to tumor antigen heterogeneity. NKG2DLs, including MICA/B and the ULBP fami…
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Identification the Tumor Mechanics-Related Biomarkers in Gastric Cancer Patients Based on Bioinformatics and Machine Learning.
[BACKGROUND] Gastric cancer (GC) remains a major cause of cancer related mortality worldwide. Tumor mechanics, reflecting the physical and mechanical properties that influence tumor cell behavior and the tumor microenvironment (TME), play i…
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Clinical case report on the efficacy and safety of savolitinib in elderly patients with non-small cell lung cancer harboring skipping mutations.
[BACKGROUND] Savolitinib is the first small-molecule inhibitor specifically targeting mesenchymal-epithelial transition () tyrosine kinase approved in China. It is indicated for adult patients with locally advanced or metastatic non-small c…
- Refining perioperative immunotherapy strategies in resectable NSCLC: surgical and functional perspectives.
- Reappraising preoperative ctDNA in EGFR-mutant NSCLC: from detection to responsible clinical integration.
- Reframing the ozone-lung cancer link: toward exposure equity in urban China.
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Bioactive components and delivery strategies of food-medicine homologous substances in lung cancer therapy: current advances and clinical translation.
Lung cancer remains the leading cause of cancer-related mortality worldwide, challenged by drug resistance, treatment toxicities, and limited efficacy. Recently, food-medicine homologous (FMH) substances have gained attention as adjunctive …