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Evaluating the efficacy of botulinum toxin type a in alleviating neuropsychological symptoms in hemifacial spasm patients.
[OBJECTIVE] To evaluate the efficacy of botulinum toxin type A (BTX-A) in the treatment of neuropsychological symptoms in patients with hemifacial spasm (HFS). [METHODS] Sixty-three HFS patients with neuropsychological symptoms were random…
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Combining Historic and Modern Concepts: How the Delay Phenomenon Enhances Propeller Flap Success in Large Dorsolumbar Soft Tissue Reconstruction.
The authors present a novel 2-staged approach for complex dorsolumbar wound reconstruction in a multioperated spine patient with limited local flap options and contraindications for free flap reconstruction due to arteriosclerosis and cardi…
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Effects of botulinum toxin type a on nucleotide binding oligomerization domain-like receptor 3 inflammasome in trigeminal ganglion of a rat migraine model.
[BACKGROUND] Botulinum toxin type A (BTX-A) has been used in the prevention and treatment of chronic migraine, but the detailed mechanism was not clear completely. [OBJECTIVE] The effects of BTX-A on nucleotide-binding oligomerization doma…
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A Retrospective Case Series Study of Illegal Cosmetic Iatrogenic Botulism: Outbreak Analysis and Response Lessons.
[BACKGROUND] Botulism is a rare and possibly life-threatening neuroparalytic syndrome. Recent large-scale outbreaks of iatrogenic botulism, primarily linked to cosmetic injections, have garnered significant attention. [OBJECTIVES] This stu…
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Advances in etiology, pathophysiology, diagnosis, and management of lymphedema: a comprehensive review.
Lymphedema is a chronic disorder of impaired lymphatic transport that leads to fluid accumulation, fibrosis, and adipose expansion. It presents as primary disease, caused by genetic defects in lymphatic development, or as secondary disease …
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Radial forearm free flap reconstruction in a 3-month-old patient with undifferentiated pharyngeal sarcoma.
There is minimal information regarding free tissue transfers in very young infants, especially those less than a year old. It is often thought that that age remains a limit to free tissue transfers, with younger patients having smaller vess…
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Clinical efficacy of flap transfer coverage in the treatment of vesicovaginal fistula.
[INTRODUCTION AND HYPOTHESIS] Vesicovaginal fistula (VVF) brings severe psychological, physiological, and social stress to patients, which seriously affects the quality of their sexual life. Traditional transvaginal repair surgery can cause…
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Safety and Efficacy of Botulinum Toxin Type A in Children With Spastic Cerebral Palsy Aged <2 Years: A Systematic Review.
In this study, we reviewed the safety and efficacy of botulinum toxin type A (BoNT-A) injection with respect to motor development in children with spastic cerebral palsy aged …
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Neutralizing Antibody Formation with OnabotulinumtoxinA (BOTOX) Treatment from Global Registration Studies across Multiple Indications: A Meta-Analysis.
Though the formation of neutralizing antibodies (NAbs) during treatment with botulinum neurotoxin is rare, their presence may nonetheless affect the biological activity of botulinum toxin and negatively impact clinical response. The goal of…
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Breaking the technical barrier of microvascular anastomosis with high-speed videography: A prospective cohort study.
[BACKGROUND] Microsurgical anastomosis is technically difficult especially for less-experienced surgeons. Traditionally, surgeons in training could only accomplish these surgeries under intensive guiding and supervision from senior surgeons…
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Synthesis and activity evaluation of selenazole-coupled CPI-1 irreversible bifunctional inhibitors for botulinum toxin A light chain.
A series of novel conjugates of benzoselenazole or selenazole and CPI-1 were designed, synthesized, and evaluated for inhibitory activities against the botulinum neurotoxin A (BoNT/A) light chain (LC) and BoNT/A in vivo. The results show th…
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Assessing the Bone-Forming Potential of Pericytes.
Human pericytes are a perivascular cell population with mesenchymal stem cell properties, present in all vascularized tissues. Human pericytes have a distinct immunoprofile, which may be leveraged for purposes of cell purification. Adipose …
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Comparative Study of Micro-Bone Window and Conventional Bone Window Microsurgery for Hypertensive Intracerebral Hemorrhage.
[OBJECTIVE] To compare and analyze the efficacy and safety of traditional craniotomy and small bone window craniotomy in the treatment of hypertensive cerebral hemorrhage (HICH). [PATIENTS AND METHODS] Fifty-four patients with HICH treated…
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Clinical analysis of EBRT vs TLM in the treatment of early (T1-T2N0) glottic laryngeal cancer.
To analyze the clinical efficacy of external beam radiation therapy (EBRT) vs transoral laser microsurgery (TLM) in patients with early glottic laryngeal carcinoma (T1-T2N0) and the effect of treatment choice on vocal function. A retrospec…
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Propofol-based total intravenous anesthesia decreases the incidence of postoperative nausea and vomiting without affecting flap survival in free flap breast reconstruction.
[BACKGROUND] Postoperative nausea and vomiting (PONV) may cause undesirable effects after microsurgical breast reconstruction. Although total intravenous anesthesia (TIVA) with propofol has been demonstrated to be effective in reducing PONV…
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The efficacy and safety of botulinum toxin type A in treatment of trigeminal neuralgia and peripheral neuropathic pain: A meta-analysis of randomized controlled trials.
[BACKGROUND] Although recent studies have shown that botulinum toxin-A (BTX-A) has a good analgesic effect on trigeminal neuralgia (TN) and peripheral neuropathic pain (PNP), the quality of evidence is low due to limited data. This meta-ana…
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The Three-Dimensional Techniques in the Objective Measurement of Breast Aesthetics.
[UNLABELLED] Breast symmetry, size, and shape are key components of aesthetic outcomes of augmentation mammoplasty, reduction, and reconstruction. Many have claimed that the 3D scanning technique, which measures breast volumes directly and …
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[Mask lift and facial aesthetic sculpturing].
[OBJECTIVE] To improve the outcome of the face-lift with a craniofacial contouring procedure. [METHODS] Thirty-seven patients aged 29-53 years (31 in female, 6 in male) were treated through a bicoronal incision. The facial tissue was lifte…