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Harsh parenting and rs11621961 at the locus: gene-environment interaction effects on hair cortisol in a Brazilian population-based longitudinal study.
Hair cortisol concentration (HCC) reflects long-term hypothalamic-pituitary-adrenal (HPA) axis activity and is a biomarker of chronic stress. Although HCC has been linked to mental health, less is known about how genetic susceptibility and …
FULLTEXT: sensor array -
Smart graphene-enhanced ceramic material refractive index sensor simulation design developed for highly sensitive breast Cancer detection optimized with machine learning.
Based on the surface plasmon resonance (SPR) technique, the proposed biosensor is investigated as an SPR-based sensing platform for detecting breast cancer cells, specifically MCF-7 and MDA-MB-231 cells. Developed biosensor features an octa…
FULLTEXT: sensor array -
A chemiluminescent imaging immunosensor based on copper-doped NiFe PBA nanozyme for detection of BTN3A2: A candidate biomarker in early stage of gastric cancer.
The early diagnosis of gastric cancer (GC) faces great challenges due to the lack of specific biomarkers. Therefore, it is crucial to discover effective markers and establish highly sensitive detection methods. This study validated the pote…
FULLTEXT: sensor array -
Ultrasensitive biosensing platform via self-catalytic-induced luminescence amplification and bifunctional biopeptides for immunoassay.
The output signal of the sensor is closely correlated with its detection sensitivity, while the selection of luminescent materials and the presence of interfering substances in the detection medium can both affect the output signal. In this…
FULLTEXT: sensor array -
Immunosensors for dual tumor biomarker detection based on ternary electrochemiluminescence using confined CeO nanozyme as Co-reactant enhancers for luminol-O system.
Sensitive and parallel individual detection of multiple tumor biomarkers is critical for early diagnosis and therapeutic monitoring of pancreatic cancer. Herein, a ternary electrochemiluminescence (ECL) system was developed by employing nan…
FULLTEXT: sensor array -
Rib quality assessment using quantitative ultrasound imaging of bone.
This feasibility study evaluated quantitative ultrasound imaging of bone (QUSIB) for non-ionizing assessment of rib quality in the context of breast cancer treatment. In silico, microcomputed tomography-based rib models simulated five-year …
FULLTEXT: sensor array -
SLAMF1 at the crossroads of immunity and disease: Biology, pathology, and therapeutic opportunities.
TL;DRThese findings establish SLAMF1 as a biomarker and promising therapeutic target, warranting further translational investigation, and highlight its role as both a pathogen sensor and viral entry receptor.
FULLTEXT: sensor array -
Attogram per milliliter detection of prostate cancer biomarker using polymer dots-based electrolyte-gated organic field-effect transistor.
TL;DRThe positive and promising results of this study indicate that the developed Pdot EGOFET immunosensor holds significant potential as a highly effective platform for cancer diagnosis and therapeutic monitoring.
FULLTEXT: sensor array -
Electrochemical sensor based on MWCNTs/ZnONPs for detection of prostate specific antigen.
An electrochemical immunosensor based on multiwalled carbon nanotube/zinc oxide nanoparticle (MWCNTs/ZnONPs) composites was fabricated for the sensitive and selective detection of prostate-specific antigen (PSA), an established biomarker fo…
FULLTEXT: sensor array -
Mechanisms and therapeutic strategies of BiP-HSPA9 axis-mediated endoplasmic reticulum-mitochondria crosstalk driven by bile acids in gastric intestinal metaplasia.
TL;DRIt is validated that quercetin stabilizes BiP conformation, suppresses the IRE1α-XBP1-HSPA9 signaling axis, and restores ER-mitochondrial Ca2+ homeostasis, thereby mitigating oxidative stress and alleviating DCA-induced …
FULLTEXT: sensor array -
An electrochemical biosensing platform based on α‑iron trioxide/ferriferrous oxide magnetic nanocomposites for early diagnosis of hepatocellular carcinoma.
TL;DRThe STIP1 biosensing platform was successfully implemented for analyzing clinical spiked serum samples, demonstrating recovery rates ranging from 102.2 % to 114.2 %.
FULLTEXT: sensor array -
Rational engineering of a large Stokes shift fluorogenic sensor for sensing Notum in living systems and inhibitor screening.
TL;DRAn enzyme-activatable fluorogenic sensor for dynamic monitoring and multidimensional imaging of human Notum (hNotum) in complex biological systems and has the potential to advance the understanding of hNotum's role in hu…
FULLTEXT: sensor array -
Flower-like ZIF-L@Au NTs composite integrated with enrichment-enhancement ability for SERS detection of lung cancer VOC biomarker.
[BACKGROUND] Volatile organic compounds (VOCs) in human exhaled breath serve as molecular fingerprints that reflect metabolic dysregulation and can indicate the onset and progression of diseases such as lung cancer. Surface-enhanced Raman s…
FULLTEXT: sensor array -
Intracellular oxygen monitoring and oxygen demand assessment using Ir(ppy)-encapsulated polymeric micelles.
Intracellular oxygen concentration is a pivotal indicator of cellular metabolic and functional states that may be influenced by pathologic conditions, including hypoxia in solid tumors and hyperglycemia. Currently, methods for quantifying c…
FULLTEXT: sensor array -
Pharmacological targeting of nuclear factor (erythroid-derived 2)-like 2 (NRF2): a potential strategy to improve the efficacy of oncological photodynamic therapy.
TL;DRThis review outlines the current understanding of the nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway, how it is activated, and how it confers cytoprotective effects and ensures cell survival.
FULLTEXT: sensor array -
The pivotal role of metabolism in shaping tumor-associated macrophages phenotype and function.
Tumor progression is critically shaped by the dynamic interplay between tumor cells and the tumor microenvironment (TME). The TME harbors a diverse array of immune cells, encompassing T cell, B cell, NK cell and macrophages. Among these, TA…
FULLTEXT: sensor array -
Ultrasound cavitation therapy: inducing tumor drug delivery and blood flow changes with clinical ultrasound tools.
TL;DRTheranostic approach using ultrasound cavitation with a clinical scanner and FDA-approved microbubbles to enhance vascular permeability and drug delivery in HCC demonstrates the feasibility of therapeutic cavitation with…
FULLTEXT: sensor array -
Pencil-drawn paper-based portable photoelectrochemical immunoassay of carbohydrate antigen 19-9 based on TiO hollow cube homogeneous junctions.
TL;DRThis study provides a highly sensitive and portable detection platform for CA19-9, laying a foundation for its point-of-care and home-based early screening.
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Non-invasive detection of gastric cancer biomarker 4-HBA via a ZIF/CDs-based fluorescent sensor.
TL;DRThe development of a novel fluorescent sensor based on ZIF-8 and CDs embedded in a molecularly imprinted polymer matrix for the selective and sensitive detection of 4-hydroxybenzoic acid, a potential gastric cancer bioma…
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Boiling Histotripsy as a Non-Invasive Non-Thermal Approach for Treatment of Human Colon Cancer Tumors: An Ex Vivo Proof-of-Concept.
TL;DRA novel high‐intensity‐focused ultrasound (HIFU)‐based boiling histotripsy (BH) method has the potential to provide an ultrasound (US)‐guided approach for non‐invasive mechanical fractionation of CRC metastases and enhan…
FULLTEXT: sensor array