When Binding Is Not Blockade: Interpreting IgG4 T Cells After PD-1 Therapy.
IgG4 positivity on circulating T cells after PD-1 therapy may indicate residual antibody binding rather than sustained functional PD-1 blockade.
APA
Sun M, Zang D, Chen J (2026). When Binding Is Not Blockade: Interpreting IgG4 T Cells After PD-1 Therapy.. Cancer science. https://doi.org/10.1111/cas.70379
MLA
Sun M, et al.. "When Binding Is Not Blockade: Interpreting IgG4 T Cells After PD-1 Therapy.." Cancer science, 2026.
PMID
41954043
Abstract
IgG4 positivity on circulating T cells after PD-1 therapy may indicate residual antibody binding rather than sustained functional PD-1 blockade. During sequential ramucirumab plus docetaxel plus G-CSF treatment, peripheral IgG4 T-cell dynamics may also be influenced by redistribution and treatment-related confounders, limiting direct inference about effective intratumoral antitumor immunity.
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