논문 목록
9건-
SEPT9 as a therapeutic target for enhancing radiotherapy efficacy in esophageal squamous cell carcinoma.
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis, where radiotherapy is a key treatment modality. However, radioresistance significantly limits its efficacy, leading to treatment failure. Septi…
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Design, synthesis, and in vitro/in vivo biological evaluation of Artesunate-Ebselen derivatives: GPX4-targeted ferroptosis induction and synergistic antitumor immune activation in colorectal cancer.
Glutathione peroxidase 4 (GPX4), a key regulator of ferroptosis, has emerged as a compelling therapeutic target for colorectal cancer (CRC). Capitalizing on the therapeutic promise of this target, we rationally designed and synthesized 24 n…
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Analysis of cancer stem cell mechanism and immune profiling in breast cancer of unknown primary.
[UNLABELLED] Cancer of unknown primary (CUP) encompasses a highly heterogeneous group of cancers with limited therapeutic options and a dismal prognosis. To date, the pathogenesis and immune profiling of CUP have not been fully characterize…
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Protocatechualdehyde induced tumor suppressive autophagy through AMPK/ULK1 signaling pathway in gastric cancer.
[BACKGROUND] Gastric cancer (GC) is one of the primary causes of cancer-related fatalities, which requires novel treatment including traditional Chinese medicine (TCM) to prolong survival. Protocatechualdehyde (PCA), a monomer from Chinese …
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Single-cell RNA Sequencing Demonstrates the Heterogeneity of Different Molecular Subtypes in Gastric Cancer.
Gastric cancer is a disease with high molecular and phenotypic heterogeneity. We integrated 119,878 cells from different molecular subtypes of gastric cancer and conducted comprehensive analysis. We found that patients with different molecu…
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Risk factors for lymph node metastasis and survival: Toward better endoscopic selection in ulcerative versus nonulcerative early gastric cancer.
[BACKGROUND] Lymph node metastasis (LNM) is a major determinant of patient outcomes in early gastric cancer (EGC) patients. This study aimed to identify risk factors for LNM and compare outcomes between patients with ulcerative EGC (UEGC) a…
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The clinical significance of hyperthermic intraperitoneal chemotherapy combined with PD-1 inhibitor and systemic chemotherapy for advanced gastric cancer patients with peritoneal metastasis: a single-center retrospective study.
[BACKGROUND] Peritoneal metastasis (PM) in gastric cancer (GC) correlates with a poor prognosis. PD-1 inhibitor has significantly transformed the treatment landscape for GC, but data on the combination of HIPEC with PD-1 inhibitor and syste…
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A Novel Pancreatic Cancer Hypoxia Status Related Gene Signature for Prognosis and Therapeutic Responses.
Pancreatic cancer (PAC) is a highly fatal and aggressive type of cancer. Hypoxia is a common feature of PAC. The aim of this study was to develop a hypoxia status-related prognostic model for predicting the survival outcomes in PAC. The dat…
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Diagnostic performance of next-generation sequencing and genetic profiling in thyroid nodules from a single center in China.
[OBJECTIVE] The data regarding the mutation landscape in Chinese patients with thyroid cancer are limited. The diagnostic performance of thyroid nodules by fine-needle aspiration (FNA) cytology needs optimization, especially in indeterminat…