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A Prospective, Open-Label Study to Evaluate the Impact of VYC-12L Injection on Skin Quality Attributes in Healthy Volunteers.
[PURPOSE] Age-related changes in skin structure and function can negatively impact skin quality. VYC-12L is a crosslinked hyaluronic acid filler for treating fine lines and improving hydration and elasticity. The goal of this study was to u…
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Improvements in Skin Quality Biological Markers in Skin Explants Using Hyaluronic Acid Filler VYC-12L.
[UNLABELLED] Hyaluronic acid (HA), both crosslinked and uncrosslinked, is used clinically to treat fine lines and provides additional improvements in skin quality attributes. The purpose of this study was to assess potential early differenc…
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Novel Recombinant Tropoelastin Implants Restore Skin Extracellular Matrix.
[BACKGROUND] Elastin is an essential component of the dermis, providing skin with elasticity and integrity. Elastin and other dermal components are gradually lost through aging, sun damage, and following injury, highlighting a need to repla…
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In Vivo Degradation of Crosslinked Hyaluronic Acid Fillers by Exogenous Hyaluronidases.
[BACKGROUND] An advantage of hyaluronic acid (HA)-based fillers is reversibility. [OBJECTIVE] To evaluate the ability of 2 hyaluronidases to degrade 3 HA-based fillers using a novel in vivo model. [MATERIALS AND METHODS] Rats were injecte…
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Skin extracellular matrix stimulation following injection of a hyaluronic acid-based dermal filler in a rat model.
[BACKGROUND] Hyaluronic acid-based dermal fillers have gained rapid acceptance for treating facial wrinkles and deep tissue folds. Although their space-filling properties are well understood, this study evaluates the cellular and molecular …