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In Vivo Degradation of Crosslinked Hyaluronic Acid Fillers by Exogenous Hyaluronidases.
[BACKGROUND] An advantage of hyaluronic acid (HA)-based fillers is reversibility. [OBJECTIVE] To evaluate the ability of 2 hyaluronidases to degrade 3 HA-based fillers using a novel in vivo model. [MATERIALS AND METHODS] Rats were injecte…
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Skin extracellular matrix stimulation following injection of a hyaluronic acid-based dermal filler in a rat model.
[BACKGROUND] Hyaluronic acid-based dermal fillers have gained rapid acceptance for treating facial wrinkles and deep tissue folds. Although their space-filling properties are well understood, this study evaluates the cellular and molecular …